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Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species.
J Nat Prod. 2010 Nov 29; 73(11):1821-32.JN

Abstract

A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Pimenta EF
Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
Vita-Marques AM
No affiliation info available
Tininis A
No affiliation info available
Seleghim MH
No affiliation info available
Sette LD
No affiliation info available
Veloso K
No affiliation info available
Ferreira AG
No affiliation info available
Williams DE
No affiliation info available
Patrick BO
No affiliation info available
Dalisay DS
No affiliation info available
Andersen RJ
No affiliation info available
Berlinck RG
No affiliation info available

MeSH

AlkaloidsAnimalsAnti-Bacterial AgentsCandida albicansCaulerpaChromatography, High Pressure LiquidCrystallography, X-RayEscherichia coliFemaleHumansMarine BiologyMethicillin-Resistant Staphylococcus aureusMiceMicrobial Sensitivity TestsMolecular ConformationMolecular StructureMycobacterium tuberculosisNuclear Magnetic Resonance, BiomolecularPenicilliumPseudomonas aeruginosaResearch Design

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21053938

Citation

Pimenta, Eli F., et al. "Use of Experimental Design for the Optimization of the Production of New Secondary Metabolites By Two Penicillium Species." Journal of Natural Products, vol. 73, no. 11, 2010, pp. 1821-32.
Pimenta EF, Vita-Marques AM, Tininis A, et al. Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species. J Nat Prod. 2010;73(11):1821-32.
Pimenta, E. F., Vita-Marques, A. M., Tininis, A., Seleghim, M. H., Sette, L. D., Veloso, K., Ferreira, A. G., Williams, D. E., Patrick, B. O., Dalisay, D. S., Andersen, R. J., & Berlinck, R. G. (2010). Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species. Journal of Natural Products, 73(11), 1821-32. https://doi.org/10.1021/np100470h
Pimenta EF, et al. Use of Experimental Design for the Optimization of the Production of New Secondary Metabolites By Two Penicillium Species. J Nat Prod. 2010 Nov 29;73(11):1821-32. PubMed PMID: 21053938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species. AU - Pimenta,Eli F, AU - Vita-Marques,Aline M, AU - Tininis,Aristeu, AU - Seleghim,Mirna H R, AU - Sette,Lara D, AU - Veloso,Katyuscya, AU - Ferreira,Antonio G, AU - Williams,David E, AU - Patrick,Brian O, AU - Dalisay,Doralyn S, AU - Andersen,Raymond J, AU - Berlinck,Roberto G S, Y1 - 2010/11/05/ PY - 2010/11/9/entrez PY - 2010/11/9/pubmed PY - 2010/12/31/medline SP - 1821 EP - 32 JF - Journal of natural products JO - J Nat Prod VL - 73 IS - 11 N2 - A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/21053938/Use_of_experimental_design_for_the_optimization_of_the_production_of_new_secondary_metabolites_by_two_Penicillium_species_ L2 - https://doi.org/10.1021/np100470h DB - PRIME DP - Unbound Medicine ER -