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Dietary intake of vitamin D and cognition in older women: a large population-based study.
Neurology 2010; 75(20):1810-6Neur

Abstract

BACKGROUND

Serum vitamin D concentrations are associated with global cognitive function among older adults. The benefits of vitamin D intake to treat or prevent cognitive impairment remain unknown. The objective of this cross-sectional study was to determine whether weekly dietary intake of vitamin D could be associated with global cognitive performance among older adults.

METHODS

A total of 5,596 community-dwelling women (mean age 80.5 ± 0.1 years) free of vitamin D drug supplements from the Epidémiologie de l'Ostéoporose (EPIDOS) study were divided into 2 groups according to baseline weekly vitamin D dietary intake (either inadequate <35 μg/wk or recommended ≥35μg/wk). Weekly vitamin D dietary intakes were estimated from a self-administered food frequency questionnaire. Cognitive impairment was defined as a Pfeiffer Short Portable Mental State Questionnaire (SPMSQ) score <8. Age, body mass index, sun exposure at midday, season, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and education level were considered as potential confounders.

RESULTS

Compared to women with recommended weekly vitamin D dietary intakes (n = 4,802; mean age 80.4 ± 3.8 years), women with inadequate intakes (n = 794; mean age 81.0 ± 3.8 years) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score <8 (p = 0.002). We found an association between weekly vitamin D dietary intake and SPMSQ score (β = 0.002, p < 0.001). Inadequate weekly vitamin D dietary intakes were also associated with cognitive impairment (unadjusted odds ratio = 1.42 with p = 0.002; full adjusted odds ratio = 1.30 with p = 0.024).

CONCLUSIONS

Weekly dietary intake of vitamin D was associated with cognitive performance in older women.

Authors+Show Affiliations

Department of Internal Medicine and Geriatrics, Angers University Hospital, Angers University Memory Center, UPRES EA 2646, University of Angers, UNAM, Angers, France. CeAnnweiler@chu-angers.fr

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21079183

Citation

Annweiler, C, et al. "Dietary Intake of Vitamin D and Cognition in Older Women: a Large Population-based Study." Neurology, vol. 75, no. 20, 2010, pp. 1810-6.
Annweiler C, Schott AM, Rolland Y, et al. Dietary intake of vitamin D and cognition in older women: a large population-based study. Neurology. 2010;75(20):1810-6.
Annweiler, C., Schott, A. M., Rolland, Y., Blain, H., Herrmann, F. R., & Beauchet, O. (2010). Dietary intake of vitamin D and cognition in older women: a large population-based study. Neurology, 75(20), pp. 1810-6. doi:10.1212/WNL.0b013e3181fd6352.
Annweiler C, et al. Dietary Intake of Vitamin D and Cognition in Older Women: a Large Population-based Study. Neurology. 2010 Nov 16;75(20):1810-6. PubMed PMID: 21079183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of vitamin D and cognition in older women: a large population-based study. AU - Annweiler,C, AU - Schott,A M, AU - Rolland,Y, AU - Blain,H, AU - Herrmann,F R, AU - Beauchet,O, PY - 2010/11/17/entrez PY - 2010/11/17/pubmed PY - 2010/12/16/medline SP - 1810 EP - 6 JF - Neurology JO - Neurology VL - 75 IS - 20 N2 - BACKGROUND: Serum vitamin D concentrations are associated with global cognitive function among older adults. The benefits of vitamin D intake to treat or prevent cognitive impairment remain unknown. The objective of this cross-sectional study was to determine whether weekly dietary intake of vitamin D could be associated with global cognitive performance among older adults. METHODS: A total of 5,596 community-dwelling women (mean age 80.5 ± 0.1 years) free of vitamin D drug supplements from the Epidémiologie de l'Ostéoporose (EPIDOS) study were divided into 2 groups according to baseline weekly vitamin D dietary intake (either inadequate <35 μg/wk or recommended ≥35μg/wk). Weekly vitamin D dietary intakes were estimated from a self-administered food frequency questionnaire. Cognitive impairment was defined as a Pfeiffer Short Portable Mental State Questionnaire (SPMSQ) score <8. Age, body mass index, sun exposure at midday, season, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and education level were considered as potential confounders. RESULTS: Compared to women with recommended weekly vitamin D dietary intakes (n = 4,802; mean age 80.4 ± 3.8 years), women with inadequate intakes (n = 794; mean age 81.0 ± 3.8 years) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score <8 (p = 0.002). We found an association between weekly vitamin D dietary intake and SPMSQ score (β = 0.002, p < 0.001). Inadequate weekly vitamin D dietary intakes were also associated with cognitive impairment (unadjusted odds ratio = 1.42 with p = 0.002; full adjusted odds ratio = 1.30 with p = 0.024). CONCLUSIONS: Weekly dietary intake of vitamin D was associated with cognitive performance in older women. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/21079183/Dietary_intake_of_vitamin_D_and_cognition_in_older_women:_a_large_population_based_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=21079183 DB - PRIME DP - Unbound Medicine ER -