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Transcutaneous oxygen pressure and hemorheology in diabetes mellitus.
Int Angiol. 1990 Oct-Dec; 9(4):259-62.IA

Abstract

Diabetes is associated with altered blood viscosity and abnormal tissue oxygenation. Transcutaneous oxygen tension is measured in 119 diabetic and 20 normal subjects. Measurements of transcutaneous oxygen pressure (TcPO2) are made by Oxymonitor SM 361 at 45 degrees C at the dorsum of the foot. At the same time, the main microrheological parameters (plasma viscosity, albumin, fibrinogen, red cell aggregation times, disaggregation threshold and red cell aggregate structure index) are measured in diabetic patients with good and poor glycemic control, with and without angiopathy. All the diabetics have a significant reduction of TcPO2 and have rheological disturbances. TcPO2 values are related significantly with plasma viscosity and with several parameters of aggregation-disaggregation phenomenon. As for microrheological parameter abnormalities, it seems that tissue hypoxia precedes clinical signs of angiopathy and depends on the metabolic state as rheological abnormalities. TcPO2 values are the result of numerous parameters as rheological parameters. It seems that TcPO2 measurement is able to provide useful informations about microcirculation in diabetes mellitus without clinical signs of tissue hypoxia.

Authors+Show Affiliations

Unité de Recherches d'Hémorhéologie Clinique, Centre Hospitalier de Nevers, Pougues les Eaux, France.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2099959

Citation

Le Devehat, C, and T Khodabandehlou. "Transcutaneous Oxygen Pressure and Hemorheology in Diabetes Mellitus." International Angiology : a Journal of the International Union of Angiology, vol. 9, no. 4, 1990, pp. 259-62.
Le Devehat C, Khodabandehlou T. Transcutaneous oxygen pressure and hemorheology in diabetes mellitus. Int Angiol. 1990;9(4):259-62.
Le Devehat, C., & Khodabandehlou, T. (1990). Transcutaneous oxygen pressure and hemorheology in diabetes mellitus. International Angiology : a Journal of the International Union of Angiology, 9(4), 259-62.
Le Devehat C, Khodabandehlou T. Transcutaneous Oxygen Pressure and Hemorheology in Diabetes Mellitus. Int Angiol. 1990 Oct-Dec;9(4):259-62. PubMed PMID: 2099959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcutaneous oxygen pressure and hemorheology in diabetes mellitus. AU - Le Devehat,C, AU - Khodabandehlou,T, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez SP - 259 EP - 62 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 9 IS - 4 N2 - Diabetes is associated with altered blood viscosity and abnormal tissue oxygenation. Transcutaneous oxygen tension is measured in 119 diabetic and 20 normal subjects. Measurements of transcutaneous oxygen pressure (TcPO2) are made by Oxymonitor SM 361 at 45 degrees C at the dorsum of the foot. At the same time, the main microrheological parameters (plasma viscosity, albumin, fibrinogen, red cell aggregation times, disaggregation threshold and red cell aggregate structure index) are measured in diabetic patients with good and poor glycemic control, with and without angiopathy. All the diabetics have a significant reduction of TcPO2 and have rheological disturbances. TcPO2 values are related significantly with plasma viscosity and with several parameters of aggregation-disaggregation phenomenon. As for microrheological parameter abnormalities, it seems that tissue hypoxia precedes clinical signs of angiopathy and depends on the metabolic state as rheological abnormalities. TcPO2 values are the result of numerous parameters as rheological parameters. It seems that TcPO2 measurement is able to provide useful informations about microcirculation in diabetes mellitus without clinical signs of tissue hypoxia. SN - 0392-9590 UR - https://www.unboundmedicine.com/medline/citation/2099959/Transcutaneous_oxygen_pressure_and_hemorheology_in_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -