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Elevation of hormone-binding globulins in acute intermittent porphyria.
Clin Chim Acta. 1990 Feb 28; 187(2):141-8.CC

Abstract

Sex hormone-binding globulin (SHBG), thyroxine-binding globulin (TBG) and cortisol-binding globulin (CBG) were measured in plasma of 26 patients with acute intermittent porphyria (AIP). Twelve patients had clinically manifest disease and all had elevated SHBG levels. All but one of 14 patients with latent porphyria had normal SHBG levels. TBG was elevated in 9 of the patients with clinically manifest porphyria and CBG elevated in three. Levels of TBG and CBG were either normal or only slightly elevated in those with latent porphyria. In a prospective study of 30 attacks of AIP in 7 patients, SHBG levels fell between admission and discharge, the fall being significant in the group of 21 attacks treated with haem arginate (p less than 0.001). Our findings suggest that a close correlation exists between elevated SHBG and clinical expression of AIP.

Authors+Show Affiliations

University Department of Medicine, Gardiner Institute, Western Infirmary, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2107988

Citation

Herrick, A L., et al. "Elevation of Hormone-binding Globulins in Acute Intermittent Porphyria." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 187, no. 2, 1990, pp. 141-8.
Herrick AL, McColl KE, Wallace AM, et al. Elevation of hormone-binding globulins in acute intermittent porphyria. Clin Chim Acta. 1990;187(2):141-8.
Herrick, A. L., McColl, K. E., Wallace, A. M., Moore, M. R., & Goldberg, A. (1990). Elevation of hormone-binding globulins in acute intermittent porphyria. Clinica Chimica Acta; International Journal of Clinical Chemistry, 187(2), 141-8.
Herrick AL, et al. Elevation of Hormone-binding Globulins in Acute Intermittent Porphyria. Clin Chim Acta. 1990 Feb 28;187(2):141-8. PubMed PMID: 2107988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevation of hormone-binding globulins in acute intermittent porphyria. AU - Herrick,A L, AU - McColl,K E, AU - Wallace,A M, AU - Moore,M R, AU - Goldberg,A, PY - 1990/2/28/pubmed PY - 1990/2/28/medline PY - 1990/2/28/entrez SP - 141 EP - 8 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 187 IS - 2 N2 - Sex hormone-binding globulin (SHBG), thyroxine-binding globulin (TBG) and cortisol-binding globulin (CBG) were measured in plasma of 26 patients with acute intermittent porphyria (AIP). Twelve patients had clinically manifest disease and all had elevated SHBG levels. All but one of 14 patients with latent porphyria had normal SHBG levels. TBG was elevated in 9 of the patients with clinically manifest porphyria and CBG elevated in three. Levels of TBG and CBG were either normal or only slightly elevated in those with latent porphyria. In a prospective study of 30 attacks of AIP in 7 patients, SHBG levels fell between admission and discharge, the fall being significant in the group of 21 attacks treated with haem arginate (p less than 0.001). Our findings suggest that a close correlation exists between elevated SHBG and clinical expression of AIP. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/2107988/Elevation_of_hormone_binding_globulins_in_acute_intermittent_porphyria_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0009-8981(90)90340-X DB - PRIME DP - Unbound Medicine ER -