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Combined effects of soy isoflavone and fish oil on ovariectomy-induced bone loss in mice.
J Bone Miner Metab 2011; 29(4):404-13JB

Abstract

Both soy isoflavone and n-3 polyunsaturated fatty acids are known to reduce the levels of bone-resorbing cytokines; however, the synergistic effects of these food ingredients have not been examined yet. This study was performed to elucidate the effect of concomitant intake of soy isoflavone and fish oil on bone mass in ovariectomized mice. Eight-week-old ddY female mice were subjected to ovariectomy (OVX) or sham surgery, and then fed an AIN-93G with safflower oil (So) as a control lipid source, isoflavone-supplemented safflower oil (So + I), fish oil instead of safflower oil (Fo) or isoflavone-supplemented fish oil (Fo + I) for 4 weeks. Femoral bone mineral density was significantly decreased by OVX; however, this decrease was inhibited by the intake of isoflavone and/or fish oil. Histomorphometric analyses showed that bone volume and trabecular thickness in the distal femoral trabecular bone were significantly lower in the So group than in the sham group, but those were restored in the Fo + I groups. The number of osteoclasts was significantly decreased by isoflavone intake. The increased rate of bone resorption after OVX was inhibited by isoflavone and/or fish oil. The serum concentration of tumor necrosis factor alpha was increased after OVX, but was significantly lower with the combination of isoflavone with fish oil than isoflavone or fish oil alone. The results of this study indicated that the intakes of soy isoflavone and/or fish oil might have ameliorating effects on bone loss due to OVX. Further, the concomitant intake of soy isoflavone and fish oil at a low dose showed better effects on cytokines related with bone resorption.

Authors+Show Affiliations

Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University, 1-1, Keyakidai, Sakado, Saitama 350-0295, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21069546

Citation

Uchida, Raina, et al. "Combined Effects of Soy Isoflavone and Fish Oil On Ovariectomy-induced Bone Loss in Mice." Journal of Bone and Mineral Metabolism, vol. 29, no. 4, 2011, pp. 404-13.
Uchida R, Chiba H, Ishimi Y, et al. Combined effects of soy isoflavone and fish oil on ovariectomy-induced bone loss in mice. J Bone Miner Metab. 2011;29(4):404-13.
Uchida, R., Chiba, H., Ishimi, Y., Uehara, M., Suzuki, K., Kim, H., & Matsumoto, A. (2011). Combined effects of soy isoflavone and fish oil on ovariectomy-induced bone loss in mice. Journal of Bone and Mineral Metabolism, 29(4), pp. 404-13. doi:10.1007/s00774-010-0234-8.
Uchida R, et al. Combined Effects of Soy Isoflavone and Fish Oil On Ovariectomy-induced Bone Loss in Mice. J Bone Miner Metab. 2011;29(4):404-13. PubMed PMID: 21069546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effects of soy isoflavone and fish oil on ovariectomy-induced bone loss in mice. AU - Uchida,Raina, AU - Chiba,Hiroshige, AU - Ishimi,Yoshiko, AU - Uehara,Mariko, AU - Suzuki,Kazuharu, AU - Kim,Hyounju, AU - Matsumoto,Akiyo, Y1 - 2010/11/12/ PY - 2009/12/12/received PY - 2010/09/21/accepted PY - 2010/11/12/entrez PY - 2010/11/12/pubmed PY - 2011/11/2/medline SP - 404 EP - 13 JF - Journal of bone and mineral metabolism JO - J. Bone Miner. Metab. VL - 29 IS - 4 N2 - Both soy isoflavone and n-3 polyunsaturated fatty acids are known to reduce the levels of bone-resorbing cytokines; however, the synergistic effects of these food ingredients have not been examined yet. This study was performed to elucidate the effect of concomitant intake of soy isoflavone and fish oil on bone mass in ovariectomized mice. Eight-week-old ddY female mice were subjected to ovariectomy (OVX) or sham surgery, and then fed an AIN-93G with safflower oil (So) as a control lipid source, isoflavone-supplemented safflower oil (So + I), fish oil instead of safflower oil (Fo) or isoflavone-supplemented fish oil (Fo + I) for 4 weeks. Femoral bone mineral density was significantly decreased by OVX; however, this decrease was inhibited by the intake of isoflavone and/or fish oil. Histomorphometric analyses showed that bone volume and trabecular thickness in the distal femoral trabecular bone were significantly lower in the So group than in the sham group, but those were restored in the Fo + I groups. The number of osteoclasts was significantly decreased by isoflavone intake. The increased rate of bone resorption after OVX was inhibited by isoflavone and/or fish oil. The serum concentration of tumor necrosis factor alpha was increased after OVX, but was significantly lower with the combination of isoflavone with fish oil than isoflavone or fish oil alone. The results of this study indicated that the intakes of soy isoflavone and/or fish oil might have ameliorating effects on bone loss due to OVX. Further, the concomitant intake of soy isoflavone and fish oil at a low dose showed better effects on cytokines related with bone resorption. SN - 1435-5604 UR - https://www.unboundmedicine.com/medline/citation/21069546/Combined_effects_of_soy_isoflavone_and_fish_oil_on_ovariectomy_induced_bone_loss_in_mice_ L2 - https://dx.doi.org/10.1007/s00774-010-0234-8 DB - PRIME DP - Unbound Medicine ER -