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The effect of levodopa dose and body weight on dyskinesia in a prevalent population of people with Parkinson's disease.
Parkinsonism Relat Disord. 2011 Jan; 17(1):27-9.PR

Abstract

AIMS AND OBJECTIVES

We aimed to investigate the effect of active dose and dose per kilogram (kg) of body weight of levodopa on the occurrence of dyskinesia within a prevalent population of people with PD.

METHODS

Of 106 prevalent cases, 75 (70.8%; 38 males, 37 females) agreed to assessment by a member of the research team. Demographic information, weight and height were recorded. Patients were assessed using a range of rating scales including the Unified Parkinson's Disease Rating Scale. Patients were asked specifically: 'Do you have, or have you ever had, dyskinesia?'.

RESULTS

Nine patients (12.0%) reported dyskinesia. Patient reported dyskinesia was significantly associated with greater years since diagnosis (r=0.309, p=0.007), higher levodopa equivalent dose (r=0.406, p<0.001) and levodopa equivalent dose per kg body weight (r=0.375, p<0.001). Using logistic regression, active levodopa dose, unadjusted for body weight, was an independent predictor of dyskinesia.

CONCLUSIONS

Adjusting levodopa dose for body weight did not increase its degree of correlation with patient reported dyskinesia.

Authors+Show Affiliations

Department of Medicine, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear NE29 8NH, UK. richard.walker@nhct.nhs.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21051272

Citation

Walker, Richard W., et al. "The Effect of Levodopa Dose and Body Weight On Dyskinesia in a Prevalent Population of People With Parkinson's Disease." Parkinsonism & Related Disorders, vol. 17, no. 1, 2011, pp. 27-9.
Walker RW, Howells AR, Gray WK. The effect of levodopa dose and body weight on dyskinesia in a prevalent population of people with Parkinson's disease. Parkinsonism Relat Disord. 2011;17(1):27-9.
Walker, R. W., Howells, A. R., & Gray, W. K. (2011). The effect of levodopa dose and body weight on dyskinesia in a prevalent population of people with Parkinson's disease. Parkinsonism & Related Disorders, 17(1), 27-9. https://doi.org/10.1016/j.parkreldis.2010.10.005
Walker RW, Howells AR, Gray WK. The Effect of Levodopa Dose and Body Weight On Dyskinesia in a Prevalent Population of People With Parkinson's Disease. Parkinsonism Relat Disord. 2011;17(1):27-9. PubMed PMID: 21051272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of levodopa dose and body weight on dyskinesia in a prevalent population of people with Parkinson's disease. AU - Walker,Richard W, AU - Howells,Anna R, AU - Gray,William K, Y1 - 2010/11/03/ PY - 2010/07/22/received PY - 2010/09/23/revised PY - 2010/10/08/accepted PY - 2010/11/6/entrez PY - 2010/11/6/pubmed PY - 2011/5/10/medline SP - 27 EP - 9 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 17 IS - 1 N2 - AIMS AND OBJECTIVES: We aimed to investigate the effect of active dose and dose per kilogram (kg) of body weight of levodopa on the occurrence of dyskinesia within a prevalent population of people with PD. METHODS: Of 106 prevalent cases, 75 (70.8%; 38 males, 37 females) agreed to assessment by a member of the research team. Demographic information, weight and height were recorded. Patients were assessed using a range of rating scales including the Unified Parkinson's Disease Rating Scale. Patients were asked specifically: 'Do you have, or have you ever had, dyskinesia?'. RESULTS: Nine patients (12.0%) reported dyskinesia. Patient reported dyskinesia was significantly associated with greater years since diagnosis (r=0.309, p=0.007), higher levodopa equivalent dose (r=0.406, p<0.001) and levodopa equivalent dose per kg body weight (r=0.375, p<0.001). Using logistic regression, active levodopa dose, unadjusted for body weight, was an independent predictor of dyskinesia. CONCLUSIONS: Adjusting levodopa dose for body weight did not increase its degree of correlation with patient reported dyskinesia. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/21051272/The_effect_of_levodopa_dose_and_body_weight_on_dyskinesia_in_a_prevalent_population_of_people_with_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(10)00252-X DB - PRIME DP - Unbound Medicine ER -