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Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts.
J Affect Disord. 2011 Apr; 130(1-2):220-5.JA

Abstract

BACKGROUND

Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking.

METHODS

Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson's χ² tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic symptoms during mood episodes.

RESULTS

Seropositivity for influenza A (p=0.004), B (p<0.0001) and coronaviruses (p<0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p=0.001) and history of psychotic symptoms (p=0.005).

LIMITATIONS

The design was cross-sectional. Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed.

CONCLUSIONS

The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.

Authors+Show Affiliations

Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21030090

Citation

Okusaga, Olaoluwa, et al. "Association of Seropositivity for Influenza and Coronaviruses With History of Mood Disorders and Suicide Attempts." Journal of Affective Disorders, vol. 130, no. 1-2, 2011, pp. 220-5.
Okusaga O, Yolken RH, Langenberg P, et al. Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts. J Affect Disord. 2011;130(1-2):220-5.
Okusaga, O., Yolken, R. H., Langenberg, P., Lapidus, M., Arling, T. A., Dickerson, F. B., Scrandis, D. A., Severance, E., Cabassa, J. A., Balis, T., & Postolache, T. T. (2011). Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts. Journal of Affective Disorders, 130(1-2), 220-5. https://doi.org/10.1016/j.jad.2010.09.029
Okusaga O, et al. Association of Seropositivity for Influenza and Coronaviruses With History of Mood Disorders and Suicide Attempts. J Affect Disord. 2011;130(1-2):220-5. PubMed PMID: 21030090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts. AU - Okusaga,Olaoluwa, AU - Yolken,Robert H, AU - Langenberg,Patricia, AU - Lapidus,Manana, AU - Arling,Timothy A, AU - Dickerson,Faith B, AU - Scrandis,Debra A, AU - Severance,Emily, AU - Cabassa,Johanna A, AU - Balis,Theodora, AU - Postolache,Teodor T, Y1 - 2010/10/27/ PY - 2010/03/23/received PY - 2010/09/28/accepted PY - 2010/10/30/entrez PY - 2010/10/30/pubmed PY - 2011/7/30/medline SP - 220 EP - 5 JF - Journal of affective disorders JO - J Affect Disord VL - 130 IS - 1-2 N2 - BACKGROUND: Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking. METHODS: Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson's χ² tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic symptoms during mood episodes. RESULTS: Seropositivity for influenza A (p=0.004), B (p<0.0001) and coronaviruses (p<0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p=0.001) and history of psychotic symptoms (p=0.005). LIMITATIONS: The design was cross-sectional. Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed. CONCLUSIONS: The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/21030090/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(10)00610-5 DB - PRIME DP - Unbound Medicine ER -