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Genetic diversities of 21 non-CODIS autosomal STRs of a Chinese Tibetan ethnic minority group in Lhasa.
Int J Legal Med. 2011 Jul; 125(4):581-5.IJ

Abstract

In the present study, we investigated 21 short tandem repeat (STR) loci (D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D19S433, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435, D5S2500), which are not included in the Combined DNA Index System and Amelogenin locus in 104 randomly selected healthy autochthonous individuals from the Tibetan ethnic minority group residing in the Lhasa region, Tibet Autonomous Region of China. Allelic frequencies, common forensic statistical parameters, and the Hardy-Weinberg equilibrium in this population were calculated with a modified PowerState V12.xls. A total of 143 alleles were found in the Tibetan group with corresponding allelic frequencies ranging from 0.005 to 0.582. The observed heterozygosity, the expected heterozygosity, the power of discrimination, the power of exclusion, and the polymorphic information content ranged from 0.615 to 0.817, 0.559 to 0.787, 0.727 to 0.926, 0.310 to 0.632, and 0.488 to 0.760, respectively. Chi-square tests of the observed genotype frequencies and expected genotype frequencies in the samples showed no departure from the Hardy-Weinberg equilibrium at all loci except for D5S2500. Our results demonstrate that these 21 STRs are highly polymorphic and suitable for anthropological research, population genetics, and forensic paternity testing and human individual identification in this region, and can enrich Chinese ethnical genetic informational resources.

Authors+Show Affiliations

The Key Laboratory of Environment and Gene Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China. zhubofeng@mail.xjtu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21042917

Citation

Zhu, Bo-feng, et al. "Genetic Diversities of 21 non-CODIS Autosomal STRs of a Chinese Tibetan Ethnic Minority Group in Lhasa." International Journal of Legal Medicine, vol. 125, no. 4, 2011, pp. 581-5.
Zhu BF, Shen CM, Wang HD, et al. Genetic diversities of 21 non-CODIS autosomal STRs of a Chinese Tibetan ethnic minority group in Lhasa. Int J Legal Med. 2011;125(4):581-5.
Zhu, B. F., Shen, C. M., Wang, H. D., Yang, G., Yan, J. W., Qin, H. X., Guo, J. X., Huang, J. F., Jing, H., & Liu, X. S. (2011). Genetic diversities of 21 non-CODIS autosomal STRs of a Chinese Tibetan ethnic minority group in Lhasa. International Journal of Legal Medicine, 125(4), 581-5. https://doi.org/10.1007/s00414-010-0519-4
Zhu BF, et al. Genetic Diversities of 21 non-CODIS Autosomal STRs of a Chinese Tibetan Ethnic Minority Group in Lhasa. Int J Legal Med. 2011;125(4):581-5. PubMed PMID: 21042917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic diversities of 21 non-CODIS autosomal STRs of a Chinese Tibetan ethnic minority group in Lhasa. AU - Zhu,Bo-feng, AU - Shen,Chun-mei, AU - Wang,Hong-dan, AU - Yang,Guang, AU - Yan,Jiang-wei, AU - Qin,Hai-xia, AU - Guo,Jian-xin, AU - Huang,Jing-feng, AU - Jing,Hang, AU - Liu,Xin-she, Y1 - 2010/11/03/ PY - 2010/08/09/received PY - 2010/09/30/accepted PY - 2010/11/3/entrez PY - 2010/11/3/pubmed PY - 2011/12/28/medline SP - 581 EP - 5 JF - International journal of legal medicine JO - Int J Legal Med VL - 125 IS - 4 N2 - In the present study, we investigated 21 short tandem repeat (STR) loci (D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D19S433, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435, D5S2500), which are not included in the Combined DNA Index System and Amelogenin locus in 104 randomly selected healthy autochthonous individuals from the Tibetan ethnic minority group residing in the Lhasa region, Tibet Autonomous Region of China. Allelic frequencies, common forensic statistical parameters, and the Hardy-Weinberg equilibrium in this population were calculated with a modified PowerState V12.xls. A total of 143 alleles were found in the Tibetan group with corresponding allelic frequencies ranging from 0.005 to 0.582. The observed heterozygosity, the expected heterozygosity, the power of discrimination, the power of exclusion, and the polymorphic information content ranged from 0.615 to 0.817, 0.559 to 0.787, 0.727 to 0.926, 0.310 to 0.632, and 0.488 to 0.760, respectively. Chi-square tests of the observed genotype frequencies and expected genotype frequencies in the samples showed no departure from the Hardy-Weinberg equilibrium at all loci except for D5S2500. Our results demonstrate that these 21 STRs are highly polymorphic and suitable for anthropological research, population genetics, and forensic paternity testing and human individual identification in this region, and can enrich Chinese ethnical genetic informational resources. SN - 1437-1596 UR - https://www.unboundmedicine.com/medline/citation/21042917/Genetic_diversities_of_21_non_CODIS_autosomal_STRs_of_a_Chinese_Tibetan_ethnic_minority_group_in_Lhasa_ L2 - https://dx.doi.org/10.1007/s00414-010-0519-4 DB - PRIME DP - Unbound Medicine ER -