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Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong.

Abstract

BACKGROUND

The relationship between seasonal influenza vaccine and susceptibility to 2009 pandemic A/H1N1 virus infection is not fully understood.

METHODS

One child 6-15 years of age from each of 119 households was randomized to receive 1 dose of inactivated trivalent seasonal influenza vaccine (TIV) or saline placebo in November 2008. Serum samples were collected from study subjects and their household contacts before and 1 month after vaccination (December 2008), after winter (April 2009) and summer influenza (September-October 2009) seasons. Seasonal and pandemic influenza were confirmed by serum hemagglutinination inhibition, viral neutralization titers, and reverse-transcription polymerase chain reaction performed on nasal and throat swab samples collected during illness episodes.

RESULTS

TIV recipients had lower rates of serologically confirmed seasonal A/H1N1 infection (TIV group, 8%; placebo group, 21%; P=.10) and A/H3N2 infection (7% vs 12%; P=A9), but higher rates of pandemic A/H1N1 infection (32% vs 17%; [Formula: see text]). In multivariable analysis, those infected with seasonal influenza A during the study had a lower risk of laboratory-confirmed pandemic A/H1N1 infection (adjusted odds ratio [OR], 0.35; 95% confidence interval [CI], 0.14-0.87), and receipt of seasonal TIV was unassociated with risk of pandemic A/H1N1 infection (adjusted OR, 1.11; 95% CI, 0.54-2.26).

CONCLUSIONS

TIV protected against strain-matched infection in children. Seasonal influenza infection appeared to confer cross-protection against pandemic influenza. Whether prior seasonal influenza vaccination affects the risk of infection with the pandemic strain requires additional study.

CLINICAL TRIALS REGISTRATION

ClinicalTrials.gov number NCT00792051 .

Links

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  • Authors+Show Affiliations

    ,

    Infectious Disease Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. bcowling@hku.hk

    , , , , , , , , ,

    Source

    MeSH

    Adolescent
    Antibodies, Neutralizing
    Antibodies, Viral
    Child
    Cross Protection
    Female
    Hemagglutination Inhibition Tests
    Hong Kong
    Humans
    Influenza Vaccines
    Influenza, Human
    Male
    Neutralization Tests
    Nose
    Orthomyxoviridae
    Pandemics
    Pharynx
    Placebos
    RNA, Viral
    Reverse Transcriptase Polymerase Chain Reaction
    Vaccination
    Vaccines, Inactivated

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21067351

    Citation

    Cowling, Benjamin J., et al. "Protective Efficacy of Seasonal Influenza Vaccination Against Seasonal and Pandemic Influenza Virus Infection During 2009 in Hong Kong." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 51, no. 12, 2010, pp. 1370-9.
    Cowling BJ, Ng S, Ma ES, et al. Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong. Clin Infect Dis. 2010;51(12):1370-9.
    Cowling, B. J., Ng, S., Ma, E. S., Cheng, C. K., Wai, W., Fang, V. J., ... Leung, G. M. (2010). Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 51(12), pp. 1370-9. doi:10.1086/657311.
    Cowling BJ, et al. Protective Efficacy of Seasonal Influenza Vaccination Against Seasonal and Pandemic Influenza Virus Infection During 2009 in Hong Kong. Clin Infect Dis. 2010 Dec 15;51(12):1370-9. PubMed PMID: 21067351.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong. AU - Cowling,Benjamin J, AU - Ng,Sophia, AU - Ma,Edward S K, AU - Cheng,Calvin K Y, AU - Wai,Winnie, AU - Fang,Vicky J, AU - Chan,Kwok-Hung, AU - Ip,Dennis K M, AU - Chiu,Susan S, AU - Peiris,J S Malik, AU - Leung,Gabriel M, Y1 - 2010/11/10/ PY - 2010/11/12/entrez PY - 2010/11/12/pubmed PY - 2011/2/26/medline SP - 1370 EP - 9 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 51 IS - 12 N2 - BACKGROUND: The relationship between seasonal influenza vaccine and susceptibility to 2009 pandemic A/H1N1 virus infection is not fully understood. METHODS: One child 6-15 years of age from each of 119 households was randomized to receive 1 dose of inactivated trivalent seasonal influenza vaccine (TIV) or saline placebo in November 2008. Serum samples were collected from study subjects and their household contacts before and 1 month after vaccination (December 2008), after winter (April 2009) and summer influenza (September-October 2009) seasons. Seasonal and pandemic influenza were confirmed by serum hemagglutinination inhibition, viral neutralization titers, and reverse-transcription polymerase chain reaction performed on nasal and throat swab samples collected during illness episodes. RESULTS: TIV recipients had lower rates of serologically confirmed seasonal A/H1N1 infection (TIV group, 8%; placebo group, 21%; P=.10) and A/H3N2 infection (7% vs 12%; P=A9), but higher rates of pandemic A/H1N1 infection (32% vs 17%; [Formula: see text]). In multivariable analysis, those infected with seasonal influenza A during the study had a lower risk of laboratory-confirmed pandemic A/H1N1 infection (adjusted odds ratio [OR], 0.35; 95% confidence interval [CI], 0.14-0.87), and receipt of seasonal TIV was unassociated with risk of pandemic A/H1N1 infection (adjusted OR, 1.11; 95% CI, 0.54-2.26). CONCLUSIONS: TIV protected against strain-matched infection in children. Seasonal influenza infection appeared to confer cross-protection against pandemic influenza. Whether prior seasonal influenza vaccination affects the risk of infection with the pandemic strain requires additional study. CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov number NCT00792051 . SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/21067351/Protective_efficacy_of_seasonal_influenza_vaccination_against_seasonal_and_pandemic_influenza_virus_infection_during_2009_in_Hong_Kong_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/657311 DB - PRIME DP - Unbound Medicine ER -