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Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation.
Arch Pharm Res. 2010 Oct; 33(10):1509-20.AP

Abstract

Environmental or internal noxious stimuli excite the primary sensory nerves in our body. The sensory nerves relay these signals by electrical discharges to the brain, leading to pain perception. Six transient receptor potential (TRP) ion channels are expressed in the sensory nerve terminals and play a crucial role in sensing diverse noxious stimuli. Cation influx through activated TRP ion channels depolarizes the plasma membrane, resulting in neuronal excitation and pain. Natural and synthetic compounds have been found to act on these sensory TRP channels to alter the nociception. Evidence is growing that lipidergic substances are also cable of modifying TRP ion channel activity by direct binding. Here, we focus on endogenously generated lipids that modulate the sensory TRP activities. Unsaturated fatty acids or their metabolites via lipoxygenase, cyclooxygenase or epoxygenase are able to modulate (activate, inhibit or potentiate) the function of specific TRPs. Isoprene lipids, diacylglycerol, resolvin, and lysophospholipids also show distinct activities on sensory TRP channels. Outcomes caused by the interactions between sensory TRPs and lipid ligands are also discussed. The knowledge we collected here implicates that information on lipidergic ligands may contribute to our understanding of peripheral pain mechanism and provide an opportunity to design novel therapeutic strategies.

Authors+Show Affiliations

Korea University Graduate School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21052930

Citation

Bang, Sangsu, et al. "Endogenous Lipid-derived Ligands for Sensory TRP Ion Channels and Their Pain Modulation." Archives of Pharmacal Research, vol. 33, no. 10, 2010, pp. 1509-20.
Bang S, Yoo S, Oh U, et al. Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation. Arch Pharm Res. 2010;33(10):1509-20.
Bang, S., Yoo, S., Oh, U., & Hwang, S. W. (2010). Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation. Archives of Pharmacal Research, 33(10), 1509-20. https://doi.org/10.1007/s12272-010-1004-9
Bang S, et al. Endogenous Lipid-derived Ligands for Sensory TRP Ion Channels and Their Pain Modulation. Arch Pharm Res. 2010;33(10):1509-20. PubMed PMID: 21052930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation. AU - Bang,Sangsu, AU - Yoo,Sungjae, AU - Oh,Uhtaek, AU - Hwang,Sun Wook, Y1 - 2010/10/30/ PY - 2010/08/09/received PY - 2010/08/27/accepted PY - 2010/08/25/revised PY - 2010/11/6/entrez PY - 2010/11/6/pubmed PY - 2011/3/8/medline SP - 1509 EP - 20 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 33 IS - 10 N2 - Environmental or internal noxious stimuli excite the primary sensory nerves in our body. The sensory nerves relay these signals by electrical discharges to the brain, leading to pain perception. Six transient receptor potential (TRP) ion channels are expressed in the sensory nerve terminals and play a crucial role in sensing diverse noxious stimuli. Cation influx through activated TRP ion channels depolarizes the plasma membrane, resulting in neuronal excitation and pain. Natural and synthetic compounds have been found to act on these sensory TRP channels to alter the nociception. Evidence is growing that lipidergic substances are also cable of modifying TRP ion channel activity by direct binding. Here, we focus on endogenously generated lipids that modulate the sensory TRP activities. Unsaturated fatty acids or their metabolites via lipoxygenase, cyclooxygenase or epoxygenase are able to modulate (activate, inhibit or potentiate) the function of specific TRPs. Isoprene lipids, diacylglycerol, resolvin, and lysophospholipids also show distinct activities on sensory TRP channels. Outcomes caused by the interactions between sensory TRPs and lipid ligands are also discussed. The knowledge we collected here implicates that information on lipidergic ligands may contribute to our understanding of peripheral pain mechanism and provide an opportunity to design novel therapeutic strategies. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/21052930/Endogenous_lipid_derived_ligands_for_sensory_TRP_ion_channels_and_their_pain_modulation_ L2 - https://dx.doi.org/10.1007/s12272-010-1004-9 DB - PRIME DP - Unbound Medicine ER -