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Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination.
Vaccine. 2010 Dec 06; 28(52):8258-67.V

Abstract

Understanding whether seasonal influenza vaccines can elicit antibody and T cell responses against the 2009 pandemic H1N1 strain is important. We compared T cell and antibody responses elicited by trivalent inactivated influenza vaccine (TIV) and live attenuated influenza vaccine (LAIV) in healthy adults. Both vaccines boosted pre-existing T cells to the seasonal and pandemic hemagglutinin (HA) but responses were significantly greater following immunization with LAIV. Antibody titers were significantly boosted only by TIV. The relationship between antibody and T cell responses and the effect of the magnitude of pre-existing immunity on vaccine-induced responses were also evaluated. Cross reactive T cell responses to the pandemic H1N1 HA existed among the cohort before the circulation of the virus to varying degrees and these responses were boosted by seasonal vaccination.

Authors+Show Affiliations

Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, OH, USA. Ramu.Subbramanian@cchmc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21050903

Citation

Subbramanian, Ramu A., et al. "Pandemic and Seasonal H1N1 Influenza Hemagglutinin-specific T Cell Responses Elicited By Seasonal Influenza Vaccination." Vaccine, vol. 28, no. 52, 2010, pp. 8258-67.
Subbramanian RA, Basha S, Shata MT, et al. Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination. Vaccine. 2010;28(52):8258-67.
Subbramanian, R. A., Basha, S., Shata, M. T., Brady, R. C., & Bernstein, D. I. (2010). Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination. Vaccine, 28(52), 8258-67. https://doi.org/10.1016/j.vaccine.2010.10.077
Subbramanian RA, et al. Pandemic and Seasonal H1N1 Influenza Hemagglutinin-specific T Cell Responses Elicited By Seasonal Influenza Vaccination. Vaccine. 2010 Dec 6;28(52):8258-67. PubMed PMID: 21050903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination. AU - Subbramanian,Ramu A, AU - Basha,Saleem, AU - Shata,Mohamed T, AU - Brady,Rebecca C, AU - Bernstein,David I, Y1 - 2010/11/02/ PY - 2010/07/24/received PY - 2010/10/23/revised PY - 2010/10/29/accepted PY - 2010/11/6/entrez PY - 2010/11/6/pubmed PY - 2011/3/16/medline SP - 8258 EP - 67 JF - Vaccine JO - Vaccine VL - 28 IS - 52 N2 - Understanding whether seasonal influenza vaccines can elicit antibody and T cell responses against the 2009 pandemic H1N1 strain is important. We compared T cell and antibody responses elicited by trivalent inactivated influenza vaccine (TIV) and live attenuated influenza vaccine (LAIV) in healthy adults. Both vaccines boosted pre-existing T cells to the seasonal and pandemic hemagglutinin (HA) but responses were significantly greater following immunization with LAIV. Antibody titers were significantly boosted only by TIV. The relationship between antibody and T cell responses and the effect of the magnitude of pre-existing immunity on vaccine-induced responses were also evaluated. Cross reactive T cell responses to the pandemic H1N1 HA existed among the cohort before the circulation of the virus to varying degrees and these responses were boosted by seasonal vaccination. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21050903/Pandemic_and_seasonal_H1N1_influenza_hemagglutinin_specific_T_cell_responses_elicited_by_seasonal_influenza_vaccination_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(10)01590-2 DB - PRIME DP - Unbound Medicine ER -