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Abnormal diurnal pattern of cortisol secretion in patients after aneurysmal subarachnoid hemorrhage.
Stress. 2011 Mar; 14(2):156-65.S

Abstract

Substantial evidence suggests that impairment of the hypothalamus?pituitary system can occur following an aneurysmal subarachnoid hemorrhage (aSAH). Given that the diurnal cortisol rhythm is primarily controlled by the hypothalamus?pituitary system, this study examined whether changes in diurnal cortisol rhythm occurred after aSAH. Cortisol concentrations were measured in the saliva samples collected from patients after aSAH and other types of cerebral hemorrhage (non-aSAH) in the post-awakening period and at night (21:00?h), and the cortisol awakening response (CAR) and diurnal cortisol decline were determined. The area under the cortisol curve from immediately after to 45?min after awakening (CARauc) in the aSAH patient group was comparable to that in the non-aSAH or healthy control groups. However, an obvious cortisol peak was not found after the awakening period, and the morning/nighttime cortisol ratio in the aSAH patient group was significantly lower than that in other examined groups due to higher nighttime cortisol concentrations. In aSAH patients, the CARauc and nighttime cortisol concentrations were negatively correlated with the Fisher CT grade. These results indicate that the diurnal cortisol rhythm is not regulated normally after aSAH, and cortisol secretory activity decreases as the volume of subarachnoid bleeding increases. Our findings will be helpful to understand altered hypothalamus?pituitary?adrenal axis function after aSAH.

Authors+Show Affiliations

Department of Neurosurgery, Anam Hospital, Korea University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21034298

Citation

Shin, Il Y., et al. "Abnormal Diurnal Pattern of Cortisol Secretion in Patients After Aneurysmal Subarachnoid Hemorrhage." Stress (Amsterdam, Netherlands), vol. 14, no. 2, 2011, pp. 156-65.
Shin IY, Joo HM, Chung YG, et al. Abnormal diurnal pattern of cortisol secretion in patients after aneurysmal subarachnoid hemorrhage. Stress. 2011;14(2):156-65.
Shin, I. Y., Joo, H. M., Chung, Y. G., Kim, M. S., Park, J. W., & Ahn, R. S. (2011). Abnormal diurnal pattern of cortisol secretion in patients after aneurysmal subarachnoid hemorrhage. Stress (Amsterdam, Netherlands), 14(2), 156-65. https://doi.org/10.3109/10253890.2010.522630
Shin IY, et al. Abnormal Diurnal Pattern of Cortisol Secretion in Patients After Aneurysmal Subarachnoid Hemorrhage. Stress. 2011;14(2):156-65. PubMed PMID: 21034298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal diurnal pattern of cortisol secretion in patients after aneurysmal subarachnoid hemorrhage. AU - Shin,Il Y, AU - Joo,Hye M, AU - Chung,Yong G, AU - Kim,Min S, AU - Park,Jung W, AU - Ahn,Ryun S, Y1 - 2010/10/31/ PY - 2010/11/2/entrez PY - 2010/11/3/pubmed PY - 2011/5/17/medline SP - 156 EP - 65 JF - Stress (Amsterdam, Netherlands) JO - Stress VL - 14 IS - 2 N2 - Substantial evidence suggests that impairment of the hypothalamus?pituitary system can occur following an aneurysmal subarachnoid hemorrhage (aSAH). Given that the diurnal cortisol rhythm is primarily controlled by the hypothalamus?pituitary system, this study examined whether changes in diurnal cortisol rhythm occurred after aSAH. Cortisol concentrations were measured in the saliva samples collected from patients after aSAH and other types of cerebral hemorrhage (non-aSAH) in the post-awakening period and at night (21:00?h), and the cortisol awakening response (CAR) and diurnal cortisol decline were determined. The area under the cortisol curve from immediately after to 45?min after awakening (CARauc) in the aSAH patient group was comparable to that in the non-aSAH or healthy control groups. However, an obvious cortisol peak was not found after the awakening period, and the morning/nighttime cortisol ratio in the aSAH patient group was significantly lower than that in other examined groups due to higher nighttime cortisol concentrations. In aSAH patients, the CARauc and nighttime cortisol concentrations were negatively correlated with the Fisher CT grade. These results indicate that the diurnal cortisol rhythm is not regulated normally after aSAH, and cortisol secretory activity decreases as the volume of subarachnoid bleeding increases. Our findings will be helpful to understand altered hypothalamus?pituitary?adrenal axis function after aSAH. SN - 1607-8888 UR - https://www.unboundmedicine.com/medline/citation/21034298/Abnormal_diurnal_pattern_of_cortisol_secretion_in_patients_after_aneurysmal_subarachnoid_hemorrhage_ L2 - https://www.tandfonline.com/doi/full/10.3109/10253890.2010.522630 DB - PRIME DP - Unbound Medicine ER -