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Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycle.
J Clin Psychiatry. 2011 Jan; 72(1):11-6.JC

Abstract

OBJECTIVE

This study evaluated the association between attention-deficit/hyperactivity disorder (ADHD) and psychometrically defined cognitive variables across the adult life span, using data from a large controlled study of adults with and without ADHD.

METHOD

Comparisons were made between 2 groups of adults: participants with DSM-IV-diagnosed ADHD who had never received pharmacotherapy for their ADHD (n = 116) and 146 control participants. Subjects received a battery assessing IQ, neuropsychological measures, and academic testing. We modeled cognitive measures as a function of age and group status using linear regression. The study was conducted at Massachusetts General Hospital, Boston, between 1998 and 2003.

RESULTS

ADHD and control subjects maintained similar, statistically significant differences in all psychometrically assessed measures of cognition within each decade that was represented (all P values < .01).

CONCLUSION

The negative impact of ADHD on multiple, nonoverlapping, psychometrically assessed measures of cognition remained constant across the life cycle, suggesting that the association between ADHD and cognition neither improves nor deteriorates across the life cycle.

Authors+Show Affiliations

Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit St, YAW 6A-6900, Boston, MA 02114, USA. jbiederman@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21034681

Citation

Biederman, Joseph, et al. "Cognitive Development in Adults With Attention-deficit/hyperactivity Disorder: a Controlled Study in Medication-naive Adults Across the Adult Life Cycle." The Journal of Clinical Psychiatry, vol. 72, no. 1, 2011, pp. 11-6.
Biederman J, Fried R, Petty CR, et al. Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycle. J Clin Psychiatry. 2011;72(1):11-6.
Biederman, J., Fried, R., Petty, C. R., Wozniak, J., Doyle, A. E., Henin, A., Corkum, L., Claudat, K., & Faraone, S. V. (2011). Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycle. The Journal of Clinical Psychiatry, 72(1), 11-6. https://doi.org/10.4088/JCP.09m05420pur
Biederman J, et al. Cognitive Development in Adults With Attention-deficit/hyperactivity Disorder: a Controlled Study in Medication-naive Adults Across the Adult Life Cycle. J Clin Psychiatry. 2011;72(1):11-6. PubMed PMID: 21034681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycle. AU - Biederman,Joseph, AU - Fried,Ronna, AU - Petty,Carter R, AU - Wozniak,Janet, AU - Doyle,Alysa E, AU - Henin,Aude, AU - Corkum,Lyndsey, AU - Claudat,Kim, AU - Faraone,Stephen V, Y1 - 2010/10/05/ PY - 2009/06/08/received PY - 2009/08/24/accepted PY - 2010/11/2/entrez PY - 2010/11/3/pubmed PY - 2011/2/26/medline SP - 11 EP - 6 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 72 IS - 1 N2 - OBJECTIVE: This study evaluated the association between attention-deficit/hyperactivity disorder (ADHD) and psychometrically defined cognitive variables across the adult life span, using data from a large controlled study of adults with and without ADHD. METHOD: Comparisons were made between 2 groups of adults: participants with DSM-IV-diagnosed ADHD who had never received pharmacotherapy for their ADHD (n = 116) and 146 control participants. Subjects received a battery assessing IQ, neuropsychological measures, and academic testing. We modeled cognitive measures as a function of age and group status using linear regression. The study was conducted at Massachusetts General Hospital, Boston, between 1998 and 2003. RESULTS: ADHD and control subjects maintained similar, statistically significant differences in all psychometrically assessed measures of cognition within each decade that was represented (all P values < .01). CONCLUSION: The negative impact of ADHD on multiple, nonoverlapping, psychometrically assessed measures of cognition remained constant across the life cycle, suggesting that the association between ADHD and cognition neither improves nor deteriorates across the life cycle. SN - 1555-2101 UR - https://www.unboundmedicine.com/medline/citation/21034681/Cognitive_development_in_adults_with_attention_deficit/hyperactivity_disorder:_a_controlled_study_in_medication_naive_adults_across_the_adult_life_cycle_ L2 - http://www.psychiatrist.com/jcp/article/pages/2011/v72n01/v72n0102.aspx DB - PRIME DP - Unbound Medicine ER -