Tags

Type your tag names separated by a space and hit enter

Spinal subarachnoid space pressure measurements in an in vitro spinal stenosis model: implications on syringomyelia theories.
J Biomech Eng. 2010 Nov; 132(11):111007.JB

Abstract

Full explanation for the pathogenesis of syringomyelia (SM), a neuropathology characterized by the formation of a cystic cavity (syrinx) in the spinal cord (SC), has not yet been provided. It has been hypothesized that abnormal cerebrospinal fluid (CSF) pressure, caused by subarachnoid space (SAS) flow blockage (stenosis), is an underlying cause of syrinx formation and subsequent pain in the patient. However, paucity in detailed in vivo pressure data has made theoretical explanations for the syrinx difficult to reconcile. In order to understand the complex pressure environment, four simplified in vitro models were constructed to have anatomical similarities with post-traumatic SM and Chiari malformation related SM. Experimental geometry and properties were based on in vivo data and incorporated pertinent elements such as a realistic CSF flow waveform, spinal stenosis, syrinx, flexible SC, and flexible spinal column. The presence of a spinal stenosis in the SAS caused peak-to-peak cerebrospinal fluid CSF pressure fluctuations to increase rostral to the stenosis. Pressure with both stenosis and syrinx present was complex. Overall, the interaction of the syrinx and stenosis resulted in a diastolic valve mechanism and rostral tensioning of the SC. In all experiments, the blockage was shown to increase and dissociate SAS pressure, while the axial pressure distribution in the syrinx remained uniform. These results highlight the importance of the properties of the SC and spinal SAS, such as compliance and permeability, and provide data for comparison with computational models. Further research examining the influence of stenosis size and location, and the importance of tissue properties, is warranted.

Authors+Show Affiliations

Integrative Bioscience Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. brynandrew.martin@epfl.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21034148

Citation

Martin, Bryn A., et al. "Spinal Subarachnoid Space Pressure Measurements in an in Vitro Spinal Stenosis Model: Implications On Syringomyelia Theories." Journal of Biomechanical Engineering, vol. 132, no. 11, 2010, p. 111007.
Martin BA, Labuda R, Royston TJ, et al. Spinal subarachnoid space pressure measurements in an in vitro spinal stenosis model: implications on syringomyelia theories. J Biomech Eng. 2010;132(11):111007.
Martin, B. A., Labuda, R., Royston, T. J., Oshinski, J. N., Iskandar, B., & Loth, F. (2010). Spinal subarachnoid space pressure measurements in an in vitro spinal stenosis model: implications on syringomyelia theories. Journal of Biomechanical Engineering, 132(11), 111007. https://doi.org/10.1115/1.4000089
Martin BA, et al. Spinal Subarachnoid Space Pressure Measurements in an in Vitro Spinal Stenosis Model: Implications On Syringomyelia Theories. J Biomech Eng. 2010;132(11):111007. PubMed PMID: 21034148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spinal subarachnoid space pressure measurements in an in vitro spinal stenosis model: implications on syringomyelia theories. AU - Martin,Bryn A, AU - Labuda,Richard, AU - Royston,Thomas J, AU - Oshinski,John N, AU - Iskandar,Bermans, AU - Loth,Francis, PY - 2010/11/2/entrez PY - 2010/11/3/pubmed PY - 2011/2/22/medline SP - 111007 EP - 111007 JF - Journal of biomechanical engineering JO - J Biomech Eng VL - 132 IS - 11 N2 - Full explanation for the pathogenesis of syringomyelia (SM), a neuropathology characterized by the formation of a cystic cavity (syrinx) in the spinal cord (SC), has not yet been provided. It has been hypothesized that abnormal cerebrospinal fluid (CSF) pressure, caused by subarachnoid space (SAS) flow blockage (stenosis), is an underlying cause of syrinx formation and subsequent pain in the patient. However, paucity in detailed in vivo pressure data has made theoretical explanations for the syrinx difficult to reconcile. In order to understand the complex pressure environment, four simplified in vitro models were constructed to have anatomical similarities with post-traumatic SM and Chiari malformation related SM. Experimental geometry and properties were based on in vivo data and incorporated pertinent elements such as a realistic CSF flow waveform, spinal stenosis, syrinx, flexible SC, and flexible spinal column. The presence of a spinal stenosis in the SAS caused peak-to-peak cerebrospinal fluid CSF pressure fluctuations to increase rostral to the stenosis. Pressure with both stenosis and syrinx present was complex. Overall, the interaction of the syrinx and stenosis resulted in a diastolic valve mechanism and rostral tensioning of the SC. In all experiments, the blockage was shown to increase and dissociate SAS pressure, while the axial pressure distribution in the syrinx remained uniform. These results highlight the importance of the properties of the SC and spinal SAS, such as compliance and permeability, and provide data for comparison with computational models. Further research examining the influence of stenosis size and location, and the importance of tissue properties, is warranted. SN - 1528-8951 UR - https://www.unboundmedicine.com/medline/citation/21034148/Spinal_subarachnoid_space_pressure_measurements_in_an_in_vitro_spinal_stenosis_model:_implications_on_syringomyelia_theories_ L2 - https://asmedigitalcollection.asme.org/biomechanical/article-lookup/doi/10.1115/1.4000089 DB - PRIME DP - Unbound Medicine ER -