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Biocatalytic synthesis and in vitro release of biodegradable linear polyesters with pendant ketoprofen.
Biomacromolecules 2010; 11(12):3290-3B

Abstract

Enzyme-catalyzed polycondensation for the synthesis of polyester prodrugs of ketoprofen was reported. Lipase acrylic resin from Candida antarctica (CAL-B) was used to synthesize the linear polyesters with pendent ketoprofen groups based on ketoprofen glycerol ester, poly(ethylene glycol), and divinyl sebacate. The products were characterized by GPC and (1)H NMR. The results indicated that the molecular weight and yields of the polyesters depend on experimental conditions such as temperature and feed ratio. The in vitro study showed that the drug release from the polyester was slow under physiological conditions, which indicated that the polyester could be a promising prodrug with extended pharmacological effects by delayed release of ketoprofen.

Authors+Show Affiliations

Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21053944

Citation

Wang, Hai-Yang, et al. "Biocatalytic Synthesis and in Vitro Release of Biodegradable Linear Polyesters With Pendant Ketoprofen." Biomacromolecules, vol. 11, no. 12, 2010, pp. 3290-3.
Wang HY, Zhang WW, Wang N, et al. Biocatalytic synthesis and in vitro release of biodegradable linear polyesters with pendant ketoprofen. Biomacromolecules. 2010;11(12):3290-3.
Wang, H. Y., Zhang, W. W., Wang, N., Li, C., Li, K., & Yu, X. Q. (2010). Biocatalytic synthesis and in vitro release of biodegradable linear polyesters with pendant ketoprofen. Biomacromolecules, 11(12), pp. 3290-3. doi:10.1021/bm100712k.
Wang HY, et al. Biocatalytic Synthesis and in Vitro Release of Biodegradable Linear Polyesters With Pendant Ketoprofen. Biomacromolecules. 2010 Dec 13;11(12):3290-3. PubMed PMID: 21053944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biocatalytic synthesis and in vitro release of biodegradable linear polyesters with pendant ketoprofen. AU - Wang,Hai-Yang, AU - Zhang,Wei-Wei, AU - Wang,Na, AU - Li,Chao, AU - Li,Kun, AU - Yu,Xiao-Qi, Y1 - 2010/11/05/ PY - 2010/11/9/entrez PY - 2010/11/9/pubmed PY - 2011/4/13/medline SP - 3290 EP - 3 JF - Biomacromolecules JO - Biomacromolecules VL - 11 IS - 12 N2 - Enzyme-catalyzed polycondensation for the synthesis of polyester prodrugs of ketoprofen was reported. Lipase acrylic resin from Candida antarctica (CAL-B) was used to synthesize the linear polyesters with pendent ketoprofen groups based on ketoprofen glycerol ester, poly(ethylene glycol), and divinyl sebacate. The products were characterized by GPC and (1)H NMR. The results indicated that the molecular weight and yields of the polyesters depend on experimental conditions such as temperature and feed ratio. The in vitro study showed that the drug release from the polyester was slow under physiological conditions, which indicated that the polyester could be a promising prodrug with extended pharmacological effects by delayed release of ketoprofen. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/21053944/Biocatalytic_synthesis_and_in_vitro_release_of_biodegradable_linear_polyesters_with_pendant_ketoprofen_ L2 - https://dx.doi.org/10.1021/bm100712k DB - PRIME DP - Unbound Medicine ER -