TY - JOUR T1 - Comparative efficacy of narrow-band ultraviolet B phototherapy alone and its combination with topical 8-methoxypsoralen in psoriasis. AU - Jain,V K, AU - Jangra,Shobhna, AU - Aggarwal,K, PY - 2010/11/17/entrez PY - 2010/11/17/pubmed PY - 2011/10/14/medline SP - 666 EP - 70 JF - Indian journal of dermatology, venereology and leprology JO - Indian J Dermatol Venereol Leprol VL - 76 IS - 6 N2 - BACKGROUND: Very few studies using the combination of topical 8-methoxypsoralen (8-MOP) and narrow-band ultraviolet B (NBUVB) have been performed, especially in Indian patients. A combination of oral psoralen with NBUVB has been shown to have a superior efficacy as compared with NBUVB alone in psoriasis. AIMS: Comparison of the efficacy of topical psoralen NBUVB (combination) versus NBUVB alone in psoriasis. METHODS: Thirty patients with plaque psoriasis were taken up for the study and NBUVB phototherapy was given twice weekly. The target lesions on one side were treated with 0.1% topical 8-MOP 15 min before the irradiation. The treatment period was 12 weeks or 24 exposures. RESULTS: The number of treatment sessions and cumulative NBUVB doses were lower in the combination therapy as compared with NBUVB monotherapy, although the differences were not statistically significant. CONCLUSION: To conclude, topical 8-MOP enhances the therapeutic effects of NBUVB therapy without increasing the incidence of adverse effects. SN - 0973-3922 UR - https://www.unboundmedicine.com/medline/citation/21079310/Comparative_efficacy_of_narrow_band_ultraviolet_B_phototherapy_alone_and_its_combination_with_topical_8_methoxypsoralen_in_psoriasis_ L2 - http://www.ijdvl.com/article.asp?issn=0378-6323;year=2010;volume=76;issue=6;spage=666;epage=670;aulast=Jain DB - PRIME DP - Unbound Medicine ER -