Tags

Type your tag names separated by a space and hit enter

Bowel movement and constipation frequencies and the risk of colorectal cancer among men in the Netherlands Cohort Study on Diet and Cancer.
Am J Epidemiol. 2010 Dec 15; 172(12):1404-14.AJ

Abstract

The authors investigated the associations between bowel movement and constipation frequencies and colorectal cancer (CRC) endpoints among men in the Netherlands Cohort Study on Diet and Cancer (n = 58,279) and explored whether dietary fiber intake may modify associations. After 13.3 years (1986-1999), 1,207 CRC cases and 1,753 subcohort members were available for case-cohort analyses. Multivariate analyses showed a significantly increased hazard ratio for CRC overall and rectal cancer in men who reported having a bowel movement 1-2 times per day (second-highest category) as compared with once a day (CRC: hazard ratio (HR) = 1.29, 95% confidence interval (CI): 1.09, 1.53 (P(trend) < 0.001); rectal cancer: HR = 1.50, 95% CI: 1.15, 1.95 (P(trend) = 0.001)). Hazard ratios for CRC overall and rectal cancer were significantly decreased and lowest in men who reported suffering from constipation sometimes or more often versus never (CRC: HR = 0.76, 95% CI: 0.58, 0.98 (P(trend) = 0.02); rectal cancer: HR = 0.57, 95% CI: 0.35, 0.90 (P(trend) = 0.01)). No trends in the associations with proximal or distal colon cancer risk were observed. Interactions with dietary fiber intake were not significant. In this study, frequent bowel movements were associated with an increased risk of rectal cancer in men, and constipation was associated with a decreased risk.

Authors+Show Affiliations

Department of Epidemiology, Faculty of Health, Medicine and Life Sciences, MaastrichtUniversity, P.O. Box 616, 6200 MD Maastricht, The Netherlands. colinda.simons@epid.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20980354

Citation

Simons, Colinda C J M., et al. "Bowel Movement and Constipation Frequencies and the Risk of Colorectal Cancer Among Men in the Netherlands Cohort Study On Diet and Cancer." American Journal of Epidemiology, vol. 172, no. 12, 2010, pp. 1404-14.
Simons CC, Schouten LJ, Weijenberg MP, et al. Bowel movement and constipation frequencies and the risk of colorectal cancer among men in the Netherlands Cohort Study on Diet and Cancer. Am J Epidemiol. 2010;172(12):1404-14.
Simons, C. C., Schouten, L. J., Weijenberg, M. P., Goldbohm, R. A., & van den Brandt, P. A. (2010). Bowel movement and constipation frequencies and the risk of colorectal cancer among men in the Netherlands Cohort Study on Diet and Cancer. American Journal of Epidemiology, 172(12), 1404-14. https://doi.org/10.1093/aje/kwq307
Simons CC, et al. Bowel Movement and Constipation Frequencies and the Risk of Colorectal Cancer Among Men in the Netherlands Cohort Study On Diet and Cancer. Am J Epidemiol. 2010 Dec 15;172(12):1404-14. PubMed PMID: 20980354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bowel movement and constipation frequencies and the risk of colorectal cancer among men in the Netherlands Cohort Study on Diet and Cancer. AU - Simons,Colinda C J M, AU - Schouten,Leo J, AU - Weijenberg,Matty P, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, Y1 - 2010/10/27/ PY - 2010/10/29/entrez PY - 2010/10/29/pubmed PY - 2011/1/11/medline SP - 1404 EP - 14 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 172 IS - 12 N2 - The authors investigated the associations between bowel movement and constipation frequencies and colorectal cancer (CRC) endpoints among men in the Netherlands Cohort Study on Diet and Cancer (n = 58,279) and explored whether dietary fiber intake may modify associations. After 13.3 years (1986-1999), 1,207 CRC cases and 1,753 subcohort members were available for case-cohort analyses. Multivariate analyses showed a significantly increased hazard ratio for CRC overall and rectal cancer in men who reported having a bowel movement 1-2 times per day (second-highest category) as compared with once a day (CRC: hazard ratio (HR) = 1.29, 95% confidence interval (CI): 1.09, 1.53 (P(trend) < 0.001); rectal cancer: HR = 1.50, 95% CI: 1.15, 1.95 (P(trend) = 0.001)). Hazard ratios for CRC overall and rectal cancer were significantly decreased and lowest in men who reported suffering from constipation sometimes or more often versus never (CRC: HR = 0.76, 95% CI: 0.58, 0.98 (P(trend) = 0.02); rectal cancer: HR = 0.57, 95% CI: 0.35, 0.90 (P(trend) = 0.01)). No trends in the associations with proximal or distal colon cancer risk were observed. Interactions with dietary fiber intake were not significant. In this study, frequent bowel movements were associated with an increased risk of rectal cancer in men, and constipation was associated with a decreased risk. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20980354/Bowel_movement_and_constipation_frequencies_and_the_risk_of_colorectal_cancer_among_men_in_the_Netherlands_Cohort_Study_on_Diet_and_Cancer_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwq307 DB - PRIME DP - Unbound Medicine ER -