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Topography of the rabbit paranasal sinuses as a prerequisite to model human sinusitis.
Rhinology. 2010 Sep; 48(3):300-4.R

Abstract

BACKGROUND

Anatomical studies of the rabbit paranasal cavities are impelled by the increasing interest in the rabbit model to investigate human sinusitis. Although several such studies have already been performed, the topography of the rabbit dorsal conchal and maxillary sinuses is described ambiguously and the existence of the ethmoidal, frontal and sphenoidal sinuses is controversial.

METHODOLOGY

The paranasal cavities were investigated using corrosion casting, gross and histological cross-sectioning, and micro-CT scanning of rabbit noses followed by computerized three-dimensional reconstruction.

RESULTS

Micro-CT scanning was most useful to illustrate the dorsal conchal sinus, the large maxillary sinus consisting of a dorsal and a ventral recess, and the sphenoidal sinus. All these sinuses are paired and symmetrical. A large connection is present between the dorsal conchal sinus and the maxillary sinus resulting in one large conchomaxillary cavity. The sphenoidal sinus lies most caudal and is surrounded by the presphenoid bone. The openings from the nasal cavity into the conchomaxillary cavity and the sphenoidal sinus are very small.

CONCLUSIONS

The absence of frontal and ethmoidal sinuses in any of the rabbits examined is a major difference between the rabbit and human sinuses. The rabbit maxillary sinus seems most appropriate for experimental work.

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Authors+Show Affiliations

Casteleyn C
Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium. Christophe.Casteleyn@ugent.be
Cornillie P
No affiliation info available
Hermens A
No affiliation info available
Van Loo D
No affiliation info available
Van Hoorebeke L
No affiliation info available
van den Broeck W
No affiliation info available
Simoens P
No affiliation info available

MeSH

AnimalsDisease Models, AnimalFemaleMaleNasal CavityParanasal SinusesRabbitsSinusitisTomography, X-Ray Computed

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21038020

Citation

Casteleyn, Christophe, et al. "Topography of the Rabbit Paranasal Sinuses as a Prerequisite to Model Human Sinusitis." Rhinology, vol. 48, no. 3, 2010, pp. 300-4.
Casteleyn C, Cornillie P, Hermens A, et al. Topography of the rabbit paranasal sinuses as a prerequisite to model human sinusitis. Rhinology. 2010;48(3):300-4.
Casteleyn, C., Cornillie, P., Hermens, A., Van Loo, D., Van Hoorebeke, L., van den Broeck, W., & Simoens, P. (2010). Topography of the rabbit paranasal sinuses as a prerequisite to model human sinusitis. Rhinology, 48(3), 300-4. https://doi.org/10.4193/Rhin09.193
Casteleyn C, et al. Topography of the Rabbit Paranasal Sinuses as a Prerequisite to Model Human Sinusitis. Rhinology. 2010;48(3):300-4. PubMed PMID: 21038020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topography of the rabbit paranasal sinuses as a prerequisite to model human sinusitis. AU - Casteleyn,Christophe, AU - Cornillie,Pieter, AU - Hermens,Astrid, AU - Van Loo,Denis, AU - Van Hoorebeke,Luc, AU - van den Broeck,Wim, AU - Simoens,Paul, PY - 2010/11/2/entrez PY - 2010/11/3/pubmed PY - 2010/12/14/medline SP - 300 EP - 4 JF - Rhinology JO - Rhinology VL - 48 IS - 3 N2 - BACKGROUND: Anatomical studies of the rabbit paranasal cavities are impelled by the increasing interest in the rabbit model to investigate human sinusitis. Although several such studies have already been performed, the topography of the rabbit dorsal conchal and maxillary sinuses is described ambiguously and the existence of the ethmoidal, frontal and sphenoidal sinuses is controversial. METHODOLOGY: The paranasal cavities were investigated using corrosion casting, gross and histological cross-sectioning, and micro-CT scanning of rabbit noses followed by computerized three-dimensional reconstruction. RESULTS: Micro-CT scanning was most useful to illustrate the dorsal conchal sinus, the large maxillary sinus consisting of a dorsal and a ventral recess, and the sphenoidal sinus. All these sinuses are paired and symmetrical. A large connection is present between the dorsal conchal sinus and the maxillary sinus resulting in one large conchomaxillary cavity. The sphenoidal sinus lies most caudal and is surrounded by the presphenoid bone. The openings from the nasal cavity into the conchomaxillary cavity and the sphenoidal sinus are very small. CONCLUSIONS: The absence of frontal and ethmoidal sinuses in any of the rabbits examined is a major difference between the rabbit and human sinuses. The rabbit maxillary sinus seems most appropriate for experimental work. SN - 0300-0729 UR - https://www.unboundmedicine.com/medline/citation/21038020/Topography_of_the_rabbit_paranasal_sinuses_as_a_prerequisite_to_model_human_sinusitis_ L2 - https://www.rhinologyjournal.com/Abstract.php?id=881 DB - PRIME DP - Unbound Medicine ER -