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[Role of angiontensin receptors in remodeling perivascular nerves].
Yakugaku Zasshi. 2010 Nov; 130(11):1421-5.YZ

Abstract

The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fibers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar-Kyoto rats (WKY). The density of NPY-LI-containing nerve fibers was significantly greater in SHR than in WKY. SHR were treated for 7 weeks with angiotensin-converting enzyme inhibitor (0.005% temocapril), angiotensin II type-1 (AT1) receptor antagonist (0.025% losartan), or vasodilator (0.01% hydralazine) in their drinking water. Each drug treatment significantly lowered the systolic blood pressure measured using the tail-cuff method. Long-term treatment of SHR with temocapril and losartan significantly increased the density of CGRP-LI-containing nerve fibers in mesenteric arteries. Furthermore, to clarify the effect of the angiontensin II type-2 (AT2) receptor in the restoration of perivascular nerve innervation, we used the phenol-injured rat model, in which the perivascular nerves are markedly reduced by the topical application of phenol. Activation of AT2R significantly restored CGRP-LI innervation in phenol-injured rats. These results suggest that selective stimulation of AT2 receptors facilitates reinnervation of mesenteric perivascular CGRP-containing nerves.

Authors+Show Affiliations

Department of Life Science, Okayama University of Science, Okayama, Japan. hobara@dls.ous.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

jpn

PubMed ID

21048398

Citation

Hobara, Narumi, et al. "[Role of Angiontensin Receptors in Remodeling Perivascular Nerves]." Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, vol. 130, no. 11, 2010, pp. 1421-5.
Hobara N, Goda M, Hashikawa N, et al. [Role of angiontensin receptors in remodeling perivascular nerves]. Yakugaku Zasshi. 2010;130(11):1421-5.
Hobara, N., Goda, M., Hashikawa, N., Jin, X., Zamami, Y., Takatori, S., & Kawasaki, H. (2010). [Role of angiontensin receptors in remodeling perivascular nerves]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, 130(11), 1421-5.
Hobara N, et al. [Role of Angiontensin Receptors in Remodeling Perivascular Nerves]. Yakugaku Zasshi. 2010;130(11):1421-5. PubMed PMID: 21048398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role of angiontensin receptors in remodeling perivascular nerves]. AU - Hobara,Narumi, AU - Goda,Mitsuhiro, AU - Hashikawa,Naoya, AU - Jin,Xin, AU - Zamami,Yoshito, AU - Takatori,Shingo, AU - Kawasaki,Hiromu, PY - 2010/11/5/entrez PY - 2010/11/5/pubmed PY - 2011/2/4/medline SP - 1421 EP - 5 JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan JO - Yakugaku Zasshi VL - 130 IS - 11 N2 - The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fibers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar-Kyoto rats (WKY). The density of NPY-LI-containing nerve fibers was significantly greater in SHR than in WKY. SHR were treated for 7 weeks with angiotensin-converting enzyme inhibitor (0.005% temocapril), angiotensin II type-1 (AT1) receptor antagonist (0.025% losartan), or vasodilator (0.01% hydralazine) in their drinking water. Each drug treatment significantly lowered the systolic blood pressure measured using the tail-cuff method. Long-term treatment of SHR with temocapril and losartan significantly increased the density of CGRP-LI-containing nerve fibers in mesenteric arteries. Furthermore, to clarify the effect of the angiontensin II type-2 (AT2) receptor in the restoration of perivascular nerve innervation, we used the phenol-injured rat model, in which the perivascular nerves are markedly reduced by the topical application of phenol. Activation of AT2R significantly restored CGRP-LI innervation in phenol-injured rats. These results suggest that selective stimulation of AT2 receptors facilitates reinnervation of mesenteric perivascular CGRP-containing nerves. SN - 0031-6903 UR - https://www.unboundmedicine.com/medline/citation/21048398/[Role_of_angiontensin_receptors_in_remodeling_perivascular_nerves]_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/yakushi/130.1421?from=PubMed&lang=en DB - PRIME DP - Unbound Medicine ER -