Tags

Type your tag names separated by a space and hit enter

Increased insulin-like growth factor-1 receptor mRNA expression predicts poor survival in immunophenotypes of early breast carcinoma.
Mod Pathol. 2011 Feb; 24(2):201-8.MP

Abstract

The biology of breast carcinoma shows a great variation, reflected by the recent classification of phenotypes based on DNA microarrays or immunohistochemistry. The aim of this study was to determine the prevalence of insulin-like growth factor-1 receptor (IGF1R) in breast carcinoma subtypes and the impact on the outcome. We studied 197 consecutive breast carcinoma patients in stage I-II treated conservatively. Phenotypes were assessed on the basis of the expressions of ER/PR, HER2, Ki67, p53, Bcl2, CK5/6 and EGFR. Moreover, IGF1R expression (α-subunit and β-phosphorylated/active form) was evaluated by immunohistochemistry, IGF1R mRNA levels by quantitative RT-PCR and IGF1R mutations by direct DNA sequencing. Overall, 40% (78/197) of tumors were luminal A, 24% (48/197) luminal B, 19% (37/197) HER2-positive and 17% (34/197) basal/triple-negative. Luminal A tumors were predominantly of low grade, without necrosis, presenting in older patients as a ≤2-cm unilateral mass (all P ≤ 0.046). α-IGF1R overexpression was observed more frequently in luminal A (49%) cases, followed by luminal B (20%), HER2-positive area under the curve (22%) and basal/triple-negative cases (9%) (P = 0.01) with similar results for mRNA levels (53, 24, 13 and 10%, respectively) (P = 0.038), but without differences for mutations (P = NS). High IGF1R mRNA correlated with poor patient survival among subtypes (P = 0.004) (Kaplan-Meier; log-rank test). For overall survival, only histological grade and IGF1R mRNA emerged as significant predictors (P ≤ 0.034; Cox regression). Increased IGF1R mRNA implies poorer patient prognosis among the different subtypes, and that may be associated with the lack of responsiveness to tamoxifen in cases with a positive hormone receptor status. Our results highlight the biological and clinical relevance of IGF1R in early breast carcinoma subtypes, and provide knowledge to assist in treatment decision.

Authors+Show Affiliations

Research Unit, Hospital General Universitari d'Alacant, Spain. peiro_glo@gva.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21057462

Citation

Peiró, Gloria, et al. "Increased Insulin-like Growth Factor-1 Receptor mRNA Expression Predicts Poor Survival in Immunophenotypes of Early Breast Carcinoma." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, vol. 24, no. 2, 2011, pp. 201-8.
Peiró G, Adrover E, Sánchez-Tejada L, et al. Increased insulin-like growth factor-1 receptor mRNA expression predicts poor survival in immunophenotypes of early breast carcinoma. Mod Pathol. 2011;24(2):201-8.
Peiró, G., Adrover, E., Sánchez-Tejada, L., Lerma, E., Planelles, M., Sánchez-Payá, J., Aranda, F. I., Giner, D., & Gutiérrez-Aviñó, F. J. (2011). Increased insulin-like growth factor-1 receptor mRNA expression predicts poor survival in immunophenotypes of early breast carcinoma. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 24(2), 201-8. https://doi.org/10.1038/modpathol.2010.191
Peiró G, et al. Increased Insulin-like Growth Factor-1 Receptor mRNA Expression Predicts Poor Survival in Immunophenotypes of Early Breast Carcinoma. Mod Pathol. 2011;24(2):201-8. PubMed PMID: 21057462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased insulin-like growth factor-1 receptor mRNA expression predicts poor survival in immunophenotypes of early breast carcinoma. AU - Peiró,Gloria, AU - Adrover,Encarna, AU - Sánchez-Tejada,Laura, AU - Lerma,Enrique, AU - Planelles,María, AU - Sánchez-Payá,José, AU - Aranda,Francisco I, AU - Giner,Daniel, AU - Gutiérrez-Aviñó,Francisco J, Y1 - 2010/11/05/ PY - 2010/11/9/entrez PY - 2010/11/9/pubmed PY - 2011/7/1/medline SP - 201 EP - 8 JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc JO - Mod Pathol VL - 24 IS - 2 N2 - The biology of breast carcinoma shows a great variation, reflected by the recent classification of phenotypes based on DNA microarrays or immunohistochemistry. The aim of this study was to determine the prevalence of insulin-like growth factor-1 receptor (IGF1R) in breast carcinoma subtypes and the impact on the outcome. We studied 197 consecutive breast carcinoma patients in stage I-II treated conservatively. Phenotypes were assessed on the basis of the expressions of ER/PR, HER2, Ki67, p53, Bcl2, CK5/6 and EGFR. Moreover, IGF1R expression (α-subunit and β-phosphorylated/active form) was evaluated by immunohistochemistry, IGF1R mRNA levels by quantitative RT-PCR and IGF1R mutations by direct DNA sequencing. Overall, 40% (78/197) of tumors were luminal A, 24% (48/197) luminal B, 19% (37/197) HER2-positive and 17% (34/197) basal/triple-negative. Luminal A tumors were predominantly of low grade, without necrosis, presenting in older patients as a ≤2-cm unilateral mass (all P ≤ 0.046). α-IGF1R overexpression was observed more frequently in luminal A (49%) cases, followed by luminal B (20%), HER2-positive area under the curve (22%) and basal/triple-negative cases (9%) (P = 0.01) with similar results for mRNA levels (53, 24, 13 and 10%, respectively) (P = 0.038), but without differences for mutations (P = NS). High IGF1R mRNA correlated with poor patient survival among subtypes (P = 0.004) (Kaplan-Meier; log-rank test). For overall survival, only histological grade and IGF1R mRNA emerged as significant predictors (P ≤ 0.034; Cox regression). Increased IGF1R mRNA implies poorer patient prognosis among the different subtypes, and that may be associated with the lack of responsiveness to tamoxifen in cases with a positive hormone receptor status. Our results highlight the biological and clinical relevance of IGF1R in early breast carcinoma subtypes, and provide knowledge to assist in treatment decision. SN - 1530-0285 UR - https://www.unboundmedicine.com/medline/citation/21057462/Increased_insulin_like_growth_factor_1_receptor_mRNA_expression_predicts_poor_survival_in_immunophenotypes_of_early_breast_carcinoma_ L2 - https://doi.org/10.1038/modpathol.2010.191 DB - PRIME DP - Unbound Medicine ER -