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Nutritional markers, not markers of bone turnover, are related predictors of bone mineral density in chronic peritoneal dialysis patients.
Clin Nephrol 2010; 74(5):336-42CN

Abstract

BACKGROUND AND AIMS

this study evaluated the factors associated with bone mineral density (BMD) in chronic peritoneal dialysis (CPD) patients.

METHODS

in this cross-sectional study in 91 stable CPD patients, BMD was measured using dual-energy X-ray absorptiometry. Markers of bone turnover (iPTH, osteocalcin, bone alkaline phosphatase, serum C-telopeptide), 25-hydroxy (OH) vitamin D3 and nutritional markers (prealbumin, nPNA, BMI) were measured by standard techniques.

RESULTS

of the 91 patients, 48 were female and 22 (24%) had Type 2 diabetes. Mean age of the patients was 52.7, and patients had been on PD for about 44 months. For the lumbar spine (LS) and femoral neck (FN), the mean T-scores were -1.19 ± 1.53 and -1.24 ± 1.01, respectively, and the mean Z-scores were -0.78 ± 1.33 and -0.40 ± 0.92, respectively. Using the WHO-based criteria, osteopenia (-2.5 < T-score < -1.0) at the LS and FN was observed in 37 (41%) and 48 (53%) patients, respectively, and osteoporosis (T-score <= -2.5) at the LS and FN was observed in 15 (17%) and 6 (7%) patients, respectively. LS T-score was positively correlated with BMI (r = 0.40, p < 0.001) and albumin (r = 0.29, p = 0.005), and FN T-score was positively correlated with albumin (r = 0.40, p < 0.001), prealbumin (r = 0.38, p < 0.001), age (r = -0.32, p = 0.002) and BMI (r = 0.29, p < 0.006). Markers of bone turnover were not associated with BMD. In multiple linear regression models, independent predictors of FN T-score were age, BMI, albumin and prealbumin (r(2) = 0.259, F = 6.23, p < 0.001), whereas BMI was the only independent predictor of LS T-score (r(2) = 0.24, F = 6.63, p < 0.001).

CONCLUSION

nutritional markers, not markers of bone turnover, are correlated predictors of BMD in CPD patients.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of UIsan College of Medicine, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20979940

Citation

Jeong, J U., et al. "Nutritional Markers, Not Markers of Bone Turnover, Are Related Predictors of Bone Mineral Density in Chronic Peritoneal Dialysis Patients." Clinical Nephrology, vol. 74, no. 5, 2010, pp. 336-42.
Jeong JU, Lee HK, Kim YJ, et al. Nutritional markers, not markers of bone turnover, are related predictors of bone mineral density in chronic peritoneal dialysis patients. Clin Nephrol. 2010;74(5):336-42.
Jeong, J. U., Lee, H. K., Kim, Y. J., Kim, J. S., Kang, S. S., & Kim, S. B. (2010). Nutritional markers, not markers of bone turnover, are related predictors of bone mineral density in chronic peritoneal dialysis patients. Clinical Nephrology, 74(5), pp. 336-42.
Jeong JU, et al. Nutritional Markers, Not Markers of Bone Turnover, Are Related Predictors of Bone Mineral Density in Chronic Peritoneal Dialysis Patients. Clin Nephrol. 2010;74(5):336-42. PubMed PMID: 20979940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional markers, not markers of bone turnover, are related predictors of bone mineral density in chronic peritoneal dialysis patients. AU - Jeong,J U, AU - Lee,H K, AU - Kim,Y J, AU - Kim,J S, AU - Kang,S S, AU - Kim,S B, PY - 2010/10/29/entrez PY - 2010/10/29/pubmed PY - 2010/12/22/medline SP - 336 EP - 42 JF - Clinical nephrology JO - Clin. Nephrol. VL - 74 IS - 5 N2 - BACKGROUND AND AIMS: this study evaluated the factors associated with bone mineral density (BMD) in chronic peritoneal dialysis (CPD) patients. METHODS: in this cross-sectional study in 91 stable CPD patients, BMD was measured using dual-energy X-ray absorptiometry. Markers of bone turnover (iPTH, osteocalcin, bone alkaline phosphatase, serum C-telopeptide), 25-hydroxy (OH) vitamin D3 and nutritional markers (prealbumin, nPNA, BMI) were measured by standard techniques. RESULTS: of the 91 patients, 48 were female and 22 (24%) had Type 2 diabetes. Mean age of the patients was 52.7, and patients had been on PD for about 44 months. For the lumbar spine (LS) and femoral neck (FN), the mean T-scores were -1.19 ± 1.53 and -1.24 ± 1.01, respectively, and the mean Z-scores were -0.78 ± 1.33 and -0.40 ± 0.92, respectively. Using the WHO-based criteria, osteopenia (-2.5 < T-score < -1.0) at the LS and FN was observed in 37 (41%) and 48 (53%) patients, respectively, and osteoporosis (T-score <= -2.5) at the LS and FN was observed in 15 (17%) and 6 (7%) patients, respectively. LS T-score was positively correlated with BMI (r = 0.40, p < 0.001) and albumin (r = 0.29, p = 0.005), and FN T-score was positively correlated with albumin (r = 0.40, p < 0.001), prealbumin (r = 0.38, p < 0.001), age (r = -0.32, p = 0.002) and BMI (r = 0.29, p < 0.006). Markers of bone turnover were not associated with BMD. In multiple linear regression models, independent predictors of FN T-score were age, BMI, albumin and prealbumin (r(2) = 0.259, F = 6.23, p < 0.001), whereas BMI was the only independent predictor of LS T-score (r(2) = 0.24, F = 6.63, p < 0.001). CONCLUSION: nutritional markers, not markers of bone turnover, are correlated predictors of BMD in CPD patients. SN - 0301-0430 UR - https://www.unboundmedicine.com/medline/citation/20979940/Nutritional_markers_not_markers_of_bone_turnover_are_related_predictors_of_bone_mineral_density_in_chronic_peritoneal_dialysis_patients_ L2 - http://www.dustri.com/nc/journals-in-english.html?artId=8058 DB - PRIME DP - Unbound Medicine ER -