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Association between serum 25-hydroxyvitamin D and psychological health in older Chinese men in a cohort study.
J Affect Disord. 2011 Apr; 130(1-2):251-9.JA

Abstract

BACKGROUND

Few studies evaluated the association between vitamin D and psychological health in Chinese. This study examined these associations in Chinese older men in Hong Kong.

METHODS

Baseline serum 25-hydroxyvitamin D (25OHD), depression and cognitive function were assessed in 939 community-dwelling Chinese men aged >65. Data on depression status at 4-year follow up was available in 629 men. Data were collected for confounding factors: demographics, number of diseases, smoking, alcohol use, body mass index, physical activity, mobility limitations, dietary intake, season of blood measurement, and serum parathyroid hormone level. Multivariate logistic regression analyses were performed with adjustments for confounding factors.

RESULTS

An inverse association between serum 25OHD and baseline depression was observed. Men in the highest (>=92 nmol/L) compared with lowest (<=63 nmol/L) quartile of serum 25OHD had an adjusted odds ratio for depression of 0.46 (95% CI: 0.22-0.98, P(trend)=0.004). The association was more pronounced in low vitamin D season than in high vitamin D season. No association was observed between serum 25OHD and incident depression at 4 years. Baseline cognitive impairment was not associated with serum 25OHD in all models.

LIMITATIONS

Self-reported measure of depression and cognitive performance, the small number of incident depression at 4-year follow up and selection bias may affect the study validity.

CONCLUSIONS

Serum 25OHD was inversely associated with depression at baseline and was not linked to baseline cognitive impairment and 4-year incident depression in Chinese older men. Future studies are warranted to evaluate these associations in populations with higher prevalence of vitamin D deficiency.

Authors+Show Affiliations

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR. ruthchansm@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21056909

Citation

Chan, Ruth, et al. "Association Between Serum 25-hydroxyvitamin D and Psychological Health in Older Chinese Men in a Cohort Study." Journal of Affective Disorders, vol. 130, no. 1-2, 2011, pp. 251-9.
Chan R, Chan D, Woo J, et al. Association between serum 25-hydroxyvitamin D and psychological health in older Chinese men in a cohort study. J Affect Disord. 2011;130(1-2):251-9.
Chan, R., Chan, D., Woo, J., Ohlsson, C., Mellström, D., Kwok, T., & Leung, P. (2011). Association between serum 25-hydroxyvitamin D and psychological health in older Chinese men in a cohort study. Journal of Affective Disorders, 130(1-2), 251-9. https://doi.org/10.1016/j.jad.2010.10.029
Chan R, et al. Association Between Serum 25-hydroxyvitamin D and Psychological Health in Older Chinese Men in a Cohort Study. J Affect Disord. 2011;130(1-2):251-9. PubMed PMID: 21056909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum 25-hydroxyvitamin D and psychological health in older Chinese men in a cohort study. AU - Chan,Ruth, AU - Chan,Dicken, AU - Woo,Jean, AU - Ohlsson,Claes, AU - Mellström,Dan, AU - Kwok,Timothy, AU - Leung,Pingchung, Y1 - 2010/11/05/ PY - 2010/08/30/received PY - 2010/10/12/revised PY - 2010/10/12/accepted PY - 2010/11/9/entrez PY - 2010/11/9/pubmed PY - 2011/7/30/medline SP - 251 EP - 9 JF - Journal of affective disorders JO - J Affect Disord VL - 130 IS - 1-2 N2 - BACKGROUND: Few studies evaluated the association between vitamin D and psychological health in Chinese. This study examined these associations in Chinese older men in Hong Kong. METHODS: Baseline serum 25-hydroxyvitamin D (25OHD), depression and cognitive function were assessed in 939 community-dwelling Chinese men aged >65. Data on depression status at 4-year follow up was available in 629 men. Data were collected for confounding factors: demographics, number of diseases, smoking, alcohol use, body mass index, physical activity, mobility limitations, dietary intake, season of blood measurement, and serum parathyroid hormone level. Multivariate logistic regression analyses were performed with adjustments for confounding factors. RESULTS: An inverse association between serum 25OHD and baseline depression was observed. Men in the highest (>=92 nmol/L) compared with lowest (<=63 nmol/L) quartile of serum 25OHD had an adjusted odds ratio for depression of 0.46 (95% CI: 0.22-0.98, P(trend)=0.004). The association was more pronounced in low vitamin D season than in high vitamin D season. No association was observed between serum 25OHD and incident depression at 4 years. Baseline cognitive impairment was not associated with serum 25OHD in all models. LIMITATIONS: Self-reported measure of depression and cognitive performance, the small number of incident depression at 4-year follow up and selection bias may affect the study validity. CONCLUSIONS: Serum 25OHD was inversely associated with depression at baseline and was not linked to baseline cognitive impairment and 4-year incident depression in Chinese older men. Future studies are warranted to evaluate these associations in populations with higher prevalence of vitamin D deficiency. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/21056909/Association_between_serum_25_hydroxyvitamin_D_and_psychological_health_in_older_Chinese_men_in_a_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(10)00643-9 DB - PRIME DP - Unbound Medicine ER -