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Stress-induced suppression of the prolactin afternoon surge in ovariectomized, estrogen-treated rats and the nocturnal surge in pseudopregnant rats are accompanied by an increase in median eminence dihydroxyphenylacetic acid concentrations.
Neuroendocrinology. 1990 Feb; 51(2):208-12.N

Abstract

Experiments were performed to determine whether the suppression of prolactin (PRL) surges during restraint was accompanied by changes in the activity of tuberoinfundibular dopamine (TIDA) neurons in the median eminence. Animals were either ovariectomized and estrogen-treated (OVX-PEP) or cervically stimulated to induce pseudopregnancy (PSP). Restraint stress was administered by tying the hind legs together with plastic-coated bell wire. Animals were decapitated following 15 or 30 min of restraint stress or immediately after removal from the animal room (control) when PRL levels were basal (10.00 h), at the peak of the afternoon PRL surge in OVX-PEP animals (17.00 h) or the nocturnal PRL surge in PSP animals (05.00 h). Median eminence dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) were significantly decreased in control rats at 17.00 h when compared to control rats at 10.00 h (103.1 +/- 3.7 vs. 85.8 +/- 3.3 and 11.4 vs. 7.1 +/- 0.4 pg/micrograms protein, respectively) and plasma PRL was markedly elevated. Restraint stress at 10.00 h resulted in a significant increase in serum PRL, but this increase was not accompanied by a change in DA or DOPAC when compared to control animals (103.1 +/- 3.7 vs. 107.9 +/- 4.8 and 11.4 +/- 0.4 vs. 10.4 +/- 0.6 pg/micrograms protein, respectively).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Physiology, Wayne State University, School of Medicine, Detroit, Mich.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2106099

Citation

Morehead, M H., et al. "Stress-induced Suppression of the Prolactin Afternoon Surge in Ovariectomized, Estrogen-treated Rats and the Nocturnal Surge in Pseudopregnant Rats Are Accompanied By an Increase in Median Eminence Dihydroxyphenylacetic Acid Concentrations." Neuroendocrinology, vol. 51, no. 2, 1990, pp. 208-12.
Morehead MH, Lookingland KJ, Gala RR. Stress-induced suppression of the prolactin afternoon surge in ovariectomized, estrogen-treated rats and the nocturnal surge in pseudopregnant rats are accompanied by an increase in median eminence dihydroxyphenylacetic acid concentrations. Neuroendocrinology. 1990;51(2):208-12.
Morehead, M. H., Lookingland, K. J., & Gala, R. R. (1990). Stress-induced suppression of the prolactin afternoon surge in ovariectomized, estrogen-treated rats and the nocturnal surge in pseudopregnant rats are accompanied by an increase in median eminence dihydroxyphenylacetic acid concentrations. Neuroendocrinology, 51(2), 208-12.
Morehead MH, Lookingland KJ, Gala RR. Stress-induced Suppression of the Prolactin Afternoon Surge in Ovariectomized, Estrogen-treated Rats and the Nocturnal Surge in Pseudopregnant Rats Are Accompanied By an Increase in Median Eminence Dihydroxyphenylacetic Acid Concentrations. Neuroendocrinology. 1990;51(2):208-12. PubMed PMID: 2106099.
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TY - JOUR T1 - Stress-induced suppression of the prolactin afternoon surge in ovariectomized, estrogen-treated rats and the nocturnal surge in pseudopregnant rats are accompanied by an increase in median eminence dihydroxyphenylacetic acid concentrations. AU - Morehead,M H, AU - Lookingland,K J, AU - Gala,R R, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - 208 EP - 12 JF - Neuroendocrinology JO - Neuroendocrinology VL - 51 IS - 2 N2 - Experiments were performed to determine whether the suppression of prolactin (PRL) surges during restraint was accompanied by changes in the activity of tuberoinfundibular dopamine (TIDA) neurons in the median eminence. Animals were either ovariectomized and estrogen-treated (OVX-PEP) or cervically stimulated to induce pseudopregnancy (PSP). Restraint stress was administered by tying the hind legs together with plastic-coated bell wire. Animals were decapitated following 15 or 30 min of restraint stress or immediately after removal from the animal room (control) when PRL levels were basal (10.00 h), at the peak of the afternoon PRL surge in OVX-PEP animals (17.00 h) or the nocturnal PRL surge in PSP animals (05.00 h). Median eminence dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) were significantly decreased in control rats at 17.00 h when compared to control rats at 10.00 h (103.1 +/- 3.7 vs. 85.8 +/- 3.3 and 11.4 vs. 7.1 +/- 0.4 pg/micrograms protein, respectively) and plasma PRL was markedly elevated. Restraint stress at 10.00 h resulted in a significant increase in serum PRL, but this increase was not accompanied by a change in DA or DOPAC when compared to control animals (103.1 +/- 3.7 vs. 107.9 +/- 4.8 and 11.4 +/- 0.4 vs. 10.4 +/- 0.6 pg/micrograms protein, respectively).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0028-3835 UR - https://www.unboundmedicine.com/medline/citation/2106099/Stress_induced_suppression_of_the_prolactin_afternoon_surge_in_ovariectomized_estrogen_treated_rats_and_the_nocturnal_surge_in_pseudopregnant_rats_are_accompanied_by_an_increase_in_median_eminence_dihydroxyphenylacetic_acid_concentrations_ L2 - https://www.karger.com?DOI=10.1159/000125339 DB - PRIME DP - Unbound Medicine ER -