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The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update.
Lupus. 2011 Jan; 20(1):51-7.L

Abstract

The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across 11 comparative studies. Meta-analysis showed an association between the PTPN22 1858T allele and SLE in all study subjects (odds ratio (OR) 1.560, 95% confidence interval (CI) 1.336, 1.822, p = 2.0 × 10(-8)). Analysis after stratification by ethnicity indicated that the PTPN22 1858T allele was significantly associated with SLE in Europeans and Hispanics (OR 1.490, 95% CI 1.280, 1.735, p = 2.0 ×10(-8); OR 2.355, 95% CI 1.644, 3.373, p = 2.9 × 10(-6)). The meta-analysis showed that the C/T + T/T genotype was associated with susceptibility to SLE in all study subjects, Europeans, and Hispanics populations, and an association between the T/T genotype with SLE in Europeans. African Americans had a much lower prevalence of the T allele (2.2%) than any other population studied, and Europeans had the highest frequency (9.5%). In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.

Authors+Show Affiliations

Korea University College of Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21078766

Citation

Lea, W W., and Y H. Lee. "The Association Between the PTPN22 C1858T Polymorphism and Systemic Lupus Erythematosus: a Meta-analysis Update." Lupus, vol. 20, no. 1, 2011, pp. 51-7.
Lea WW, Lee YH. The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update. Lupus. 2011;20(1):51-7.
Lea, W. W., & Lee, Y. H. (2011). The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update. Lupus, 20(1), 51-7. https://doi.org/10.1177/0961203310381774
Lea WW, Lee YH. The Association Between the PTPN22 C1858T Polymorphism and Systemic Lupus Erythematosus: a Meta-analysis Update. Lupus. 2011;20(1):51-7. PubMed PMID: 21078766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update. AU - Lea,W W, AU - Lee,Y H, Y1 - 2010/11/15/ PY - 2010/11/17/entrez PY - 2010/11/17/pubmed PY - 2011/4/20/medline SP - 51 EP - 7 JF - Lupus JO - Lupus VL - 20 IS - 1 N2 - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across 11 comparative studies. Meta-analysis showed an association between the PTPN22 1858T allele and SLE in all study subjects (odds ratio (OR) 1.560, 95% confidence interval (CI) 1.336, 1.822, p = 2.0 × 10(-8)). Analysis after stratification by ethnicity indicated that the PTPN22 1858T allele was significantly associated with SLE in Europeans and Hispanics (OR 1.490, 95% CI 1.280, 1.735, p = 2.0 ×10(-8); OR 2.355, 95% CI 1.644, 3.373, p = 2.9 × 10(-6)). The meta-analysis showed that the C/T + T/T genotype was associated with susceptibility to SLE in all study subjects, Europeans, and Hispanics populations, and an association between the T/T genotype with SLE in Europeans. African Americans had a much lower prevalence of the T allele (2.2%) than any other population studied, and Europeans had the highest frequency (9.5%). In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. SN - 1477-0962 UR - https://www.unboundmedicine.com/medline/citation/21078766/The_association_between_the_PTPN22_C1858T_polymorphism_and_systemic_lupus_erythematosus:_a_meta_analysis_update_ L2 - http://journals.sagepub.com/doi/full/10.1177/0961203310381774?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -