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Topographic movie of intracranial ictal high-frequency oscillations with seizure semiology: epileptic network in Jacksonian seizures.
Epilepsia. 2011 Jan; 52(1):75-83.E

Abstract

PURPOSE

We developed a technique to produce images of dynamic changes in ictal high-frequency oscillations (HFOs) >40 Hz recorded on subdural electroencephalography (EEG) that are time-locked to the ictal EEG and ictal semiology video. We applied this technique to Jacksonian seizures to demonstrate ictal HFO propagation along the homunculus in the primary sensory-motor cortex to visualize the underlying epileptic network.

METHODS

We analyzed intracranial ictal EEGs from two patients with intractable Jacksonian seizures who underwent epilepsy surgery. We calculated the degrees of increase in amplitude within 40-80, 80-200, and 200-300 Hz frequency bands compared to the interictal period and converted them into topographic movies projected onto the brain surface picture. We combined these data with the ictal EEGs and video of the patient demonstrating ictal semiology.

KEY FINDINGS

The ictal HFOs began in the sensory cortex and appeared concomitantly with the sensory aura. They then propagated to the motor cortex at the same time that focal motor symptoms evolved. As the seizure progressed, the ictal HFOs spread or reverberated in the rolandic region. However, even when the seizure became secondarily generalized, the ictal HFOs were confined to the rolandic region. In both cases, there was increased amplitude of higher frequency bands during seizure initiation compared to seizure progression.

SIGNIFICANCE

This combined movie showed the ictal HFO propagation corresponding to the ictal semiology in Jacksonian seizures and revealed the epileptic network involved in seizure initiation and progression. This method may advance understanding of neural network activities relating to clinical seizure generation and propagation.

Authors+Show Affiliations

Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21070217

Citation

Akiyama, Tomoyuki, et al. "Topographic Movie of Intracranial Ictal High-frequency Oscillations With Seizure Semiology: Epileptic Network in Jacksonian Seizures." Epilepsia, vol. 52, no. 1, 2011, pp. 75-83.
Akiyama T, Chan DW, Go CY, et al. Topographic movie of intracranial ictal high-frequency oscillations with seizure semiology: epileptic network in Jacksonian seizures. Epilepsia. 2011;52(1):75-83.
Akiyama, T., Chan, D. W., Go, C. Y., Ochi, A., Elliott, I. M., Donner, E. J., Weiss, S. K., Snead, O. C., Rutka, J. T., Drake, J. M., & Otsubo, H. (2011). Topographic movie of intracranial ictal high-frequency oscillations with seizure semiology: epileptic network in Jacksonian seizures. Epilepsia, 52(1), 75-83. https://doi.org/10.1111/j.1528-1167.2010.02776.x
Akiyama T, et al. Topographic Movie of Intracranial Ictal High-frequency Oscillations With Seizure Semiology: Epileptic Network in Jacksonian Seizures. Epilepsia. 2011;52(1):75-83. PubMed PMID: 21070217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topographic movie of intracranial ictal high-frequency oscillations with seizure semiology: epileptic network in Jacksonian seizures. AU - Akiyama,Tomoyuki, AU - Chan,Derrick W, AU - Go,Cristina Y, AU - Ochi,Ayako, AU - Elliott,Irene M, AU - Donner,Elizabeth J, AU - Weiss,Shelly K, AU - Snead,O Carter,3rd AU - Rutka,James T, AU - Drake,James M, AU - Otsubo,Hiroshi, Y1 - 2010/11/10/ PY - 2010/11/13/entrez PY - 2010/11/13/pubmed PY - 2011/2/15/medline SP - 75 EP - 83 JF - Epilepsia JO - Epilepsia VL - 52 IS - 1 N2 - PURPOSE: We developed a technique to produce images of dynamic changes in ictal high-frequency oscillations (HFOs) >40 Hz recorded on subdural electroencephalography (EEG) that are time-locked to the ictal EEG and ictal semiology video. We applied this technique to Jacksonian seizures to demonstrate ictal HFO propagation along the homunculus in the primary sensory-motor cortex to visualize the underlying epileptic network. METHODS: We analyzed intracranial ictal EEGs from two patients with intractable Jacksonian seizures who underwent epilepsy surgery. We calculated the degrees of increase in amplitude within 40-80, 80-200, and 200-300 Hz frequency bands compared to the interictal period and converted them into topographic movies projected onto the brain surface picture. We combined these data with the ictal EEGs and video of the patient demonstrating ictal semiology. KEY FINDINGS: The ictal HFOs began in the sensory cortex and appeared concomitantly with the sensory aura. They then propagated to the motor cortex at the same time that focal motor symptoms evolved. As the seizure progressed, the ictal HFOs spread or reverberated in the rolandic region. However, even when the seizure became secondarily generalized, the ictal HFOs were confined to the rolandic region. In both cases, there was increased amplitude of higher frequency bands during seizure initiation compared to seizure progression. SIGNIFICANCE: This combined movie showed the ictal HFO propagation corresponding to the ictal semiology in Jacksonian seizures and revealed the epileptic network involved in seizure initiation and progression. This method may advance understanding of neural network activities relating to clinical seizure generation and propagation. SN - 1528-1167 UR - https://www.unboundmedicine.com/medline/citation/21070217/Topographic_movie_of_intracranial_ictal_high_frequency_oscillations_with_seizure_semiology:_epileptic_network_in_Jacksonian_seizures_ L2 - https://doi.org/10.1111/j.1528-1167.2010.02776.x DB - PRIME DP - Unbound Medicine ER -