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Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures.
Pharmacol Biochem Behav. 2011 Jan; 97(3):531-6.PB

Abstract

Alpha-lipoic acid has some neuroprotective properties, but this action has not been investigated in models of epilepsy. The aim of the present study was to investigate the protective efficacy of α-lipoic acid (lipoic acid) against pilocarpine-induced cell death through the caspase-dependent or -independent mitochondrial apoptotic pathways. Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400 mg/kg, pilocarpine group) alone, or α-lipoic acid (20 mg/kg) in association with pilocarpine (400 mg/kg) 30 min before administration of α-lipoic acid. After the treatments all groups were observed for 24 h. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. Our study suggests that lipoic acid inhibits both caspase-dependent and -independent apoptotic pathways and may be neuroprotective against hippocampal damage during pilocarpine-induced seizures.

Authors+Show Affiliations

Laboratory of Research in Experimental Neurochemistry of Federal University of Piaui, Piaui, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21062633

Citation

dos Santos, Pauline Sousa, et al. "Lipoic Acid Inhibits Caspase-dependent and -independent Cell Death Pathways and Is Neuroprotective Against Hippocampal Damage After Pilocarpine-induced Seizures." Pharmacology, Biochemistry, and Behavior, vol. 97, no. 3, 2011, pp. 531-6.
dos Santos PS, Feitosa CM, Saldanha GB, et al. Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures. Pharmacol Biochem Behav. 2011;97(3):531-6.
dos Santos, P. S., Feitosa, C. M., Saldanha, G. B., Tomé, A. d. a. . R., Feng, D., & de Freitas, R. M. (2011). Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures. Pharmacology, Biochemistry, and Behavior, 97(3), 531-6. https://doi.org/10.1016/j.pbb.2010.11.001
dos Santos PS, et al. Lipoic Acid Inhibits Caspase-dependent and -independent Cell Death Pathways and Is Neuroprotective Against Hippocampal Damage After Pilocarpine-induced Seizures. Pharmacol Biochem Behav. 2011;97(3):531-6. PubMed PMID: 21062633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures. AU - dos Santos,Pauline Sousa, AU - Feitosa,Chistiane Mendes, AU - Saldanha,Gláucio Barros, AU - Tomé,Adriana da Rocha, AU - Feng,Dejiang, AU - de Freitas,Rivelilson Mendes, Y1 - 2010/11/06/ PY - 2010/10/08/received PY - 2010/10/31/revised PY - 2010/11/01/accepted PY - 2010/11/11/entrez PY - 2010/11/11/pubmed PY - 2011/4/13/medline SP - 531 EP - 6 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 97 IS - 3 N2 - Alpha-lipoic acid has some neuroprotective properties, but this action has not been investigated in models of epilepsy. The aim of the present study was to investigate the protective efficacy of α-lipoic acid (lipoic acid) against pilocarpine-induced cell death through the caspase-dependent or -independent mitochondrial apoptotic pathways. Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400 mg/kg, pilocarpine group) alone, or α-lipoic acid (20 mg/kg) in association with pilocarpine (400 mg/kg) 30 min before administration of α-lipoic acid. After the treatments all groups were observed for 24 h. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. Our study suggests that lipoic acid inhibits both caspase-dependent and -independent apoptotic pathways and may be neuroprotective against hippocampal damage during pilocarpine-induced seizures. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/21062633/Lipoic_acid_inhibits_caspase_dependent_and__independent_cell_death_pathways_and_is_neuroprotective_against_hippocampal_damage_after_pilocarpine_induced_seizures_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(10)00339-4 DB - PRIME DP - Unbound Medicine ER -