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[Acute pancreatitis caused by hypertriglyceridemia].
Orv Hetil. 2010 Nov 07; 151(45):1869-74.OH

Abstract

Hypertriglyceridemia is reported to cause 1-7% of the cases of acute pancreatitis.

AIM

The aim of the present study was to assess the clinical features and management of pancreatitis with hypertriglyceridemia in our tertiary center.

METHODS

Between 1 January 2007 and 31 December 2009, patients with a diagnosis of hypertriglyceridemia-induced acute pancreatitis were reviewed. Patients with pancreatitis and serum triglyceride levels greater than 11.3 mmol/l (≈1000 mg/dl) were included. Acute pancreatitis with other etiologies was excluded.

RESULTS

26 patients (2 women, 24 men; median age at presentation 42 years; range: 22-70) were diagnosed with hypertriglyceridemia‑induced acute pancreatitis; 3 patients had altogether 7 relapses. The total number of cases was 33, which accounted for 4.71% of the total number of acute pancreatitis cases in the examined period. There was a failure in diet in 30.3% and a history of regular alcohol abuse in 57.6% of the cases. A history of diabetes mellitus was present in 38.1%, and gallstones in 9.1% of the cases. Lactescent serum was described on admission in 27.3%. Mean triglyceride level was 47.24 mmol/l (≈4181 mg/dl; 12.4-103.8 mmol/l). Amylase level was elevated to three times the normal in 54.5%, and that of lipase to three times the normal in 58.8%. Necrotizing acute pancreatitis was diagnosed in 7 patients (26.9%), and pseudocyst in 8 patients (30.7%). Administration of insulin, heparin, plasmapheresis and fibrates lowered the triglyceride to 3.71 mmol/l (≈328 mg/dl).

CONCLUSION

The clinical course of acute pancreatitis with hypertriglyceridemia does not differ from acute pancreatitis of other causes. Interestingly, levels of serum pancreatic enzymes may be normal or only minimally elevated. Insulin, heparin, plasmapheresis and fibrates effectively reduce lipid levels and relieve symptoms. A low triglyceride level is necessary to prevent relapses.

Authors+Show Affiliations

Szegedi Tudományegyetem, Általános Orvostudományi Kar I. Belgyógyászati Klinika Szeged Pf. 469 6701.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

hun

PubMed ID

20980226

Citation

Baranyai, Tamás, et al. "[Acute Pancreatitis Caused By Hypertriglyceridemia]." Orvosi Hetilap, vol. 151, no. 45, 2010, pp. 1869-74.
Baranyai T, Terzin V, Vajda A, et al. [Acute pancreatitis caused by hypertriglyceridemia]. Orv Hetil. 2010;151(45):1869-74.
Baranyai, T., Terzin, V., Vajda, A., Wittmann, T., & Czakó, L. (2010). [Acute pancreatitis caused by hypertriglyceridemia]. Orvosi Hetilap, 151(45), 1869-74. https://doi.org/10.1556/OH.2010.28966
Baranyai T, et al. [Acute Pancreatitis Caused By Hypertriglyceridemia]. Orv Hetil. 2010 Nov 7;151(45):1869-74. PubMed PMID: 20980226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute pancreatitis caused by hypertriglyceridemia]. AU - Baranyai,Tamás, AU - Terzin,Viktória, AU - Vajda,Agota, AU - Wittmann,Tibor, AU - Czakó,László, PY - 2010/10/29/entrez PY - 2010/10/29/pubmed PY - 2011/1/7/medline SP - 1869 EP - 74 JF - Orvosi hetilap JO - Orv Hetil VL - 151 IS - 45 N2 - UNLABELLED: Hypertriglyceridemia is reported to cause 1-7% of the cases of acute pancreatitis. AIM: The aim of the present study was to assess the clinical features and management of pancreatitis with hypertriglyceridemia in our tertiary center. METHODS: Between 1 January 2007 and 31 December 2009, patients with a diagnosis of hypertriglyceridemia-induced acute pancreatitis were reviewed. Patients with pancreatitis and serum triglyceride levels greater than 11.3 mmol/l (≈1000 mg/dl) were included. Acute pancreatitis with other etiologies was excluded. RESULTS: 26 patients (2 women, 24 men; median age at presentation 42 years; range: 22-70) were diagnosed with hypertriglyceridemia‑induced acute pancreatitis; 3 patients had altogether 7 relapses. The total number of cases was 33, which accounted for 4.71% of the total number of acute pancreatitis cases in the examined period. There was a failure in diet in 30.3% and a history of regular alcohol abuse in 57.6% of the cases. A history of diabetes mellitus was present in 38.1%, and gallstones in 9.1% of the cases. Lactescent serum was described on admission in 27.3%. Mean triglyceride level was 47.24 mmol/l (≈4181 mg/dl; 12.4-103.8 mmol/l). Amylase level was elevated to three times the normal in 54.5%, and that of lipase to three times the normal in 58.8%. Necrotizing acute pancreatitis was diagnosed in 7 patients (26.9%), and pseudocyst in 8 patients (30.7%). Administration of insulin, heparin, plasmapheresis and fibrates lowered the triglyceride to 3.71 mmol/l (≈328 mg/dl). CONCLUSION: The clinical course of acute pancreatitis with hypertriglyceridemia does not differ from acute pancreatitis of other causes. Interestingly, levels of serum pancreatic enzymes may be normal or only minimally elevated. Insulin, heparin, plasmapheresis and fibrates effectively reduce lipid levels and relieve symptoms. A low triglyceride level is necessary to prevent relapses. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/20980226/[Acute_pancreatitis_caused_by_hypertriglyceridemia]_ L2 - http://www.akademiai.com/doi/full/10.1556/OH.2010.28966?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -