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Coronavirus causes lower respiratory tract infections less frequently than RSV in hospitalized Norwegian children.
Pediatr Infect Dis J. 2011 Apr; 30(4):279-83.PI

Abstract

BACKGROUND

We have described occurrence and clinical manifestations of human coronaviruses (HCoV) in hospitalized Norwegian children with respiratory tract infection (RTI) and compared them with a group of respiratory syncytial virus (RSV)-infected children.

METHODS AND POPULATION

We used in-house TaqMan multiplex real-time polymerase chain reaction to test nasopharyngeal samples from 536 RTI episodes in 452 children who were admitted during the 2006-2007 winter. Twenty-one viruses, including HCoV-OC43, HCoV-NL63, HCoV-229E, HCoV-HKU1, and RSV were tested. The amount of viral nucleic acid was recorded semiquantitatively based on the cycle threshold value.

RESULTS

A total of 665 positive polymerase chain reaction tests were recorded in 536 nasopharyngeal specimens. Coronavirus was found in 68 (12.7%): HCoV-OC43, n = 44 (8.2%), and HCoV-NL63, n = 24 (4.5%). Only RSV and rhinovirus were detected more frequently. Neither HCoV-229E nor HCoV-HKU1 was detected. Among children with HCoV-OC43, 73.0% tested positive for at least one other virus, compared with 41.2% with HCoV-NL63 and 40.3% with RSV (P = 0.03 and P < 0.01, respectively). Children with HCoV-OC43 and HCoV-NL63 were older than children with RSV (median age, 19 vs. 10 months, P = 0.01). Lower respiratory tract infection (LRTI) was half as common in children with HCoV-OC43 (48.6%) and HCoV-NL63 (47.1%) as in children with RSV (82.3%) (both P < 0.01). After adjusting for age, chronic disease, LRTI, and co-detection of other viruses in a multiple logistic regression analysis, HCoV was associated with a shorter fever period and shorter hospitalization time than RSV.

CONCLUSIONS

HCoV-OC43 and HCoV-NL63 are common among hospitalized Norwegian children with RTI. Children with HCoV-OC43 and HCoV-NL63 have LRTI less frequently and may need a shorter hospital stay than children with RSV.

Authors+Show Affiliations

Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21057374

Citation

Kristoffersen, Aslak Widerøe, et al. "Coronavirus Causes Lower Respiratory Tract Infections Less Frequently Than RSV in Hospitalized Norwegian Children." The Pediatric Infectious Disease Journal, vol. 30, no. 4, 2011, pp. 279-83.
Kristoffersen AW, Nordbø SA, Rognlien AG, et al. Coronavirus causes lower respiratory tract infections less frequently than RSV in hospitalized Norwegian children. Pediatr Infect Dis J. 2011;30(4):279-83.
Kristoffersen, A. W., Nordbø, S. A., Rognlien, A. G., Christensen, A., & Døllner, H. (2011). Coronavirus causes lower respiratory tract infections less frequently than RSV in hospitalized Norwegian children. The Pediatric Infectious Disease Journal, 30(4), 279-83. https://doi.org/10.1097/INF.0b013e3181fcb159
Kristoffersen AW, et al. Coronavirus Causes Lower Respiratory Tract Infections Less Frequently Than RSV in Hospitalized Norwegian Children. Pediatr Infect Dis J. 2011;30(4):279-83. PubMed PMID: 21057374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus causes lower respiratory tract infections less frequently than RSV in hospitalized Norwegian children. AU - Kristoffersen,Aslak Widerøe, AU - Nordbø,Svein Arne, AU - Rognlien,Anne-Gro Wesenberg, AU - Christensen,Andreas, AU - Døllner,Henrik, PY - 2010/11/9/entrez PY - 2010/11/9/pubmed PY - 2011/7/16/medline SP - 279 EP - 83 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 30 IS - 4 N2 - BACKGROUND: We have described occurrence and clinical manifestations of human coronaviruses (HCoV) in hospitalized Norwegian children with respiratory tract infection (RTI) and compared them with a group of respiratory syncytial virus (RSV)-infected children. METHODS AND POPULATION: We used in-house TaqMan multiplex real-time polymerase chain reaction to test nasopharyngeal samples from 536 RTI episodes in 452 children who were admitted during the 2006-2007 winter. Twenty-one viruses, including HCoV-OC43, HCoV-NL63, HCoV-229E, HCoV-HKU1, and RSV were tested. The amount of viral nucleic acid was recorded semiquantitatively based on the cycle threshold value. RESULTS: A total of 665 positive polymerase chain reaction tests were recorded in 536 nasopharyngeal specimens. Coronavirus was found in 68 (12.7%): HCoV-OC43, n = 44 (8.2%), and HCoV-NL63, n = 24 (4.5%). Only RSV and rhinovirus were detected more frequently. Neither HCoV-229E nor HCoV-HKU1 was detected. Among children with HCoV-OC43, 73.0% tested positive for at least one other virus, compared with 41.2% with HCoV-NL63 and 40.3% with RSV (P = 0.03 and P < 0.01, respectively). Children with HCoV-OC43 and HCoV-NL63 were older than children with RSV (median age, 19 vs. 10 months, P = 0.01). Lower respiratory tract infection (LRTI) was half as common in children with HCoV-OC43 (48.6%) and HCoV-NL63 (47.1%) as in children with RSV (82.3%) (both P < 0.01). After adjusting for age, chronic disease, LRTI, and co-detection of other viruses in a multiple logistic regression analysis, HCoV was associated with a shorter fever period and shorter hospitalization time than RSV. CONCLUSIONS: HCoV-OC43 and HCoV-NL63 are common among hospitalized Norwegian children with RTI. Children with HCoV-OC43 and HCoV-NL63 have LRTI less frequently and may need a shorter hospital stay than children with RSV. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/21057374/Coronavirus_causes_lower_respiratory_tract_infections_less_frequently_than_RSV_in_hospitalized_Norwegian_children_ L2 - https://doi.org/10.1097/INF.0b013e3181fcb159 DB - PRIME DP - Unbound Medicine ER -