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Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status--the Japan public health center-based prospective study.

Abstract

Few prospective studies have investigated the association between BMI at age 20 years (BMI20y) and breast cancer risk with consideration to estrogen/progesterone receptor status (ER/PR). We evaluated the association between BMI20y and ER/PR-defined breast cancer risk among 41,594 women in the population-based Japan Public Health Center-based Prospective Study. Anthropometric factors were assessed using self-reported questionnaires. Relative risks (RRs) were estimated by Cox proportional hazards regression models. Through to the end of 2006, 452 breast cancer cases were identified. We observed a statistically significant inverse association between BMI20y and breast cancer incidence [multivariable-adjusted RR for each 5-unit increment 0.75 (95%CI=0.61-0.92)], which was not modified by menopausal or recent BMI status. In contrast, recent BMI and subsequent BMI gain were not associated with increased risk among premenopausal women, but were substantially associated with increased risk among postmenopausal women [corresponding RR(recent BMI)=1.31 (95%CI=1.07-1.59); RR(subsequent BMI gain)=1.32 (95%CI=1.09-1.60)]. In subanalyses by receptor status (∼50% of cases), the observed inverse association of BMI20y with risk was consistent with the result for ER-PR- [0.49 (95%CI=0.27-0.88)], while the observed positive associations of BMI gain with postmenopausal breast cancer risk appeared to be confined to ER+PR+ tumors [corresponding RR(for subsequent BMI gain)=2.24 (95%CI=1.50-3.34)]. Low BMI at age 20 years was substantially associated with an increased risk of breast cancer. In contrast, high recent BMI and subsequent BMI gain from age 20 were associated with increased risk of postmenopausal ER+PR+ tumors.

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  • Authors+Show Affiliations

    ,

    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.

    , , , , , , ,

    Source

    International journal of cancer 129:5 2011 Sep 01 pg 1214-24

    MeSH

    Adolescent
    Adult
    Age Factors
    Body Mass Index
    Body Weight
    Breast Neoplasms
    Cohort Studies
    Female
    Follow-Up Studies
    Humans
    Incidence
    Japan
    Middle Aged
    Obesity
    Prognosis
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Risk Factors
    Survival Rate
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21064092

    Citation

    Suzuki, Reiko, et al. "Body Weight at Age 20 Years, Subsequent Weight Change and Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status--the Japan Public Health Center-based Prospective Study." International Journal of Cancer, vol. 129, no. 5, 2011, pp. 1214-24.
    Suzuki R, Iwasaki M, Inoue M, et al. Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status--the Japan public health center-based prospective study. Int J Cancer. 2011;129(5):1214-24.
    Suzuki, R., Iwasaki, M., Inoue, M., Sasazuki, S., Sawada, N., Yamaji, T., ... Tsugane, S. (2011). Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status--the Japan public health center-based prospective study. International Journal of Cancer, 129(5), pp. 1214-24. doi:10.1002/ijc.25744.
    Suzuki R, et al. Body Weight at Age 20 Years, Subsequent Weight Change and Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status--the Japan Public Health Center-based Prospective Study. Int J Cancer. 2011 Sep 1;129(5):1214-24. PubMed PMID: 21064092.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status--the Japan public health center-based prospective study. AU - Suzuki,Reiko, AU - Iwasaki,Motoki, AU - Inoue,Manami, AU - Sasazuki,Shizuka, AU - Sawada,Norie, AU - Yamaji,Taiki, AU - Shimazu,Taichi, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2011/04/08/ PY - 2010/03/17/received PY - 2010/09/30/accepted PY - 2010/11/11/entrez PY - 2010/11/11/pubmed PY - 2011/9/29/medline SP - 1214 EP - 24 JF - International journal of cancer JO - Int. J. Cancer VL - 129 IS - 5 N2 - Few prospective studies have investigated the association between BMI at age 20 years (BMI20y) and breast cancer risk with consideration to estrogen/progesterone receptor status (ER/PR). We evaluated the association between BMI20y and ER/PR-defined breast cancer risk among 41,594 women in the population-based Japan Public Health Center-based Prospective Study. Anthropometric factors were assessed using self-reported questionnaires. Relative risks (RRs) were estimated by Cox proportional hazards regression models. Through to the end of 2006, 452 breast cancer cases were identified. We observed a statistically significant inverse association between BMI20y and breast cancer incidence [multivariable-adjusted RR for each 5-unit increment 0.75 (95%CI=0.61-0.92)], which was not modified by menopausal or recent BMI status. In contrast, recent BMI and subsequent BMI gain were not associated with increased risk among premenopausal women, but were substantially associated with increased risk among postmenopausal women [corresponding RR(recent BMI)=1.31 (95%CI=1.07-1.59); RR(subsequent BMI gain)=1.32 (95%CI=1.09-1.60)]. In subanalyses by receptor status (∼50% of cases), the observed inverse association of BMI20y with risk was consistent with the result for ER-PR- [0.49 (95%CI=0.27-0.88)], while the observed positive associations of BMI gain with postmenopausal breast cancer risk appeared to be confined to ER+PR+ tumors [corresponding RR(for subsequent BMI gain)=2.24 (95%CI=1.50-3.34)]. Low BMI at age 20 years was substantially associated with an increased risk of breast cancer. In contrast, high recent BMI and subsequent BMI gain from age 20 were associated with increased risk of postmenopausal ER+PR+ tumors. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21064092/Body_weight_at_age_20_years_subsequent_weight_change_and_breast_cancer_risk_defined_by_estrogen_and_progesterone_receptor_status__the_Japan_public_health_center_based_prospective_study_ L2 - https://doi.org/10.1002/ijc.25744 DB - PRIME DP - Unbound Medicine ER -