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The bed nucleus of the stria terminalis is required for the expression of contextual but not auditory freezing in rats with basolateral amygdala lesions.
Neurobiol Learn Mem. 2011 Feb; 95(2):199-205.NL

Abstract

Previous data suggest that overtraining can overcome fear conditioning deficits in rats with lesions of the basolateral complex of the amygdala (BLA). We have previously shown that the central nucleus of the amygdala (CEA) is essential for the acquisition and expression of conditional fear to both contextual and auditory conditioned stimuli (CSs) after overtraining. This provides strong evidence that the CEA can compensate for the loss of the BLA. Another brain area that may compensate for the loss of the BLA is the bed nucleus of the stria terminalis (BNST). We explored this possibility by examining the consequences of lesions or reversible inactivation of the BNST on the expression of overtrained fear in rats with BLA lesions. We demonstrate that lesions or inactivation of the BNST block the expression of freezing to the conditioning context, but not to an auditory conditional stimulus. These results reveal that the BNST has a critical role in the expression of contextual fear, but not fear to an auditory CS, and is therefore not the essential locus of compensation for fear learning in the absence of the BLA.

Authors+Show Affiliations

Neuroscience Program, University of Michigan, Ann Arbor, MI 48109-1043, United States.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21073972

Citation

Zimmerman, Joshua M., and Stephen Maren. "The Bed Nucleus of the Stria Terminalis Is Required for the Expression of Contextual but Not Auditory Freezing in Rats With Basolateral Amygdala Lesions." Neurobiology of Learning and Memory, vol. 95, no. 2, 2011, pp. 199-205.
Zimmerman JM, Maren S. The bed nucleus of the stria terminalis is required for the expression of contextual but not auditory freezing in rats with basolateral amygdala lesions. Neurobiol Learn Mem. 2011;95(2):199-205.
Zimmerman, J. M., & Maren, S. (2011). The bed nucleus of the stria terminalis is required for the expression of contextual but not auditory freezing in rats with basolateral amygdala lesions. Neurobiology of Learning and Memory, 95(2), 199-205. https://doi.org/10.1016/j.nlm.2010.11.002
Zimmerman JM, Maren S. The Bed Nucleus of the Stria Terminalis Is Required for the Expression of Contextual but Not Auditory Freezing in Rats With Basolateral Amygdala Lesions. Neurobiol Learn Mem. 2011;95(2):199-205. PubMed PMID: 21073972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The bed nucleus of the stria terminalis is required for the expression of contextual but not auditory freezing in rats with basolateral amygdala lesions. AU - Zimmerman,Joshua M, AU - Maren,Stephen, Y1 - 2010/11/10/ PY - 2010/07/08/received PY - 2010/09/10/revised PY - 2010/11/04/accepted PY - 2010/11/16/entrez PY - 2010/11/16/pubmed PY - 2011/7/21/medline SP - 199 EP - 205 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 95 IS - 2 N2 - Previous data suggest that overtraining can overcome fear conditioning deficits in rats with lesions of the basolateral complex of the amygdala (BLA). We have previously shown that the central nucleus of the amygdala (CEA) is essential for the acquisition and expression of conditional fear to both contextual and auditory conditioned stimuli (CSs) after overtraining. This provides strong evidence that the CEA can compensate for the loss of the BLA. Another brain area that may compensate for the loss of the BLA is the bed nucleus of the stria terminalis (BNST). We explored this possibility by examining the consequences of lesions or reversible inactivation of the BNST on the expression of overtrained fear in rats with BLA lesions. We demonstrate that lesions or inactivation of the BNST block the expression of freezing to the conditioning context, but not to an auditory conditional stimulus. These results reveal that the BNST has a critical role in the expression of contextual fear, but not fear to an auditory CS, and is therefore not the essential locus of compensation for fear learning in the absence of the BLA. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/21073972/The_bed_nucleus_of_the_stria_terminalis_is_required_for_the_expression_of_contextual_but_not_auditory_freezing_in_rats_with_basolateral_amygdala_lesions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(10)00187-5 DB - PRIME DP - Unbound Medicine ER -