Tags

Type your tag names separated by a space and hit enter

An azole-resistant isolate of Malassezia pachydermatis.
Vet Microbiol. 2011 Apr 21; 149(1-2):288-90.VM

Abstract

Canine Malassezia dermatitis (MD) is frequently treated with systemic ketoconazole (KTZ) and itaconazole (ITZ). However, the antifungal susceptibility of clinical isolates of M. pachydermatis from dogs and cats to the azoles has not been well investigated. In the present study, the in vitro susceptibility of the standard strain (CBS1879: the neotype strain of M. pachydermatis) and 29 clinical isolates of M. pachydermatis to the azoles was measured by a modified CLSI M27-A2 test using modified Dixon medium as well as by the E-test. The minimum inhibitory concentrations (MICs) of the 30 isolates of M. pachydermatis (including the neotype strain) against KTZ and ITZ were <0.03 μg/ml by the two methods. The MICs of 1 clinical isolate (ASC-11) were 1 and 2 μg/ml against KTZ, and 2 and 8 μg/ml against ITZ, by the modified CLSI M27-A2 test and the E-test, respectively. Thus, isolate ASC-11 may be resistant to these azoles, making this the first report of a resistant isolate of M. pachydermatis to KTZ and ITZ.

Authors+Show Affiliations

Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21074337

Citation

Nijima, Misako, et al. "An Azole-resistant Isolate of Malassezia Pachydermatis." Veterinary Microbiology, vol. 149, no. 1-2, 2011, pp. 288-90.
Nijima M, Kano R, Nagata M, et al. An azole-resistant isolate of Malassezia pachydermatis. Vet Microbiol. 2011;149(1-2):288-90.
Nijima, M., Kano, R., Nagata, M., Hasegawa, A., & Kamata, H. (2011). An azole-resistant isolate of Malassezia pachydermatis. Veterinary Microbiology, 149(1-2), 288-90. https://doi.org/10.1016/j.vetmic.2010.10.010
Nijima M, et al. An Azole-resistant Isolate of Malassezia Pachydermatis. Vet Microbiol. 2011 Apr 21;149(1-2):288-90. PubMed PMID: 21074337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An azole-resistant isolate of Malassezia pachydermatis. AU - Nijima,Misako, AU - Kano,Rui, AU - Nagata,Masahiko, AU - Hasegawa,Atsuhiko, AU - Kamata,Hiroshi, Y1 - 2010/10/21/ PY - 2010/05/05/received PY - 2010/10/09/revised PY - 2010/10/12/accepted PY - 2010/11/16/entrez PY - 2010/11/16/pubmed PY - 2011/5/19/medline SP - 288 EP - 90 JF - Veterinary microbiology JO - Vet. Microbiol. VL - 149 IS - 1-2 N2 - Canine Malassezia dermatitis (MD) is frequently treated with systemic ketoconazole (KTZ) and itaconazole (ITZ). However, the antifungal susceptibility of clinical isolates of M. pachydermatis from dogs and cats to the azoles has not been well investigated. In the present study, the in vitro susceptibility of the standard strain (CBS1879: the neotype strain of M. pachydermatis) and 29 clinical isolates of M. pachydermatis to the azoles was measured by a modified CLSI M27-A2 test using modified Dixon medium as well as by the E-test. The minimum inhibitory concentrations (MICs) of the 30 isolates of M. pachydermatis (including the neotype strain) against KTZ and ITZ were <0.03 μg/ml by the two methods. The MICs of 1 clinical isolate (ASC-11) were 1 and 2 μg/ml against KTZ, and 2 and 8 μg/ml against ITZ, by the modified CLSI M27-A2 test and the E-test, respectively. Thus, isolate ASC-11 may be resistant to these azoles, making this the first report of a resistant isolate of M. pachydermatis to KTZ and ITZ. SN - 1873-2542 UR - https://www.unboundmedicine.com/medline/citation/21074337/An_azole_resistant_isolate_of_Malassezia_pachydermatis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(10)00497-9 DB - PRIME DP - Unbound Medicine ER -