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The role of obesity as a modifying factor in patients undergoing non-surgical periodontal therapy.
J Periodontol. 2011 May; 82(5):676-82.JP

Abstract

BACKGROUND

Earlier studies have shown an association between obesity and periodontitis, which is mediated by cytokine production. The aim of this study is to assess the role of obesity as a modifying factor on periodontal clinical parameters and on circulating proinflammatory cytokine levels in subjects undergoing non-surgical periodontal treatment.

METHODS

Twenty-seven obese subjects and 25 normal-weight subjects were enrolled in this study. Subjects in both groups had generalized chronic periodontitis. The periodontal parameters measured before and 3 months after non-surgical periodontal therapy were: visible plaque index, bleeding gingival index, bleeding on probing, probing depth, and clinical attachment level. In addition, subjects underwent anthropometric measurements and serum analyses of fasting glucose, glycated hemoglobin, interleukin-1β, interleukin-6, tumor necrosis factor-α, and interferon-γ.

RESULTS

Periodontal therapy significantly decreased visible plaque index, bleeding gingival index, bleeding on probing, probing depth of 4 to 6 mm, probing depth ≥7 mm, clinical attachment level of 4 to 6 mm, and clinical attachment level ≥7 mm in both groups (P ≤0.05). Circulating proinflammatory cytokines significantly decreased in obese and normal-weight subjects after periodontal treatment (P ≤0.05). However, interleukin-6 and tumor necrosis factor-α levels remained higher in obese subjects 3 months after treatment (P ≤0.05).

CONCLUSION

Obesity does not seem to play a negative role by interfering in the improvement of the periodontal clinical response or decreasing circulating proinflammatory cytokine levels after periodontal treatment.

Authors+Show Affiliations

Department of Master of Dental Science Course, School of Dentistry, Educational Foundation of Barretos (UNIFEB), Barretos, Brazil. elizangelazuza@yahoo.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21073330

Citation

Zuza, Elizangela P., et al. "The Role of Obesity as a Modifying Factor in Patients Undergoing Non-surgical Periodontal Therapy." Journal of Periodontology, vol. 82, no. 5, 2011, pp. 676-82.
Zuza EP, Barroso EM, Carrareto AL, et al. The role of obesity as a modifying factor in patients undergoing non-surgical periodontal therapy. J Periodontol. 2011;82(5):676-82.
Zuza, E. P., Barroso, E. M., Carrareto, A. L., Pires, J. R., Carlos, I. Z., Theodoro, L. H., & Toledo, B. E. (2011). The role of obesity as a modifying factor in patients undergoing non-surgical periodontal therapy. Journal of Periodontology, 82(5), 676-82. https://doi.org/10.1902/jop.2010.100545
Zuza EP, et al. The Role of Obesity as a Modifying Factor in Patients Undergoing Non-surgical Periodontal Therapy. J Periodontol. 2011;82(5):676-82. PubMed PMID: 21073330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of obesity as a modifying factor in patients undergoing non-surgical periodontal therapy. AU - Zuza,Elizangela P, AU - Barroso,Eliane M, AU - Carrareto,Ana Luiza V, AU - Pires,Juliana R, AU - Carlos,Iracilda Z, AU - Theodoro,Letícia H, AU - Toledo,Benedicto Egbert C, Y1 - 2010/11/12/ PY - 2010/11/16/entrez PY - 2010/11/16/pubmed PY - 2011/9/23/medline SP - 676 EP - 82 JF - Journal of periodontology JO - J. Periodontol. VL - 82 IS - 5 N2 - BACKGROUND: Earlier studies have shown an association between obesity and periodontitis, which is mediated by cytokine production. The aim of this study is to assess the role of obesity as a modifying factor on periodontal clinical parameters and on circulating proinflammatory cytokine levels in subjects undergoing non-surgical periodontal treatment. METHODS: Twenty-seven obese subjects and 25 normal-weight subjects were enrolled in this study. Subjects in both groups had generalized chronic periodontitis. The periodontal parameters measured before and 3 months after non-surgical periodontal therapy were: visible plaque index, bleeding gingival index, bleeding on probing, probing depth, and clinical attachment level. In addition, subjects underwent anthropometric measurements and serum analyses of fasting glucose, glycated hemoglobin, interleukin-1β, interleukin-6, tumor necrosis factor-α, and interferon-γ. RESULTS: Periodontal therapy significantly decreased visible plaque index, bleeding gingival index, bleeding on probing, probing depth of 4 to 6 mm, probing depth ≥7 mm, clinical attachment level of 4 to 6 mm, and clinical attachment level ≥7 mm in both groups (P ≤0.05). Circulating proinflammatory cytokines significantly decreased in obese and normal-weight subjects after periodontal treatment (P ≤0.05). However, interleukin-6 and tumor necrosis factor-α levels remained higher in obese subjects 3 months after treatment (P ≤0.05). CONCLUSION: Obesity does not seem to play a negative role by interfering in the improvement of the periodontal clinical response or decreasing circulating proinflammatory cytokine levels after periodontal treatment. SN - 1943-3670 UR - https://www.unboundmedicine.com/medline/citation/21073330/The_role_of_obesity_as_a_modifying_factor_in_patients_undergoing_non_surgical_periodontal_therapy_ L2 - https://doi.org/10.1902/jop.2010.100545 DB - PRIME DP - Unbound Medicine ER -