Tags

Type your tag names separated by a space and hit enter

A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients.
Braz J Med Biol Res. 1990; 23(8):647-54.BJ

Abstract

1. The effect of a 7-day low-protein diet on renal function was studied in 17 normotensive, normoalbuminuric, insulin-dependent diabetes mellitus (IDDM) patients. Glomerular filtration rate (GFR) and urinary albumin excretion (UAE) were measured after 7 days on an isocaloric low-protein diet (0.5 g protein/kg per day). 2. Compliance was confirmed by 24-h urinary urea levels. GFR was measured after a single injection of 51Cr-EDTA and UAE by radioimmunoassay. 3. GFR was reduced by 13.8% on the low-protein diet (139.9 +/- 27.7 vs 120.4 +/- 25.1 ml min-1 (1.73 m2)-1) (P less than 0.05). This effect was of the same magnitude as that obtained by others after long-term strict metabolic control. No changes were observed in UAE (5.6 +/- 6.4 vs 5.7 +/- 6.8 micrograms/min) during the study. The patients were classified as hyperfiltering (N = 9; GFR = 160.3 +/- 16.6 ml min-1 (1.73 m2)-1) or normofiltering (N = 8; GFR = 117.1 +/- 17.6 ml min-1 (1.73 m2)-1) on the basis of GFR, and no difference in the reduction of GFR was observed in either group. 4. The reduction in GFR is probably caused primarily by the reduction of protein intake since other factors that might influence the GFR such as glucose control and blood pressure did not change during the study.

Authors+Show Affiliations

Azevedo MJ
Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Brasil.
Padilha LM
No affiliation info available
Gross JL
No affiliation info available

MeSH

AdultAlbuminuriaBlood PressureDiabetes Mellitus, Type 1Dietary ProteinsFemaleGlomerular Filtration RateHumansMaleRadioimmunoassayTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2101087

Citation

Azevedo, M J., et al. "A Short-term Low-protein Diet Reduces Glomerular Filtration Rate in Insulin-dependent Diabetes Mellitus Patients." Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas, vol. 23, no. 8, 1990, pp. 647-54.
Azevedo MJ, Padilha LM, Gross JL. A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients. Braz J Med Biol Res. 1990;23(8):647-54.
Azevedo, M. J., Padilha, L. M., & Gross, J. L. (1990). A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas, 23(8), 647-54.
Azevedo MJ, Padilha LM, Gross JL. A Short-term Low-protein Diet Reduces Glomerular Filtration Rate in Insulin-dependent Diabetes Mellitus Patients. Braz J Med Biol Res. 1990;23(8):647-54. PubMed PMID: 2101087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients. AU - Azevedo,M J, AU - Padilha,L M, AU - Gross,J L, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 647 EP - 54 JF - Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas JO - Braz J Med Biol Res VL - 23 IS - 8 N2 - 1. The effect of a 7-day low-protein diet on renal function was studied in 17 normotensive, normoalbuminuric, insulin-dependent diabetes mellitus (IDDM) patients. Glomerular filtration rate (GFR) and urinary albumin excretion (UAE) were measured after 7 days on an isocaloric low-protein diet (0.5 g protein/kg per day). 2. Compliance was confirmed by 24-h urinary urea levels. GFR was measured after a single injection of 51Cr-EDTA and UAE by radioimmunoassay. 3. GFR was reduced by 13.8% on the low-protein diet (139.9 +/- 27.7 vs 120.4 +/- 25.1 ml min-1 (1.73 m2)-1) (P less than 0.05). This effect was of the same magnitude as that obtained by others after long-term strict metabolic control. No changes were observed in UAE (5.6 +/- 6.4 vs 5.7 +/- 6.8 micrograms/min) during the study. The patients were classified as hyperfiltering (N = 9; GFR = 160.3 +/- 16.6 ml min-1 (1.73 m2)-1) or normofiltering (N = 8; GFR = 117.1 +/- 17.6 ml min-1 (1.73 m2)-1) on the basis of GFR, and no difference in the reduction of GFR was observed in either group. 4. The reduction in GFR is probably caused primarily by the reduction of protein intake since other factors that might influence the GFR such as glucose control and blood pressure did not change during the study. SN - 0100-879X UR - https://www.unboundmedicine.com/medline/citation/2101087/A_short_term_low_protein_diet_reduces_glomerular_filtration_rate_in_insulin_dependent_diabetes_mellitus_patients_ DB - PRIME DP - Unbound Medicine ER -