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Optimization of extraction of evodiamine and rutaecarpine from fruit of Evodia rutaecarpa using modified supercritical CO(2).
J Chromatogr A. 2010 Dec 10; 1217(50):7833-9.JC

Abstract

Evodiamine and rutaecarpine have been intensively studied due to their pharmacological actions and clinical applications. In this report, supercritical fluid was used to extract evodiamine and rutaecarpine from the unripe fruit of Evodia rutaecarpa. Response surface methodology using Box-Behnken experimental design was utilized to optimize parameters for supercritical carbon dioxide extraction with methanol as co-solvent. The effect of various values of dynamic extraction time (30-90min), temperature (50-70°C) and pressure (200-400bar) on extraction yields of the two compounds was evaluated. Determinations of the extracts were performed by high-performance liquid chromatography. The experimental data obtained were fitted to second-order polynomial equations and analyzed by analysis of variance. The highest yields predicted were 1.217mg/g for evodiamine and 0.969mg/g for rutaecarpine at the optimal values (time 78min, temperature 62°C, pressure 280bar and co-solvent flow rate 0.4mL/min), based on the selected range of experimental conditions.

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Authors+Show Affiliations

Liu B
Department of Bioengineering and Pharmaceutics, Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, China. liu_ben0@hotmail.com
Guo F
No affiliation info available
Chang Y
No affiliation info available
Jiang H
No affiliation info available
Wang Q
No affiliation info available

MeSH

AlgorithmsAnalysis of VarianceCarbon DioxideChemical FractionationChromatography, High Pressure LiquidEvodiaFruitIndole AlkaloidsMethanolPlant ExtractsPressureQuinazolinesTemperatureTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21067761

Citation

Liu, Ben, et al. "Optimization of Extraction of Evodiamine and Rutaecarpine From Fruit of Evodia Rutaecarpa Using Modified Supercritical CO(2)." Journal of Chromatography. A, vol. 1217, no. 50, 2010, pp. 7833-9.
Liu B, Guo F, Chang Y, et al. Optimization of extraction of evodiamine and rutaecarpine from fruit of Evodia rutaecarpa using modified supercritical CO(2). J Chromatogr A. 2010;1217(50):7833-9.
Liu, B., Guo, F., Chang, Y., Jiang, H., & Wang, Q. (2010). Optimization of extraction of evodiamine and rutaecarpine from fruit of Evodia rutaecarpa using modified supercritical CO(2). Journal of Chromatography. A, 1217(50), 7833-9. https://doi.org/10.1016/j.chroma.2010.10.079
Liu B, et al. Optimization of Extraction of Evodiamine and Rutaecarpine From Fruit of Evodia Rutaecarpa Using Modified Supercritical CO(2). J Chromatogr A. 2010 Dec 10;1217(50):7833-9. PubMed PMID: 21067761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimization of extraction of evodiamine and rutaecarpine from fruit of Evodia rutaecarpa using modified supercritical CO(2). AU - Liu,Ben, AU - Guo,Feng, AU - Chang,Yiling, AU - Jiang,Hailiang, AU - Wang,Qiang, Y1 - 2010/10/23/ PY - 2010/04/27/received PY - 2010/09/15/revised PY - 2010/10/18/accepted PY - 2010/11/12/entrez PY - 2010/11/12/pubmed PY - 2011/3/12/medline SP - 7833 EP - 9 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1217 IS - 50 N2 - Evodiamine and rutaecarpine have been intensively studied due to their pharmacological actions and clinical applications. In this report, supercritical fluid was used to extract evodiamine and rutaecarpine from the unripe fruit of Evodia rutaecarpa. Response surface methodology using Box-Behnken experimental design was utilized to optimize parameters for supercritical carbon dioxide extraction with methanol as co-solvent. The effect of various values of dynamic extraction time (30-90min), temperature (50-70°C) and pressure (200-400bar) on extraction yields of the two compounds was evaluated. Determinations of the extracts were performed by high-performance liquid chromatography. The experimental data obtained were fitted to second-order polynomial equations and analyzed by analysis of variance. The highest yields predicted were 1.217mg/g for evodiamine and 0.969mg/g for rutaecarpine at the optimal values (time 78min, temperature 62°C, pressure 280bar and co-solvent flow rate 0.4mL/min), based on the selected range of experimental conditions. SN - 1873-3778 UR - https://www.unboundmedicine.com/medline/citation/21067761/Optimization_of_extraction_of_evodiamine_and_rutaecarpine_from_fruit_of_Evodia_rutaecarpa_using_modified_supercritical_CO_2__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(10)01457-3 DB - PRIME DP - Unbound Medicine ER -