Tags

Type your tag names separated by a space and hit enter

Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials.
BMJ 2010; 341:c5702BMJ

Abstract

OBJECTIVE

To evaluate the effect of vitamin E supplementation on incident total, ischaemic, and haemorrhagic stroke.

DESIGN

Systematic review and meta-analysis of randomised, placebo controlled trials published until January 2010.

DATA SOURCES

Electronic databases (Medline, Embase, Cochrane Central Register of Controlled Trials) and reference lists of trial reports. Selection criteria Randomised, placebo controlled trials with ≥1 year of follow-up investigating the effect of vitamin E on stroke. Review methods and data extraction Two investigators independently assessed eligibility of identified trials. Disagreements were resolved by consensus. Two different investigators independently extracted data. Risk ratios (and 95% confidence intervals) were calculated for each trial based on the number of cases and non-cases randomised to vitamin E or placebo. Pooled effect estimates were then calculated.

RESULTS

Nine trials investigating the effect of vitamin E on incident stroke were included, totalling 118 765 participants (59 357 randomised to vitamin E and 59 408 to placebo). Among those, seven trials reported data for total stroke and five trials each for haemorrhagic and ischaemic stroke. Vitamin E had no effect on the risk for total stroke (pooled relative risk 0.98 (95% confidence interval 0.91 to 1.05), P=0.53). In contrast, the risk for haemorrhagic stroke was increased (pooled relative risk 1.22 (1.00 to 1.48), P=0.045), while the risk of ischaemic stroke was reduced (pooled relative risk 0.90 (0.82 to 0.99), P=0.02). There was little evidence for heterogeneity among studies. Meta-regression did not identify blinding strategy, vitamin E dose, or morbidity status of participants as sources of heterogeneity. In terms of absolute risk, this translates into one additional haemorrhagic stroke for every 1250 individuals taking vitamin E, in contrast to one ischaemic stroke prevented per 476 individuals taking vitamin E.

CONCLUSION

In this meta-analysis, vitamin E increased the risk for haemorrhagic stroke by 22% and reduced the risk of ischaemic stroke by 10%. This differential risk pattern is obscured when looking at total stroke. Given the relatively small risk reduction of ischaemic stroke and the generally more severe outcome of haemorrhagic stroke, indiscriminate widespread use of vitamin E should be cautioned against.

Authors+Show Affiliations

Division of Preventive Medicine, Department of Medicine; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204, USA. mschuerks@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

21051774

Citation

Schürks, Markus, et al. "Effects of Vitamin E On Stroke Subtypes: Meta-analysis of Randomised Controlled Trials." BMJ (Clinical Research Ed.), vol. 341, 2010, p. c5702.
Schürks M, Glynn RJ, Rist PM, et al. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ. 2010;341:c5702.
Schürks, M., Glynn, R. J., Rist, P. M., Tzourio, C., & Kurth, T. (2010). Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ (Clinical Research Ed.), 341, p. c5702. doi:10.1136/bmj.c5702.
Schürks M, et al. Effects of Vitamin E On Stroke Subtypes: Meta-analysis of Randomised Controlled Trials. BMJ. 2010 Nov 4;341:c5702. PubMed PMID: 21051774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. AU - Schürks,Markus, AU - Glynn,Robert J, AU - Rist,Pamela M, AU - Tzourio,Christophe, AU - Kurth,Tobias, Y1 - 2010/11/04/ PY - 2010/11/6/entrez PY - 2010/11/6/pubmed PY - 2010/11/17/medline SP - c5702 EP - c5702 JF - BMJ (Clinical research ed.) JO - BMJ VL - 341 N2 - OBJECTIVE: To evaluate the effect of vitamin E supplementation on incident total, ischaemic, and haemorrhagic stroke. DESIGN: Systematic review and meta-analysis of randomised, placebo controlled trials published until January 2010. DATA SOURCES: Electronic databases (Medline, Embase, Cochrane Central Register of Controlled Trials) and reference lists of trial reports. Selection criteria Randomised, placebo controlled trials with ≥1 year of follow-up investigating the effect of vitamin E on stroke. Review methods and data extraction Two investigators independently assessed eligibility of identified trials. Disagreements were resolved by consensus. Two different investigators independently extracted data. Risk ratios (and 95% confidence intervals) were calculated for each trial based on the number of cases and non-cases randomised to vitamin E or placebo. Pooled effect estimates were then calculated. RESULTS: Nine trials investigating the effect of vitamin E on incident stroke were included, totalling 118 765 participants (59 357 randomised to vitamin E and 59 408 to placebo). Among those, seven trials reported data for total stroke and five trials each for haemorrhagic and ischaemic stroke. Vitamin E had no effect on the risk for total stroke (pooled relative risk 0.98 (95% confidence interval 0.91 to 1.05), P=0.53). In contrast, the risk for haemorrhagic stroke was increased (pooled relative risk 1.22 (1.00 to 1.48), P=0.045), while the risk of ischaemic stroke was reduced (pooled relative risk 0.90 (0.82 to 0.99), P=0.02). There was little evidence for heterogeneity among studies. Meta-regression did not identify blinding strategy, vitamin E dose, or morbidity status of participants as sources of heterogeneity. In terms of absolute risk, this translates into one additional haemorrhagic stroke for every 1250 individuals taking vitamin E, in contrast to one ischaemic stroke prevented per 476 individuals taking vitamin E. CONCLUSION: In this meta-analysis, vitamin E increased the risk for haemorrhagic stroke by 22% and reduced the risk of ischaemic stroke by 10%. This differential risk pattern is obscured when looking at total stroke. Given the relatively small risk reduction of ischaemic stroke and the generally more severe outcome of haemorrhagic stroke, indiscriminate widespread use of vitamin E should be cautioned against. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/21051774/full_citation L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=21051774 DB - PRIME DP - Unbound Medicine ER -