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Dehydration, electrolyte imbalances and renin-angiotensin-aldosterone-vasopressin axis in successful and unsuccessful endurance horses.
Equine Vet J Suppl. 2010 NovEV

Abstract

REASON FOR PERFORMING STUDY

Limited information exists concerning the defence of homeostasis during endurance competitions and the relationship with performance.

OBJECTIVES

This research analysed renin (REN), angiotensin II (ANG), aldosterone (ALD) and vasopressin (AVP) in horses covering different distances, assesses differences between successful and eliminated horses and evaluates correlations between hydration status, renal function, electrolytes, REN, ANG, ALD and AVP.

METHODS

Packed cell volume (PCV), velocity and serum concentrations of REN, ANG, ALD, AVP, Na, K, Cl, Ca, Mg, P, creatine kinase, aspartate aminotransferase, lactate dehydrogenase, total proteins (TSP), albumin (ALB), serum uric nitrogen (SUN), creatinine (CREAT) and lactate were analysed in both successful horses (SH) and in horses eliminated due to metabolic problems (MH). Two types of competition were studied: 91 km in one day (Competition A: 20 SH, 9 MH) and 166 km in 2 days, 83 km/day (Competition B: 10 SH and 5 MH).

RESULTS

Research analysed renin was not affected by exercise, whereas ANG, ALD and AVP increased. In the SH group, resting ALD and AVP concentrations at the beginning of the second day of Competition B were higher than preride values. Vasopressin did not change during the second day of Competition B, whereas ALD progressively increased. Metabolic problems of both groups showed more evident dehydration (higher PCV, TSP, ALB, SUN and CREAT) and electrolyte alterations (more intense decreases of Na and Cl) than SH at the different sampling times. Metabolic problems presented higher ALD and AVP concentrations. Angiotensin II was higher at certain sampling times in the horses.

CONCLUSIONS

Endurance horses with dehydration and electrolyte disturbances showed a more intense activation of the REN-ANG-ALD-AVP axis.

POTENTIAL RELEVANCE

The study of the response of the REN-ANG-ALD-AVP axis during prolonged exercise in horses with different performance will aid to minimise the risk of metabolic diseases during competitions.

Authors+Show Affiliations

Department of Animal Medicine and Surgery, University of Córdoba, Córdoba, Spain. pv1mujua@uco.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21058987

Citation

Muñoz, A, et al. "Dehydration, Electrolyte Imbalances and Renin-angiotensin-aldosterone-vasopressin Axis in Successful and Unsuccessful Endurance Horses." Equine Veterinary Journal. Supplement, 2010, pp. 83-90.
Muñoz A, Riber C, Trigo P, et al. Dehydration, electrolyte imbalances and renin-angiotensin-aldosterone-vasopressin axis in successful and unsuccessful endurance horses. Equine Vet J Suppl. 2010.
Muñoz, A., Riber, C., Trigo, P., Castejón-Riber, C., & Castejón, F. M. (2010). Dehydration, electrolyte imbalances and renin-angiotensin-aldosterone-vasopressin axis in successful and unsuccessful endurance horses. Equine Veterinary Journal. Supplement, (38), 83-90. https://doi.org/10.1111/j.2042-3306.2010.00211.x
Muñoz A, et al. Dehydration, Electrolyte Imbalances and Renin-angiotensin-aldosterone-vasopressin Axis in Successful and Unsuccessful Endurance Horses. Equine Vet J Suppl. 2010;(38)83-90. PubMed PMID: 21058987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dehydration, electrolyte imbalances and renin-angiotensin-aldosterone-vasopressin axis in successful and unsuccessful endurance horses. AU - Muñoz,A, AU - Riber,C, AU - Trigo,P, AU - Castejón-Riber,C, AU - Castejón,F M, PY - 2010/11/10/entrez PY - 2011/5/27/pubmed PY - 2011/8/19/medline SP - 83 EP - 90 JF - Equine veterinary journal. Supplement JO - Equine Vet J Suppl IS - 38 N2 - REASON FOR PERFORMING STUDY: Limited information exists concerning the defence of homeostasis during endurance competitions and the relationship with performance. OBJECTIVES: This research analysed renin (REN), angiotensin II (ANG), aldosterone (ALD) and vasopressin (AVP) in horses covering different distances, assesses differences between successful and eliminated horses and evaluates correlations between hydration status, renal function, electrolytes, REN, ANG, ALD and AVP. METHODS: Packed cell volume (PCV), velocity and serum concentrations of REN, ANG, ALD, AVP, Na, K, Cl, Ca, Mg, P, creatine kinase, aspartate aminotransferase, lactate dehydrogenase, total proteins (TSP), albumin (ALB), serum uric nitrogen (SUN), creatinine (CREAT) and lactate were analysed in both successful horses (SH) and in horses eliminated due to metabolic problems (MH). Two types of competition were studied: 91 km in one day (Competition A: 20 SH, 9 MH) and 166 km in 2 days, 83 km/day (Competition B: 10 SH and 5 MH). RESULTS: Research analysed renin was not affected by exercise, whereas ANG, ALD and AVP increased. In the SH group, resting ALD and AVP concentrations at the beginning of the second day of Competition B were higher than preride values. Vasopressin did not change during the second day of Competition B, whereas ALD progressively increased. Metabolic problems of both groups showed more evident dehydration (higher PCV, TSP, ALB, SUN and CREAT) and electrolyte alterations (more intense decreases of Na and Cl) than SH at the different sampling times. Metabolic problems presented higher ALD and AVP concentrations. Angiotensin II was higher at certain sampling times in the horses. CONCLUSIONS: Endurance horses with dehydration and electrolyte disturbances showed a more intense activation of the REN-ANG-ALD-AVP axis. POTENTIAL RELEVANCE: The study of the response of the REN-ANG-ALD-AVP axis during prolonged exercise in horses with different performance will aid to minimise the risk of metabolic diseases during competitions. UR - https://www.unboundmedicine.com/medline/citation/21058987/Dehydration_electrolyte_imbalances_and_renin_angiotensin_aldosterone_vasopressin_axis_in_successful_and_unsuccessful_endurance_horses_ L2 - https://doi.org/10.1111/j.2042-3306.2010.00211.x DB - PRIME DP - Unbound Medicine ER -