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New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue from Combretum yunnanense.
Planta Med. 2011 Mar; 77(5):481-4.PM

Abstract

New chalcone and dimeric chalcones with 1,4- P-benzoquinone residue, combrequinone A (1), combrequinone B (2), and combrequinone C (3), along with three known compounds (4-6), were isolated from the ethanolic extract of the stems and leaves of Combretum yunnanense, and their structures were determined by spectroscopic analysis. Compounds 1-3 were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, and SW480. Compounds 1, 2 and 3 were found to be most potent against HL-60 acute leukemia cells, with IC₅₀ values of 4.63, 4.07, and 1.26 µM, respectively.

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Authors+Show Affiliations

Wu MM
Department of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, Yunnan, P. R. China.
Wang LQ
No affiliation info available
Hua Y
No affiliation info available
Chen YG
No affiliation info available
Wang YY
No affiliation info available
Li XY
No affiliation info available
Li Y
No affiliation info available
Li T
No affiliation info available
Yang XY
No affiliation info available
Tang ZR
No affiliation info available

MeSH

BenzoquinonesCell Line, TumorCell SurvivalChalconesFernsHumansInhibitory Concentration 50Magnetic Resonance SpectroscopyPlant ExtractsPlant LeavesPlant Stems

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21053158

Citation

Wu, Ming-Mei, et al. "New Chalcone and Dimeric Chalcones With 1,4-p-benzoquinone Residue From Combretum Yunnanense." Planta Medica, vol. 77, no. 5, 2011, pp. 481-4.
Wu MM, Wang LQ, Hua Y, et al. New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue from Combretum yunnanense. Planta Med. 2011;77(5):481-4.
Wu, M. M., Wang, L. Q., Hua, Y., Chen, Y. G., Wang, Y. Y., Li, X. Y., Li, Y., Li, T., Yang, X. Y., & Tang, Z. R. (2011). New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue from Combretum yunnanense. Planta Medica, 77(5), 481-4. https://doi.org/10.1055/s-0030-1250492
Wu MM, et al. New Chalcone and Dimeric Chalcones With 1,4-p-benzoquinone Residue From Combretum Yunnanense. Planta Med. 2011;77(5):481-4. PubMed PMID: 21053158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue from Combretum yunnanense. AU - Wu,Ming-Mei, AU - Wang,Li-Qin, AU - Hua,Yan, AU - Chen,Ye-Gao, AU - Wang,Yuan-Yuan, AU - Li,Xing-Yao, AU - Li,Yan, AU - Li,Ting, AU - Yang,Xun-Yun, AU - Tang,Zheng-Rong, Y1 - 2010/11/04/ PY - 2010/11/6/entrez PY - 2010/11/6/pubmed PY - 2012/7/27/medline SP - 481 EP - 4 JF - Planta medica JO - Planta Med VL - 77 IS - 5 N2 - New chalcone and dimeric chalcones with 1,4- P-benzoquinone residue, combrequinone A (1), combrequinone B (2), and combrequinone C (3), along with three known compounds (4-6), were isolated from the ethanolic extract of the stems and leaves of Combretum yunnanense, and their structures were determined by spectroscopic analysis. Compounds 1-3 were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, and SW480. Compounds 1, 2 and 3 were found to be most potent against HL-60 acute leukemia cells, with IC₅₀ values of 4.63, 4.07, and 1.26 µM, respectively. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/21053158/New_chalcone_and_dimeric_chalcones_with_14_p_benzoquinone_residue_from_Combretum_yunnanense_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1250492 DB - PRIME DP - Unbound Medicine ER -