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Functionally distinct melanocyte populations revealed by reconstitution of hair follicles in mice.
Pigment Cell Melanoma Res. 2011 Feb; 24(1):125-35.PC

Abstract

Hair follicle reconstitution analysis was used to test the contribution of melanocytes or their precursors to regenerated hair follicles. In this study, we first confirmed the process of chimeric hair follicle regeneration by both hair keratinocytes and follicular melanocytes. Then, as first suggested from the differential growth requirements of epidermal skin melanocytes and non-cutaneous or dermal melanocytes, we confirmed the inability of the latter to be involved as follicular melanocytes to regenerate hair follicles during the hair reconstitution assay. This clear functional discrimination between non-cutaneous or dermal melanocytes and epidermal melanocytes suggests the presence of two different melanocyte cell lineages, a finding that might be important in the pathogenesis of melanocyte-related diseases and melanomas.

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Authors+Show Affiliations

Aoki H
Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Gifu University Graduate School of Medicine, Yanagido, Gifu, Japan.
Hara A
No affiliation info available
Motohashi T
No affiliation info available
Osawa M
No affiliation info available
Kunisada T
No affiliation info available

MeSH

AnimalsAnimals, NewbornBiological AssayChimeraDermisEndothelin-3Hair FollicleHumansKeratin-14MelanocytesMiceMice, TransgenicSkin Pigmentation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21054816

Citation

Aoki, Hitomi, et al. "Functionally Distinct Melanocyte Populations Revealed By Reconstitution of Hair Follicles in Mice." Pigment Cell & Melanoma Research, vol. 24, no. 1, 2011, pp. 125-35.
Aoki H, Hara A, Motohashi T, et al. Functionally distinct melanocyte populations revealed by reconstitution of hair follicles in mice. Pigment Cell Melanoma Res. 2011;24(1):125-35.
Aoki, H., Hara, A., Motohashi, T., Osawa, M., & Kunisada, T. (2011). Functionally distinct melanocyte populations revealed by reconstitution of hair follicles in mice. Pigment Cell & Melanoma Research, 24(1), 125-35. https://doi.org/10.1111/j.1755-148X.2010.00801.x
Aoki H, et al. Functionally Distinct Melanocyte Populations Revealed By Reconstitution of Hair Follicles in Mice. Pigment Cell Melanoma Res. 2011;24(1):125-35. PubMed PMID: 21054816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functionally distinct melanocyte populations revealed by reconstitution of hair follicles in mice. AU - Aoki,Hitomi, AU - Hara,Akira, AU - Motohashi,Tsutomu, AU - Osawa,Masatake, AU - Kunisada,Takahiro, Y1 - 2010/11/19/ PY - 2010/11/9/entrez PY - 2010/11/9/pubmed PY - 2011/4/26/medline SP - 125 EP - 35 JF - Pigment cell & melanoma research JO - Pigment Cell Melanoma Res VL - 24 IS - 1 N2 - Hair follicle reconstitution analysis was used to test the contribution of melanocytes or their precursors to regenerated hair follicles. In this study, we first confirmed the process of chimeric hair follicle regeneration by both hair keratinocytes and follicular melanocytes. Then, as first suggested from the differential growth requirements of epidermal skin melanocytes and non-cutaneous or dermal melanocytes, we confirmed the inability of the latter to be involved as follicular melanocytes to regenerate hair follicles during the hair reconstitution assay. This clear functional discrimination between non-cutaneous or dermal melanocytes and epidermal melanocytes suggests the presence of two different melanocyte cell lineages, a finding that might be important in the pathogenesis of melanocyte-related diseases and melanomas. SN - 1755-148X UR - https://www.unboundmedicine.com/medline/citation/21054816/Functionally_distinct_melanocyte_populations_revealed_by_reconstitution_of_hair_follicles_in_mice_ L2 - https://doi.org/10.1111/j.1755-148X.2010.00801.x DB - PRIME DP - Unbound Medicine ER -