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A review and meta-analysis of prospective studies of red and processed meat intake and prostate cancer.

Abstract

Over the past decade, several large epidemiologic investigations of meat intake and prostate cancer have been published. Therefore, a meta-analysis of prospective studies was conducted to estimate potential associations between red or processed meat intake and prostate cancer. Fifteen studies of red meat and 11 studies of processed meat were included in the analyses. High vs. low intake and dose-response analyses were conducted using random effects models to generate summary relative risk estimates (SRRE). No association between high vs. low red meat consumption (SRRE = 1.00, 95% CI: 0.96-1.05) or each 100 g increment of red meat (SRRE = 1.00, 95% CI: 0.95-1.05) and total prostate cancer was observed. Similarly, no association with red meat was observed for advanced prostate cancer (SRRE = 1.01, 95% CI: 0.94-1.09). A weakly elevated summary association between processed meat and total prostate cancer was found (SRRE = 1.05, 95% CI: 0.99-1.12), although heterogeneity was present, the association was attenuated in a sub-group analysis of studies that adjusted for multiple potential confounding factors, and publication bias likely affected the summary effect. In conclusion, the results of this meta-analysis are not supportive of an independent positive association between red or processed meat intake and prostate cancer.

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  • Authors+Show Affiliations

    ,

    Health Sciences Practice, Exponent Inc, 185 Hansen Court, Suite 100, Wood Dale, IL 60191, USA. dalexander@exponent.com

    , ,

    Source

    Nutrition journal 9: 2010 Nov 02 pg 50

    MeSH

    Cohort Studies
    Diet
    Dietary Fats
    Humans
    Male
    Meat
    Meat Products
    Prospective Studies
    Prostatic Neoplasms
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    21044319

    Citation

    Alexander, Dominik D., et al. "A Review and Meta-analysis of Prospective Studies of Red and Processed Meat Intake and Prostate Cancer." Nutrition Journal, vol. 9, 2010, p. 50.
    Alexander DD, Mink PJ, Cushing CA, et al. A review and meta-analysis of prospective studies of red and processed meat intake and prostate cancer. Nutr J. 2010;9:50.
    Alexander, D. D., Mink, P. J., Cushing, C. A., & Sceurman, B. (2010). A review and meta-analysis of prospective studies of red and processed meat intake and prostate cancer. Nutrition Journal, 9, p. 50. doi:10.1186/1475-2891-9-50.
    Alexander DD, et al. A Review and Meta-analysis of Prospective Studies of Red and Processed Meat Intake and Prostate Cancer. Nutr J. 2010 Nov 2;9:50. PubMed PMID: 21044319.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A review and meta-analysis of prospective studies of red and processed meat intake and prostate cancer. AU - Alexander,Dominik D, AU - Mink,Pamela J, AU - Cushing,Colleen A, AU - Sceurman,Bonnie, Y1 - 2010/11/02/ PY - 2009/11/20/received PY - 2010/11/02/accepted PY - 2010/11/4/entrez PY - 2010/11/4/pubmed PY - 2011/1/14/medline SP - 50 EP - 50 JF - Nutrition journal JO - Nutr J VL - 9 N2 - Over the past decade, several large epidemiologic investigations of meat intake and prostate cancer have been published. Therefore, a meta-analysis of prospective studies was conducted to estimate potential associations between red or processed meat intake and prostate cancer. Fifteen studies of red meat and 11 studies of processed meat were included in the analyses. High vs. low intake and dose-response analyses were conducted using random effects models to generate summary relative risk estimates (SRRE). No association between high vs. low red meat consumption (SRRE = 1.00, 95% CI: 0.96-1.05) or each 100 g increment of red meat (SRRE = 1.00, 95% CI: 0.95-1.05) and total prostate cancer was observed. Similarly, no association with red meat was observed for advanced prostate cancer (SRRE = 1.01, 95% CI: 0.94-1.09). A weakly elevated summary association between processed meat and total prostate cancer was found (SRRE = 1.05, 95% CI: 0.99-1.12), although heterogeneity was present, the association was attenuated in a sub-group analysis of studies that adjusted for multiple potential confounding factors, and publication bias likely affected the summary effect. In conclusion, the results of this meta-analysis are not supportive of an independent positive association between red or processed meat intake and prostate cancer. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/21044319/A_review_and_meta_analysis_of_prospective_studies_of_red_and_processed_meat_intake_and_prostate_cancer_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-9-50 DB - PRIME DP - Unbound Medicine ER -