The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects.Prog Neuropsychopharmacol Biol Psychiatry 2011; 35(1):198-202PN
Abstract
BACKGROUND
Interactions between glutamatergic and endocannabinoid systems may contribute to schizophrenia, dissociative states, and other psychiatric conditions. Cannabidiol (CBD), a cannabinoid-1/2 (CB1/2) receptor weak partial agonist or antagonist, may play a role in the treatment of schizophrenia.
OBJECTIVE
This study tested the hypothesis that CBD would attenuate the behavioral effects of the NMDA receptor antagonist, ketamine, in healthy human subjects.
METHODS
Ten male healthy volunteers were evaluated twice in a randomized order. In both sessions they received ketamine (bolus of 0.26 mg/kg/1 min followed by IV infusion of 0.25mg/kg over 30 min) preceded by either CBD (600 mg) or placebo. Psychopathology was assessed using the Brief Psychiatric Rating Scale (BPRS) and the CADSS (Clinician Administered Dissociative States Scale) at regular intervals from 30 min before to 90 min after ketamine administration.
RESULTS
CBD significantly augmented the activating effects of ketamine, as measured by the activation subscales of the BPRS. However, CBD also showed a non-significant trend to reduce ketamine-induced depersonalization, as measured by the CADSS.
CONCLUSION
These data describe a complex pattern of psychopharmacologic interactions between CBD and ketamine at the doses of each agent studied in this experiment.
MeSH
Pub Type(s)
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Language
eng
PubMed ID
21062637
Citation
Hallak, Jaime E C., et al. "The Interplay of Cannabinoid and NMDA Glutamate Receptor Systems in Humans: Preliminary Evidence of Interactive Effects of Cannabidiol and Ketamine in Healthy Human Subjects." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 35, no. 1, 2011, pp. 198-202.
Hallak JE, Dursun SM, Bosi DC, et al. The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(1):198-202.
Hallak, J. E., Dursun, S. M., Bosi, D. C., de Macedo, L. R., Machado-de-Sousa, J. P., Abrão, J., ... Zuardi, A. W. (2011). The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects. Progress in Neuro-psychopharmacology & Biological Psychiatry, 35(1), pp. 198-202. doi:10.1016/j.pnpbp.2010.11.002.
Hallak JE, et al. The Interplay of Cannabinoid and NMDA Glutamate Receptor Systems in Humans: Preliminary Evidence of Interactive Effects of Cannabidiol and Ketamine in Healthy Human Subjects. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):198-202. PubMed PMID: 21062637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects.
AU - Hallak,Jaime E C,
AU - Dursun,Serdar M,
AU - Bosi,Daniel C,
AU - de Macedo,Ligia Ribeiro Horta,
AU - Machado-de-Sousa,João Paulo,
AU - Abrão,João,
AU - Crippa,José A S,
AU - McGuire,Phillip,
AU - Krystal,John H,
AU - Baker,Glen B,
AU - Zuardi,Antonio W,
Y1 - 2010/11/07/
PY - 2010/06/01/received
PY - 2010/11/01/revised
PY - 2010/11/01/accepted
PY - 2010/11/11/entrez
PY - 2010/11/11/pubmed
PY - 2011/5/4/medline
SP - 198
EP - 202
JF - Progress in neuro-psychopharmacology & biological psychiatry
JO - Prog. Neuropsychopharmacol. Biol. Psychiatry
VL - 35
IS - 1
N2 - BACKGROUND: Interactions between glutamatergic and endocannabinoid systems may contribute to schizophrenia, dissociative states, and other psychiatric conditions. Cannabidiol (CBD), a cannabinoid-1/2 (CB1/2) receptor weak partial agonist or antagonist, may play a role in the treatment of schizophrenia. OBJECTIVE: This study tested the hypothesis that CBD would attenuate the behavioral effects of the NMDA receptor antagonist, ketamine, in healthy human subjects. METHODS: Ten male healthy volunteers were evaluated twice in a randomized order. In both sessions they received ketamine (bolus of 0.26 mg/kg/1 min followed by IV infusion of 0.25mg/kg over 30 min) preceded by either CBD (600 mg) or placebo. Psychopathology was assessed using the Brief Psychiatric Rating Scale (BPRS) and the CADSS (Clinician Administered Dissociative States Scale) at regular intervals from 30 min before to 90 min after ketamine administration. RESULTS: CBD significantly augmented the activating effects of ketamine, as measured by the activation subscales of the BPRS. However, CBD also showed a non-significant trend to reduce ketamine-induced depersonalization, as measured by the CADSS. CONCLUSION: These data describe a complex pattern of psychopharmacologic interactions between CBD and ketamine at the doses of each agent studied in this experiment.
SN - 1878-4216
UR - https://www.unboundmedicine.com/medline/citation/21062637/abstract/The_interplay_of_cannabinoid_and_NMDA_glutamate_receptor_systems_in_humans:_preliminary_evidence_of_interactive_effects_of_cannabidiol_and_ketamine_in_healthy_human_subjects_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(10)00416-1
DB - PRIME
DP - Unbound Medicine
ER -
