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Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study.
Genes Brain Behav 2011; 10(2):149-57GB

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable developmental disorder characterized by a persistent impairing pattern of inattention and/or hyperactivity-impulsivity. Using families from a genetic isolate, the Paisa population from Colombia, and five independent datasets from four different populations (United States, Germany, Norway and Spain), a highly consistent association was recently reported between ADHD and the latrophilin 3 (LPHN3) gene, a brain-specific member of the LPHN subfamily of G-protein-coupled receptors that is expressed in ADHD-related regions, such as amygdala, caudate nucleus, cerebellum and cerebral cortex. To replicate the association between LPHN3 and ADHD in adults, we undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P = 0.0019; df = 1; odds ratio (OR) = 1.82 (1.25-2.70) and P = 5.1e-05; df = 1; OR = 2.25 (1.52-3.34), respectively]. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder, and point at this new neuronal pathway as a common susceptibility factor for ADHD throughout the lifespan.

Authors+Show Affiliations

Department of Psychiatry, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona, Catalonia, Spain. mribases@ir.vhebron.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21040458

Citation

Ribasés, M, et al. "Contribution of LPHN3 to the Genetic Susceptibility to ADHD in Adulthood: a Replication Study." Genes, Brain, and Behavior, vol. 10, no. 2, 2011, pp. 149-57.
Ribasés M, Ramos-Quiroga JA, Sánchez-Mora C, et al. Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study. Genes Brain Behav. 2011;10(2):149-57.
Ribasés, M., Ramos-Quiroga, J. A., Sánchez-Mora, C., Bosch, R., Richarte, V., Palomar, G., ... Casas, M. (2011). Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study. Genes, Brain, and Behavior, 10(2), pp. 149-57. doi:10.1111/j.1601-183X.2010.00649.x.
Ribasés M, et al. Contribution of LPHN3 to the Genetic Susceptibility to ADHD in Adulthood: a Replication Study. Genes Brain Behav. 2011;10(2):149-57. PubMed PMID: 21040458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study. AU - Ribasés,M, AU - Ramos-Quiroga,J A, AU - Sánchez-Mora,C, AU - Bosch,R, AU - Richarte,V, AU - Palomar,G, AU - Gastaminza,X, AU - Bielsa,A, AU - Arcos-Burgos,M, AU - Muenke,M, AU - Castellanos,F X, AU - Cormand,B, AU - Bayés,M, AU - Casas,M, Y1 - 2010/11/04/ PY - 2010/11/3/entrez PY - 2010/11/3/pubmed PY - 2011/6/16/medline SP - 149 EP - 57 JF - Genes, brain, and behavior JO - Genes Brain Behav. VL - 10 IS - 2 N2 - Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable developmental disorder characterized by a persistent impairing pattern of inattention and/or hyperactivity-impulsivity. Using families from a genetic isolate, the Paisa population from Colombia, and five independent datasets from four different populations (United States, Germany, Norway and Spain), a highly consistent association was recently reported between ADHD and the latrophilin 3 (LPHN3) gene, a brain-specific member of the LPHN subfamily of G-protein-coupled receptors that is expressed in ADHD-related regions, such as amygdala, caudate nucleus, cerebellum and cerebral cortex. To replicate the association between LPHN3 and ADHD in adults, we undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P = 0.0019; df = 1; odds ratio (OR) = 1.82 (1.25-2.70) and P = 5.1e-05; df = 1; OR = 2.25 (1.52-3.34), respectively]. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder, and point at this new neuronal pathway as a common susceptibility factor for ADHD throughout the lifespan. SN - 1601-183X UR - https://www.unboundmedicine.com/medline/citation/21040458/Contribution_of_LPHN3_to_the_genetic_susceptibility_to_ADHD_in_adulthood:_a_replication_study_ L2 - https://doi.org/10.1111/j.1601-183X.2010.00649.x DB - PRIME DP - Unbound Medicine ER -