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Electrospun nanofibrous polycaprolactone scaffolds for tissue engineering of annulus fibrosus.
Macromol Biosci 2011; 11(3):391-9MB

Abstract

The annulus fibrosus comprises concentric lamellae that can be damaged due to intervertebral disc degeneration; to provide permanent repair of these acquired structural defects, one solution is to fabricate scaffolds that are designed to support the growth of annulus fibrosus cells. In this study, electrospun nanofibrous scaffolds of polycaprolactone are fabricated in random, aligned, and round-end configurations. Primary porcine annulus fibrosus cells are grown on the scaffolds and evaluated for attachment, proliferation, and production of extracellular matrix. The scaffold consisting of round-end nanofibers substantially outperforms the random and aligned scaffolds on cell adhesion; additionally, the scaffold with aligned nanofibers strongly affects the orientation of cells.

Authors+Show Affiliations

Biomedical Engineering Program, University of South Dakota, 4800 North Career Avenue, Sioux Falls, SD 57107, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21080441

Citation

Koepsell, Laura, et al. "Electrospun Nanofibrous Polycaprolactone Scaffolds for Tissue Engineering of Annulus Fibrosus." Macromolecular Bioscience, vol. 11, no. 3, 2011, pp. 391-9.
Koepsell L, Zhang L, Neufeld D, et al. Electrospun nanofibrous polycaprolactone scaffolds for tissue engineering of annulus fibrosus. Macromol Biosci. 2011;11(3):391-9.
Koepsell, L., Zhang, L., Neufeld, D., Fong, H., & Deng, Y. (2011). Electrospun nanofibrous polycaprolactone scaffolds for tissue engineering of annulus fibrosus. Macromolecular Bioscience, 11(3), pp. 391-9. doi:10.1002/mabi.201000352.
Koepsell L, et al. Electrospun Nanofibrous Polycaprolactone Scaffolds for Tissue Engineering of Annulus Fibrosus. Macromol Biosci. 2011 Mar 10;11(3):391-9. PubMed PMID: 21080441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrospun nanofibrous polycaprolactone scaffolds for tissue engineering of annulus fibrosus. AU - Koepsell,Laura, AU - Zhang,Lifeng, AU - Neufeld,Daniel, AU - Fong,Hao, AU - Deng,Ying, Y1 - 2010/11/15/ PY - 2010/08/30/received PY - 2010/09/24/revised PY - 2010/11/17/entrez PY - 2010/11/17/pubmed PY - 2011/6/17/medline SP - 391 EP - 9 JF - Macromolecular bioscience JO - Macromol Biosci VL - 11 IS - 3 N2 - The annulus fibrosus comprises concentric lamellae that can be damaged due to intervertebral disc degeneration; to provide permanent repair of these acquired structural defects, one solution is to fabricate scaffolds that are designed to support the growth of annulus fibrosus cells. In this study, electrospun nanofibrous scaffolds of polycaprolactone are fabricated in random, aligned, and round-end configurations. Primary porcine annulus fibrosus cells are grown on the scaffolds and evaluated for attachment, proliferation, and production of extracellular matrix. The scaffold consisting of round-end nanofibers substantially outperforms the random and aligned scaffolds on cell adhesion; additionally, the scaffold with aligned nanofibers strongly affects the orientation of cells. SN - 1616-5195 UR - https://www.unboundmedicine.com/medline/citation/21080441/Electrospun_nanofibrous_polycaprolactone_scaffolds_for_tissue_engineering_of_annulus_fibrosus_ L2 - https://doi.org/10.1002/mabi.201000352 DB - PRIME DP - Unbound Medicine ER -