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Effect of Ambrotose AO® on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults.
Nutr J. 2010 Nov 01; 9:49.NJ

Abstract

BACKGROUND

The purpose of this investigation was to determine the effects of a dietary supplement (Ambrotose AO®) on resting and exercise-induced blood antioxidant capacity and oxidative stress in exercise-trained and untrained men and women.

METHODS

25 individuals (7 trained and 5 untrained men; 7 trained and 6 untrained women) received Ambrotose AO® (4 capsules per day = 2 grams per day) or a placebo for 3 weeks in a random order, double blind cross-over design (with a 3 week washout period). Blood samples were collected at rest, and at 0 and 30 minutes following a graded exercise treadmill test (GXT) performed to exhaustion, both before and after each 3 week supplementation period. Samples were analyzed for Trolox Equivalent Antioxidant Capacity (TEAC), Oxygen Radical Absorbance Capacity (ORAC), malondialdehyde (MDA), hydrogen peroxide (H2O2), and nitrate/nitrite (NOx). Quality of life was assessed using the SF-12 form and exercise time to exhaustion was recorded. Resting blood samples were analyzed for complete blood count (CBC), metabolic panel, and lipid panel before and after each 3 week supplementation period. Dietary intake during the week before each exercise test was recorded.

RESULTS

No condition effects were noted for SF-12 data, for GXT time to exhaustion, or for any variable within the CBC, metabolic panel, or lipid panel (p > 0.05). Treatment with Ambrotose AO® resulted in an increase in resting levels of TEAC (p = 0.02) and ORAC (p < 0.0001). No significant change was noted in resting levels of MDA, H2O2, or NOx (p > 0.05). Exercise resulted in an acute increase in TEAC, MDA, and H2O2 (p < 0.05), all which were higher at 0 minutes post exercise compared to pre exercise (p < 0.05). No condition effects were noted for exercise related data (p > 0.05), with the exception of ORAC (p = 0.0005) which was greater at 30 minutes post exercise for Ambrotose AO® compared to placebo.

CONCLUSION

Ambrotose AO® at a daily dosage of 4 capsules per day increases resting blood antioxidant capacity and may enhance post exercise antioxidant capacity. However, no statistically detected difference is observed in resting or exercise-induced oxidative stress biomarkers, in quality of life, or in GXT time to exhaustion.

Authors+Show Affiliations

Cardiorespiratory/Metabolic Laboratory, The University of Memphis, Memphis, TN 38152, USA. rbloomer@memphis.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21040582

Citation

Bloomer, Richard J., et al. "Effect of Ambrotose AO® On Resting and Exercise-induced Antioxidant Capacity and Oxidative Stress in Healthy Adults." Nutrition Journal, vol. 9, 2010, p. 49.
Bloomer RJ, Canale RE, Blankenship MM, et al. Effect of Ambrotose AO® on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults. Nutr J. 2010;9:49.
Bloomer, R. J., Canale, R. E., Blankenship, M. M., & Fisher-Wellman, K. H. (2010). Effect of Ambrotose AO® on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults. Nutrition Journal, 9, 49. https://doi.org/10.1186/1475-2891-9-49
Bloomer RJ, et al. Effect of Ambrotose AO® On Resting and Exercise-induced Antioxidant Capacity and Oxidative Stress in Healthy Adults. Nutr J. 2010 Nov 1;9:49. PubMed PMID: 21040582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Ambrotose AO® on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults. AU - Bloomer,Richard J, AU - Canale,Robert E, AU - Blankenship,Megan M, AU - Fisher-Wellman,Kelsey H, Y1 - 2010/11/01/ PY - 2010/04/07/received PY - 2010/11/01/accepted PY - 2010/11/3/entrez PY - 2010/11/3/pubmed PY - 2011/1/14/medline SP - 49 EP - 49 JF - Nutrition journal JO - Nutr J VL - 9 N2 - BACKGROUND: The purpose of this investigation was to determine the effects of a dietary supplement (Ambrotose AO®) on resting and exercise-induced blood antioxidant capacity and oxidative stress in exercise-trained and untrained men and women. METHODS: 25 individuals (7 trained and 5 untrained men; 7 trained and 6 untrained women) received Ambrotose AO® (4 capsules per day = 2 grams per day) or a placebo for 3 weeks in a random order, double blind cross-over design (with a 3 week washout period). Blood samples were collected at rest, and at 0 and 30 minutes following a graded exercise treadmill test (GXT) performed to exhaustion, both before and after each 3 week supplementation period. Samples were analyzed for Trolox Equivalent Antioxidant Capacity (TEAC), Oxygen Radical Absorbance Capacity (ORAC), malondialdehyde (MDA), hydrogen peroxide (H2O2), and nitrate/nitrite (NOx). Quality of life was assessed using the SF-12 form and exercise time to exhaustion was recorded. Resting blood samples were analyzed for complete blood count (CBC), metabolic panel, and lipid panel before and after each 3 week supplementation period. Dietary intake during the week before each exercise test was recorded. RESULTS: No condition effects were noted for SF-12 data, for GXT time to exhaustion, or for any variable within the CBC, metabolic panel, or lipid panel (p > 0.05). Treatment with Ambrotose AO® resulted in an increase in resting levels of TEAC (p = 0.02) and ORAC (p < 0.0001). No significant change was noted in resting levels of MDA, H2O2, or NOx (p > 0.05). Exercise resulted in an acute increase in TEAC, MDA, and H2O2 (p < 0.05), all which were higher at 0 minutes post exercise compared to pre exercise (p < 0.05). No condition effects were noted for exercise related data (p > 0.05), with the exception of ORAC (p = 0.0005) which was greater at 30 minutes post exercise for Ambrotose AO® compared to placebo. CONCLUSION: Ambrotose AO® at a daily dosage of 4 capsules per day increases resting blood antioxidant capacity and may enhance post exercise antioxidant capacity. However, no statistically detected difference is observed in resting or exercise-induced oxidative stress biomarkers, in quality of life, or in GXT time to exhaustion. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/21040582/Effect_of_Ambrotose_AO®_on_resting_and_exercise_induced_antioxidant_capacity_and_oxidative_stress_in_healthy_adults_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-9-49 DB - PRIME DP - Unbound Medicine ER -