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Discrimination between patients with melancholic depression and healthy controls: comparison between 24-h cortisol profiles, the DST and the Dex/CRH test.
Psychoneuroendocrinology. 2011 Jun; 36(5):691-8.P

Abstract

Diurnal (24-h) cortisol profiles were compared to DST and Dex/CRH test outcomes with regard to their discriminative power in depressive disorder. With regard to several statistical measures (effect sizes, area under the curve) we found 24-h cortisol profiles to better discriminate between healthy controls and inpatients with the melancholic subtype of depression compared to the DST and Dex/CRH test. In search of a shortened time interval we found the 2-h time window 1000-1200 h of the cortisol profile to be the one with the highest sensitivity (83.3%) and specificity (87.9%). The specificity of the DST was 93.3% and somewhat higher than that of the cortisol profiles and the Dex/CRH test (87.9% and 78.8.%, respectively). However, the sensitivity of the DST was very low (30.8%), in fact similar to that of the Dex/CRH test (30.8%), but much lower than that of the 1000-1200 h interval (83.3%). The assessment of cortisol in plasma is an easy to perform, cost-saving method for the evaluation of the HPA system activity, which may have a series of clinical and scientific implications for the depressive disorder.

Authors+Show Affiliations

Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany. Georgios.Paslakis@zi-mannheim.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

21035272

Citation

Paslakis, Georgios, et al. "Discrimination Between Patients With Melancholic Depression and Healthy Controls: Comparison Between 24-h Cortisol Profiles, the DST and the Dex/CRH Test." Psychoneuroendocrinology, vol. 36, no. 5, 2011, pp. 691-8.
Paslakis G, Krumm B, Gilles M, et al. Discrimination between patients with melancholic depression and healthy controls: comparison between 24-h cortisol profiles, the DST and the Dex/CRH test. Psychoneuroendocrinology. 2011;36(5):691-8.
Paslakis, G., Krumm, B., Gilles, M., Schweiger, U., Heuser, I., Richter, I., & Deuschle, M. (2011). Discrimination between patients with melancholic depression and healthy controls: comparison between 24-h cortisol profiles, the DST and the Dex/CRH test. Psychoneuroendocrinology, 36(5), 691-8. https://doi.org/10.1016/j.psyneuen.2010.10.002
Paslakis G, et al. Discrimination Between Patients With Melancholic Depression and Healthy Controls: Comparison Between 24-h Cortisol Profiles, the DST and the Dex/CRH Test. Psychoneuroendocrinology. 2011;36(5):691-8. PubMed PMID: 21035272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discrimination between patients with melancholic depression and healthy controls: comparison between 24-h cortisol profiles, the DST and the Dex/CRH test. AU - Paslakis,Georgios, AU - Krumm,Bertram, AU - Gilles,Maria, AU - Schweiger,Ulrich, AU - Heuser,Isabella, AU - Richter,Inga, AU - Deuschle,Michael, Y1 - 2010/10/28/ PY - 2009/12/29/received PY - 2010/09/04/revised PY - 2010/10/03/accepted PY - 2010/11/2/entrez PY - 2010/11/3/pubmed PY - 2011/9/29/medline SP - 691 EP - 8 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 36 IS - 5 N2 - Diurnal (24-h) cortisol profiles were compared to DST and Dex/CRH test outcomes with regard to their discriminative power in depressive disorder. With regard to several statistical measures (effect sizes, area under the curve) we found 24-h cortisol profiles to better discriminate between healthy controls and inpatients with the melancholic subtype of depression compared to the DST and Dex/CRH test. In search of a shortened time interval we found the 2-h time window 1000-1200 h of the cortisol profile to be the one with the highest sensitivity (83.3%) and specificity (87.9%). The specificity of the DST was 93.3% and somewhat higher than that of the cortisol profiles and the Dex/CRH test (87.9% and 78.8.%, respectively). However, the sensitivity of the DST was very low (30.8%), in fact similar to that of the Dex/CRH test (30.8%), but much lower than that of the 1000-1200 h interval (83.3%). The assessment of cortisol in plasma is an easy to perform, cost-saving method for the evaluation of the HPA system activity, which may have a series of clinical and scientific implications for the depressive disorder. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/21035272/Discrimination_between_patients_with_melancholic_depression_and_healthy_controls:_comparison_between_24_h_cortisol_profiles_the_DST_and_the_Dex/CRH_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(10)00247-7 DB - PRIME DP - Unbound Medicine ER -