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Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells.
J Clin Pathol. 2010 Dec; 63(12):1059-65.JC

Abstract

AIMS

To report the clinicopathological characteristics of patients with ocular adnexal marginal zone B cell lymphoma (MZBL) with IgG4-positive plasma cells.

METHODS

114 biopsy samples of ocular adnexal MZBLs were analysed. MZBLs with IgG4-positive plasma cells were included when the IgG4:IgG ratio was >40% (IgG4-related group). The serum levels of each subclass of immunoglobulins and soluble interleukin-2 receptor in the IgG4-related group were compared with those in 61 consecutive patients having MZBL without IgG4-positive plasma cells (IgG4-unrelated group). They were also compared with those in 10 patients having ocular adnexal IgG4-related lymphoplasmacytic disorder (IgG4-related inflammatory group).

RESULTS

Ten (9%) of the patients were diagnosed with MZBL with IgG4-positive plasma cells. The IgG4-related group had a significantly greater degree of sclerosis and reactive follicles in the MZBLs (p=0.0004 and p=0.01, respectively). The serum levels of IgG, IgG1, IgG4, IgE and soluble interleukin 2 receptor in the IgG4-related group were significantly higher than those in the IgG4-unrelated group (p=0.003, p=0.009, p<0.0001, p<0.0001 and p=0.0007, respectively). The serum levels did not differ significantly from those of the IgG4-related inflammatory group. The IgG4-related group also had reactive IgG4-positive lymphoplasmacytic infiltrations in the recurrent lesion and in the stomach.

CONCLUSIONS

IgG4-positive plasma cells had infiltrated into ocular adnexal MZBLs in 9% of cases. It is suggested that ocular adnexal MZBLs with IgG4-positive plasma cells have unique histological and serological characteristics that overlap those of ocular adnexal IgG4-related lymphoplasmacytic infiltrative disorder and systemic conditions.

Authors+Show Affiliations

Department of Ophthalmology, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan. ganiky@nnh.hosp.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20980530

Citation

Kubota, Toshinobu, et al. "Ocular Adnexal Marginal Zone B Cell Lymphoma Infiltrated By IgG4-positive Plasma Cells." Journal of Clinical Pathology, vol. 63, no. 12, 2010, pp. 1059-65.
Kubota T, Moritani S, Yoshino T, et al. Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells. J Clin Pathol. 2010;63(12):1059-65.
Kubota, T., Moritani, S., Yoshino, T., Nagai, H., & Terasaki, H. (2010). Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells. Journal of Clinical Pathology, 63(12), 1059-65. https://doi.org/10.1136/jcp.2010.082156
Kubota T, et al. Ocular Adnexal Marginal Zone B Cell Lymphoma Infiltrated By IgG4-positive Plasma Cells. J Clin Pathol. 2010;63(12):1059-65. PubMed PMID: 20980530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells. AU - Kubota,Toshinobu, AU - Moritani,Suzuko, AU - Yoshino,Tadashi, AU - Nagai,Hirokazu, AU - Terasaki,Hiroko, Y1 - 2010/10/27/ PY - 2010/10/29/entrez PY - 2010/10/29/pubmed PY - 2011/4/7/medline SP - 1059 EP - 65 JF - Journal of clinical pathology JO - J. Clin. Pathol. VL - 63 IS - 12 N2 - AIMS: To report the clinicopathological characteristics of patients with ocular adnexal marginal zone B cell lymphoma (MZBL) with IgG4-positive plasma cells. METHODS: 114 biopsy samples of ocular adnexal MZBLs were analysed. MZBLs with IgG4-positive plasma cells were included when the IgG4:IgG ratio was >40% (IgG4-related group). The serum levels of each subclass of immunoglobulins and soluble interleukin-2 receptor in the IgG4-related group were compared with those in 61 consecutive patients having MZBL without IgG4-positive plasma cells (IgG4-unrelated group). They were also compared with those in 10 patients having ocular adnexal IgG4-related lymphoplasmacytic disorder (IgG4-related inflammatory group). RESULTS: Ten (9%) of the patients were diagnosed with MZBL with IgG4-positive plasma cells. The IgG4-related group had a significantly greater degree of sclerosis and reactive follicles in the MZBLs (p=0.0004 and p=0.01, respectively). The serum levels of IgG, IgG1, IgG4, IgE and soluble interleukin 2 receptor in the IgG4-related group were significantly higher than those in the IgG4-unrelated group (p=0.003, p=0.009, p<0.0001, p<0.0001 and p=0.0007, respectively). The serum levels did not differ significantly from those of the IgG4-related inflammatory group. The IgG4-related group also had reactive IgG4-positive lymphoplasmacytic infiltrations in the recurrent lesion and in the stomach. CONCLUSIONS: IgG4-positive plasma cells had infiltrated into ocular adnexal MZBLs in 9% of cases. It is suggested that ocular adnexal MZBLs with IgG4-positive plasma cells have unique histological and serological characteristics that overlap those of ocular adnexal IgG4-related lymphoplasmacytic infiltrative disorder and systemic conditions. SN - 1472-4146 UR - https://www.unboundmedicine.com/medline/citation/20980530/Ocular_adnexal_marginal_zone_B_cell_lymphoma_infiltrated_by_IgG4_positive_plasma_cells_ L2 - http://jcp.bmj.com/cgi/pmidlookup?view=long&amp;pmid=20980530 DB - PRIME DP - Unbound Medicine ER -