Tags

Type your tag names separated by a space and hit enter

Migraine preventive drugs differentially affect cortical spreading depression in rat.
Neurobiol Dis 2011; 41(2):430-5ND

Abstract

Cortical spreading depression (CSD) is the most likely cause of the migraine aura. Drugs with distinct pharmacological properties are effective in the preventive treatment of migraine. To test the hypothesis that their common denominator might be suppression of CSD we studied in rats the effect of three drugs used in migraine prevention: lamotrigine which is selectively effective on the aura but not on the headache, valproate and riboflavin which have a non-selective effect. Rats received for 4 weeks daily intraperitoneal injections of one of the three drugs. For valproate and riboflavin we used saline as control, for lamotrigine its vehicle dimethyl sulfoxide. After treatment, cortical spreading depressions were elicited for 2h by occipital KCl application. We measured CSD frequency, its propagation between a posterior (parieto-occipital) and an anterior (frontal) electrode, and number of Fos-immunoreactive nuclei in frontal cortex. Lamotrigine suppressed CSDs by 37% and 60% at posterior and anterior electrodes. Valproate had no effect on posterior CSDs, but reduced anterior ones by 32% and slowed propagation velocity. Riboflavin had no significant effect at neither recording site. Frontal Fos expression was decreased after lamotrigine and valproate, but not after riboflavin. Serum levels of administered drugs were within the range of those usually effective in patients. Our study shows that preventive anti-migraine drugs have differential effects on CSD. Lamotrigine has a marked suppressive effect which correlates with its rather selective action on the migraine aura. Valproate and riboflavin have no effect on the triggering of CSD, although they are effective in migraine without aura. Taken together, these results are compatible with a causal role of CSD in migraine with aura, but not in migraine without aura.

Authors+Show Affiliations

Headache Research Unit, GIGA-Neurosciences and Department of Neurology, Liège University, CHU Sart Tilman B36, T4, +1, B-4000, Liège, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20977938

Citation

Bogdanov, Volodymyr Borysovych, et al. "Migraine Preventive Drugs Differentially Affect Cortical Spreading Depression in Rat." Neurobiology of Disease, vol. 41, no. 2, 2011, pp. 430-5.
Bogdanov VB, Multon S, Chauvel V, et al. Migraine preventive drugs differentially affect cortical spreading depression in rat. Neurobiol Dis. 2011;41(2):430-5.
Bogdanov, V. B., Multon, S., Chauvel, V., Bogdanova, O. V., Prodanov, D., Makarchuk, M. Y., & Schoenen, J. (2011). Migraine preventive drugs differentially affect cortical spreading depression in rat. Neurobiology of Disease, 41(2), pp. 430-5. doi:10.1016/j.nbd.2010.10.014.
Bogdanov VB, et al. Migraine Preventive Drugs Differentially Affect Cortical Spreading Depression in Rat. Neurobiol Dis. 2011;41(2):430-5. PubMed PMID: 20977938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Migraine preventive drugs differentially affect cortical spreading depression in rat. AU - Bogdanov,Volodymyr Borysovych, AU - Multon,Sylvie, AU - Chauvel,Virginie, AU - Bogdanova,Olena Viktorivna, AU - Prodanov,Dimiter, AU - Makarchuk,Mykola Yukhymovych, AU - Schoenen,Jean, Y1 - 2010/10/23/ PY - 2010/08/30/received PY - 2010/10/10/revised PY - 2010/10/15/accepted PY - 2010/10/28/entrez PY - 2010/10/28/pubmed PY - 2011/12/13/medline SP - 430 EP - 5 JF - Neurobiology of disease JO - Neurobiol. Dis. VL - 41 IS - 2 N2 - Cortical spreading depression (CSD) is the most likely cause of the migraine aura. Drugs with distinct pharmacological properties are effective in the preventive treatment of migraine. To test the hypothesis that their common denominator might be suppression of CSD we studied in rats the effect of three drugs used in migraine prevention: lamotrigine which is selectively effective on the aura but not on the headache, valproate and riboflavin which have a non-selective effect. Rats received for 4 weeks daily intraperitoneal injections of one of the three drugs. For valproate and riboflavin we used saline as control, for lamotrigine its vehicle dimethyl sulfoxide. After treatment, cortical spreading depressions were elicited for 2h by occipital KCl application. We measured CSD frequency, its propagation between a posterior (parieto-occipital) and an anterior (frontal) electrode, and number of Fos-immunoreactive nuclei in frontal cortex. Lamotrigine suppressed CSDs by 37% and 60% at posterior and anterior electrodes. Valproate had no effect on posterior CSDs, but reduced anterior ones by 32% and slowed propagation velocity. Riboflavin had no significant effect at neither recording site. Frontal Fos expression was decreased after lamotrigine and valproate, but not after riboflavin. Serum levels of administered drugs were within the range of those usually effective in patients. Our study shows that preventive anti-migraine drugs have differential effects on CSD. Lamotrigine has a marked suppressive effect which correlates with its rather selective action on the migraine aura. Valproate and riboflavin have no effect on the triggering of CSD, although they are effective in migraine without aura. Taken together, these results are compatible with a causal role of CSD in migraine with aura, but not in migraine without aura. SN - 1095-953X UR - https://www.unboundmedicine.com/medline/citation/20977938/Migraine_preventive_drugs_differentially_affect_cortical_spreading_depression_in_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(10)00348-7 DB - PRIME DP - Unbound Medicine ER -