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Effect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgery.
Nutr Cancer 2010; 62(8):1105-12NC

Abstract

Administration of immuno-enhanced nutritional support may decrease postoperative morbidity, mortality, and infectious complications in cancer patients. The aim of this study was to verify that perioperative enteral diet, enriched with the nutrients arginine, ribonucleic acid (RNA), and ω-3 fatty acids improves outcomes of head and neck cancer patients undergoing major surgery. Forty patients with squamous cell carcinoma of the head and neck were studied. Group 1 received no preoperative nutritional support, whereas Group 2 received an oral formula with nutrients arginine, RNA, and ω-3 fatty acids. After surgery, Group 1 received a standard enteral formula, whereas Group 2 received an enriched enteral formula. Albumin (g/dl), prealbumin, fibrinogen, CRP, Il-6, and TNFa were measured 5 days before and 8 days after surgery. No statistically significant difference was observed for all the evaluated markers between postoperative and preoperative levels for both groups. The rate of complications was significantly reduced in the total number of patients receiving immunonutrition and in the particular subgroup of well-nourished patients receiving an immuno-enhanced diet. Perioperative enteral immuno-enhanced feeding in head and neck cancer patients undergoing major surgery may influence the postoperative outcomes by reducing the frequency rate of infections and wound complications.

Authors+Show Affiliations

Medical School, University of Athens, Hippokration Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21058198

Citation

Felekis, Dimitrios, et al. "Effect of Perioperative Immuno-enhanced Enteral Nutrition On Inflammatory Response, Nutritional Status, and Outcomes in Head and Neck Cancer Patients Undergoing Major Surgery." Nutrition and Cancer, vol. 62, no. 8, 2010, pp. 1105-12.
Felekis D, Eleftheriadou A, Papadakos G, et al. Effect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgery. Nutr Cancer. 2010;62(8):1105-12.
Felekis, D., Eleftheriadou, A., Papadakos, G., Bosinakou, I., Ferekidou, E., Kandiloros, D., ... Manolopoulos, L. (2010). Effect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgery. Nutrition and Cancer, 62(8), pp. 1105-12. doi:10.1080/01635581.2010.494336.
Felekis D, et al. Effect of Perioperative Immuno-enhanced Enteral Nutrition On Inflammatory Response, Nutritional Status, and Outcomes in Head and Neck Cancer Patients Undergoing Major Surgery. Nutr Cancer. 2010;62(8):1105-12. PubMed PMID: 21058198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgery. AU - Felekis,Dimitrios, AU - Eleftheriadou,Anna, AU - Papadakos,Georgios, AU - Bosinakou,Irini, AU - Ferekidou,Eliza, AU - Kandiloros,Dimitrios, AU - Katsaragakis,Stylianos, AU - Charalabopoulos,Konstantinos, AU - Manolopoulos,Leonidas, PY - 2010/11/9/entrez PY - 2010/11/9/pubmed PY - 2011/3/9/medline SP - 1105 EP - 12 JF - Nutrition and cancer JO - Nutr Cancer VL - 62 IS - 8 N2 - Administration of immuno-enhanced nutritional support may decrease postoperative morbidity, mortality, and infectious complications in cancer patients. The aim of this study was to verify that perioperative enteral diet, enriched with the nutrients arginine, ribonucleic acid (RNA), and ω-3 fatty acids improves outcomes of head and neck cancer patients undergoing major surgery. Forty patients with squamous cell carcinoma of the head and neck were studied. Group 1 received no preoperative nutritional support, whereas Group 2 received an oral formula with nutrients arginine, RNA, and ω-3 fatty acids. After surgery, Group 1 received a standard enteral formula, whereas Group 2 received an enriched enteral formula. Albumin (g/dl), prealbumin, fibrinogen, CRP, Il-6, and TNFa were measured 5 days before and 8 days after surgery. No statistically significant difference was observed for all the evaluated markers between postoperative and preoperative levels for both groups. The rate of complications was significantly reduced in the total number of patients receiving immunonutrition and in the particular subgroup of well-nourished patients receiving an immuno-enhanced diet. Perioperative enteral immuno-enhanced feeding in head and neck cancer patients undergoing major surgery may influence the postoperative outcomes by reducing the frequency rate of infections and wound complications. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/21058198/Effect_of_perioperative_immuno_enhanced_enteral_nutrition_on_inflammatory_response_nutritional_status_and_outcomes_in_head_and_neck_cancer_patients_undergoing_major_surgery_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2010.494336 DB - PRIME DP - Unbound Medicine ER -