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Metal-metal interactions of dietary cadmium, copper and zinc in rainbow trout, Oncorhynchus mykiss.
Ecotoxicol Environ Saf. 2011 May; 74(4):658-67.EE

Abstract

The influence of metal-metal interactions on uptake, accumulation, plasma transport and chronic toxicity of dietary Cu, Cd and Zn in rainbow trout (Oncorhynchus mykiss) was explored. Juvenile rainbow trout were fed diets supplemented with (μg/g) 500 Cu, 1000 Zn and 500 Cd singly and as a ternary mixture at 2.5% body weight daily ration for 28 days. Complex interactions among the metals dependent on the tissue/organ, metals ratios and duration of exposure were observed. While Zn did not accumulate, whole-body Cd and Cu concentrations increased following linear and saturation patterns, respectively. Early enhanced whole-body Cu accumulation in fish exposed to the metals mixture was correlated with reduced Cd concentration whereas late enhancement of Cd accumulation corresponded with elevated Cd concentration. This suggests early mutual antagonism and late cooperation between Cd and Cu probably due to interactions at temporally variable metal accumulation sites. At the level of uptake, Cd and Cu were either antagonistic or mutually increased the concentrations of each other depending on the duration of exposure and section of the gut. At the level of transport, enhanced Cd accumulation in plasma was closely correlated with reduced concentrations of both Zn and Cu indicating competitive binding to plasma proteins and/or antagonism at uptake sites. Compared to the Cu alone exposure, Cu concentrations were either lower (gills and carcasses) or higher (liver and kidney) in fish exposed to the metals mixture. On the other hand, Cd accumulation was enhanced in livers and carcasses of fish exposed to the mixture compared to those exposed to Cd alone, while Zn stimulated Cu accumulation in gills. Chronic toxicity was demonstrated by elevated malondialdehyde levels in livers and reduced concentrations of Zn and Cu in plasma. Overall, interactions of Cd, Cu and Zn are not always consistent with the isomorphous competitive binding theory.

Authors+Show Affiliations

Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE, Canada C1A 4P3. ckamunde@upei.caNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21035190

Citation

Kamunde, Collins, and Ruth MacPhail. "Metal-metal Interactions of Dietary Cadmium, Copper and Zinc in Rainbow Trout, Oncorhynchus Mykiss." Ecotoxicology and Environmental Safety, vol. 74, no. 4, 2011, pp. 658-67.
Kamunde C, MacPhail R. Metal-metal interactions of dietary cadmium, copper and zinc in rainbow trout, Oncorhynchus mykiss. Ecotoxicol Environ Saf. 2011;74(4):658-67.
Kamunde, C., & MacPhail, R. (2011). Metal-metal interactions of dietary cadmium, copper and zinc in rainbow trout, Oncorhynchus mykiss. Ecotoxicology and Environmental Safety, 74(4), 658-67. https://doi.org/10.1016/j.ecoenv.2010.10.016
Kamunde C, MacPhail R. Metal-metal Interactions of Dietary Cadmium, Copper and Zinc in Rainbow Trout, Oncorhynchus Mykiss. Ecotoxicol Environ Saf. 2011;74(4):658-67. PubMed PMID: 21035190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metal-metal interactions of dietary cadmium, copper and zinc in rainbow trout, Oncorhynchus mykiss. AU - Kamunde,Collins, AU - MacPhail,Ruth, Y1 - 2010/10/28/ PY - 2010/05/18/received PY - 2010/10/05/revised PY - 2010/10/06/accepted PY - 2010/11/2/entrez PY - 2010/11/3/pubmed PY - 2011/8/2/medline SP - 658 EP - 67 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 74 IS - 4 N2 - The influence of metal-metal interactions on uptake, accumulation, plasma transport and chronic toxicity of dietary Cu, Cd and Zn in rainbow trout (Oncorhynchus mykiss) was explored. Juvenile rainbow trout were fed diets supplemented with (μg/g) 500 Cu, 1000 Zn and 500 Cd singly and as a ternary mixture at 2.5% body weight daily ration for 28 days. Complex interactions among the metals dependent on the tissue/organ, metals ratios and duration of exposure were observed. While Zn did not accumulate, whole-body Cd and Cu concentrations increased following linear and saturation patterns, respectively. Early enhanced whole-body Cu accumulation in fish exposed to the metals mixture was correlated with reduced Cd concentration whereas late enhancement of Cd accumulation corresponded with elevated Cd concentration. This suggests early mutual antagonism and late cooperation between Cd and Cu probably due to interactions at temporally variable metal accumulation sites. At the level of uptake, Cd and Cu were either antagonistic or mutually increased the concentrations of each other depending on the duration of exposure and section of the gut. At the level of transport, enhanced Cd accumulation in plasma was closely correlated with reduced concentrations of both Zn and Cu indicating competitive binding to plasma proteins and/or antagonism at uptake sites. Compared to the Cu alone exposure, Cu concentrations were either lower (gills and carcasses) or higher (liver and kidney) in fish exposed to the metals mixture. On the other hand, Cd accumulation was enhanced in livers and carcasses of fish exposed to the mixture compared to those exposed to Cd alone, while Zn stimulated Cu accumulation in gills. Chronic toxicity was demonstrated by elevated malondialdehyde levels in livers and reduced concentrations of Zn and Cu in plasma. Overall, interactions of Cd, Cu and Zn are not always consistent with the isomorphous competitive binding theory. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/21035190/Metal_metal_interactions_of_dietary_cadmium_copper_and_zinc_in_rainbow_trout_Oncorhynchus_mykiss_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(10)00310-6 DB - PRIME DP - Unbound Medicine ER -