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Intestinal absorption of forsythoside A in different compositions of Shuang-Huang-Lian.
Fitoterapia. 2011 Apr; 82(3):375-82.F

Abstract

Shuang-Huang-Lian (SHL), a traditional Chinese formula containing Lonicerae japonicae flos (LJF), Scutellariae radix (SR) and Forsythiae fructus (FF), is commonly used to treat acute upper respiratory tract infection, acute bronchitis and light pneumonia. Forsythoside A is one of the main active ingredients in Forsythiae fructus, a key herb in SHL. In the present study, effects of different compositions in SHL on the intestinal absorption of forsythoside A were investigated. The observations from in situ intestinal circulation model showed that A/%(h(-1)) of forsythoside A in FF+LSF, FF+SR and SHL were all reduced greatly compared with that in FF. However, in pharmacokinetics study, C(max) and AUC(0→1440) of forsythoside A all increased and T(1/2) prolonged in SHL, FF+LJF and FF+SR compared with FF. The results indicated that the different compositions of SHL decreased absorption but increased bioavailability of forsythoside A, which may be related to its metabolism inhibited in intestine or liver.

Authors+Show Affiliations

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21075181

Citation

Zhou, Wei, et al. "Intestinal Absorption of Forsythoside a in Different Compositions of Shuang-Huang-Lian." Fitoterapia, vol. 82, no. 3, 2011, pp. 375-82.
Zhou W, Di LQ, Shan JJ, et al. Intestinal absorption of forsythoside A in different compositions of Shuang-Huang-Lian. Fitoterapia. 2011;82(3):375-82.
Zhou, W., Di, L. Q., Shan, J. J., Bi, X. L., Chen, L. T., & Wang, L. C. (2011). Intestinal absorption of forsythoside A in different compositions of Shuang-Huang-Lian. Fitoterapia, 82(3), 375-82. https://doi.org/10.1016/j.fitote.2010.11.012
Zhou W, et al. Intestinal Absorption of Forsythoside a in Different Compositions of Shuang-Huang-Lian. Fitoterapia. 2011;82(3):375-82. PubMed PMID: 21075181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal absorption of forsythoside A in different compositions of Shuang-Huang-Lian. AU - Zhou,Wei, AU - Di,Liu-qing, AU - Shan,Jin-jun, AU - Bi,Xiao-lin, AU - Chen,Le-tian, AU - Wang,Ling-chong, Y1 - 2010/11/12/ PY - 2010/10/15/received PY - 2010/10/20/revised PY - 2010/11/03/accepted PY - 2010/11/16/entrez PY - 2010/11/16/pubmed PY - 2011/9/7/medline SP - 375 EP - 82 JF - Fitoterapia JO - Fitoterapia VL - 82 IS - 3 N2 - Shuang-Huang-Lian (SHL), a traditional Chinese formula containing Lonicerae japonicae flos (LJF), Scutellariae radix (SR) and Forsythiae fructus (FF), is commonly used to treat acute upper respiratory tract infection, acute bronchitis and light pneumonia. Forsythoside A is one of the main active ingredients in Forsythiae fructus, a key herb in SHL. In the present study, effects of different compositions in SHL on the intestinal absorption of forsythoside A were investigated. The observations from in situ intestinal circulation model showed that A/%(h(-1)) of forsythoside A in FF+LSF, FF+SR and SHL were all reduced greatly compared with that in FF. However, in pharmacokinetics study, C(max) and AUC(0→1440) of forsythoside A all increased and T(1/2) prolonged in SHL, FF+LJF and FF+SR compared with FF. The results indicated that the different compositions of SHL decreased absorption but increased bioavailability of forsythoside A, which may be related to its metabolism inhibited in intestine or liver. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/21075181/Intestinal_absorption_of_forsythoside_A_in_different_compositions_of_Shuang_Huang_Lian_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(10)00292-3 DB - PRIME DP - Unbound Medicine ER -