Tags

Type your tag names separated by a space and hit enter

Effects of dietary saturated and polyunsaturated fat on the metabolism of apolipoproteins A-I and B. Study of a patient with type IIb hyperlipoproteinaemia.
Clin Chim Acta. 1978 Aug 01; 87(3):395-404.CC

Abstract

The effects of dietary saturated and polyunsaturated fat on the metabolism of apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) were studied in a patient with type IIb hyperlipoproteinaemia. On the saturated fat diet, the rate of synthesis of very low density lipoprotein apoprotein B (VLDL-apoB) was approximately twice normal, accounting for the increased plasma VLDL pool in this subject. However, 54% of the synthesized VLDL-apoB was catabolized by a pathway independent of low density lipoproteins (LDL). The metabolic conversion rate of VLDL-apoB to LDL-apoB was normal in this subject and his expanded plasma LDL-apoB pool resulted, not from increased input of the apoprotein from VLDL, but from a decrease in its fractional clearance rate. On the polyunsaturated diet, there was a significant fall in the plasma cholesterol and triglyceride concentrations and a change in the fatty acid composition of all plasma lipoprotein fractions. These changes were accompanied by a decrease in the plasma concentrations of apoA-I and apoB which resulted from a reduction of apoprotein synthetic rate.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

209911

Citation

Shepherd, J, et al. "Effects of Dietary Saturated and Polyunsaturated Fat On the Metabolism of Apolipoproteins A-I and B. Study of a Patient With Type IIb Hyperlipoproteinaemia." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 87, no. 3, 1978, pp. 395-404.
Shepherd J, Packard CJ, Gotto AM, et al. Effects of dietary saturated and polyunsaturated fat on the metabolism of apolipoproteins A-I and B. Study of a patient with type IIb hyperlipoproteinaemia. Clin Chim Acta. 1978;87(3):395-404.
Shepherd, J., Packard, C. J., Gotto, A. M., & Taunton, O. D. (1978). Effects of dietary saturated and polyunsaturated fat on the metabolism of apolipoproteins A-I and B. Study of a patient with type IIb hyperlipoproteinaemia. Clinica Chimica Acta; International Journal of Clinical Chemistry, 87(3), 395-404.
Shepherd J, et al. Effects of Dietary Saturated and Polyunsaturated Fat On the Metabolism of Apolipoproteins A-I and B. Study of a Patient With Type IIb Hyperlipoproteinaemia. Clin Chim Acta. 1978 Aug 1;87(3):395-404. PubMed PMID: 209911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary saturated and polyunsaturated fat on the metabolism of apolipoproteins A-I and B. Study of a patient with type IIb hyperlipoproteinaemia. AU - Shepherd,J, AU - Packard,C J, AU - Gotto,A M,Jr AU - Taunton,O D, PY - 1978/8/1/pubmed PY - 2001/3/28/medline PY - 1978/8/1/entrez SP - 395 EP - 404 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 87 IS - 3 N2 - The effects of dietary saturated and polyunsaturated fat on the metabolism of apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) were studied in a patient with type IIb hyperlipoproteinaemia. On the saturated fat diet, the rate of synthesis of very low density lipoprotein apoprotein B (VLDL-apoB) was approximately twice normal, accounting for the increased plasma VLDL pool in this subject. However, 54% of the synthesized VLDL-apoB was catabolized by a pathway independent of low density lipoproteins (LDL). The metabolic conversion rate of VLDL-apoB to LDL-apoB was normal in this subject and his expanded plasma LDL-apoB pool resulted, not from increased input of the apoprotein from VLDL, but from a decrease in its fractional clearance rate. On the polyunsaturated diet, there was a significant fall in the plasma cholesterol and triglyceride concentrations and a change in the fatty acid composition of all plasma lipoprotein fractions. These changes were accompanied by a decrease in the plasma concentrations of apoA-I and apoB which resulted from a reduction of apoprotein synthetic rate. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/209911/Effects_of_dietary_saturated_and_polyunsaturated_fat_on_the_metabolism_of_apolipoproteins_A_I_and_B__Study_of_a_patient_with_type_IIb_hyperlipoproteinaemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0009-8981(78)90184-5 DB - PRIME DP - Unbound Medicine ER -